Castleman's disease in the head of the pancreas: report of a rare clinical entity and current perspective on diagnosis, treatment, and outcome

World Journal of Surgical Oncology - Tập 5 - Trang 1-6 - 2007
Hongbei Wang1, Rosemary L Wieczorek2, Michael E Zenilman3, Fidelina Desoto-Lapaix2, Bimal C Ghosh4,3, Wilbur B Bowne4,3
1Department of Pathology, The State University of New York, Health Science Center of Brooklyn, USA
2Department of Pathology, Department of Veterans Affairs, New York Harbor Health Care System, Brooklyn, USA
3Department of Surgery, The State University of New York, Health Science Center of Brooklyn, Brooklyn, USA
4Department of Surgery, Department of Veterans Affairs, New York Harbor Health Care System, Brooklyn, USA

Tóm tắt

Castleman's disease of the pancreas is a very rare condition that may resemble more common disease entities as well as pancreatic cancer. Here we report the case of a 58-year-old African American male with an incidentally discovered lesion in the head of the pancreas. The specimen from his pancreaticoduodectomy contained a protuberant, encapsulated mass, exhibiting microscopic features most consistent with localized/unicentric Castleman's disease. These included florid follicular hyperplasia with mantle/marginal zone hyperplasia along with focal progressive transformation of germinal centers admixed with involuted germinal centers. To date, eight cases of Castleman's disease associated with the pancreas have been described in the world literature. We report the first case of unicentric disease situated within the head of the pancreas. In addition, we discuss the diagnostic dilemma Castleman's disease may present to the pancreatic surgeon and review current data on pathogenesis, treatment, and outcome.

Tài liệu tham khảo

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