AbstractA stereological method for obtaining estimates of the total number of
neurons in five major subdivisions of the rat hippocampus is described. The new
method, the optical fractionator, combines two recent developments in
stereology: a three‐dimensional probe for counting neuronal nuclei, the optical
disector, and a systematic uniform sampling scheme, the fractionator. The
optical disector r... hiện toàn bộ
AbstractThe observed fit of bone mass to a healthy animal's typical mechanical
usage indicates some mechanism or mechanisms monitor that usage and control the
three longitudinal growth, bone modeling, and BMU‐based remodeling activities
that directly determine bone mass. That mechanism could be named a mechanostat.
Accumulated evidence suggests it includes the bone itself, plus mechanisms that
tra... hiện toàn bộ
AbstractThe properties of the inorganic dye ruthenium red are presented with
emphasis upon its use for electron microscopy of cells and tissues. Although
commercial ruthenium red often can be used directly, it always contains various
impurities and by‐products. One of these, termed ruthenium violet, can be
isolated and is useful by itself. Absorption spectra of the ruthenium dyes and
common impuri... hiện toàn bộ
AbstractThe source of the new nuclei appearing during the growth of muscle
fibers was examined in the tibialis anterior muscle of young Sherman rats (14–17
days of age) using radioautography at various intervals after a single injection
of a small, non‐toxic dose of 3H‐thymidine (2 μCi/g body weight). Two techniques
were employed: (1) labeled nuclei were detected in 1 μ thick radioautographs
exami... hiện toàn bộ
AbstractIn normal adult rats some germ cells degenerate at several vulnerable
steps of spermatogenesis. These are the type A spermatogonia, midpachytene
spermatocytes, primary and secondary spermatocytes which degenerate during their
respective maturation divisions and step 7 and 19 spermatids. In the present
study, these degenerating cells were examined under the electron microscope, and
their fr... hiện toàn bộ
M. Ashraf Aziz, James C. McKenzie, James S. Wilson, Robert J. Cowie, Sylvanus A. Ayeni, Barbara K. Dunn
AbstractMajor national and international critiques of the medical curriculum in
the 1980s noted the following significant flaws: (1) over‐reliance on learning
by rote memory, (2) insufficient exercise in analysis and
synthesis/conceptualization, and (3) failure to connect the basic and clinical
aspects of training. It was argued that the invention of computers and related
imaging techniques called... hiện toàn bộ
AbstractA method for rapid freezing is described in which use is made of the
good heat conducting properties of silver. The freezing was accomplished by
bringing the tissue in contact with a polished silver surface at the temperature
of liquid nitrogen either at atmospheric or reduced pressure. Helium gas flowing
over this surface prevented the condensation of water or air on the silver.
After fre... hiện toàn bộ