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Solid phase peptide synthesis utilizing 9‐fluorenylmethoxycarbonyl amino acids9‐Fluorenylmethoxycarbonyl (Fmoc) amino acids were first used for solid phase peptide synthesis a little more than a decade ago. Since that time, Fmoc solid phase peptide synthesis methodology has been greatly enhanced by the introduction of a variety of solid supports, linkages, and side chain protecting groups, as well as by increased understanding of solvation conditions. These advances... ...
Tập 35 Số 3 - Trang 161-214 - 1990
SOLID‐PHASE PEPTIDE SYNTHESIS USING MILD BASE CLEAVAGE OF NαFLUORENYLMETHYLOXYCARBONYLAMINO ACIDS, EXEMPLIFIED BY A SYNTHESIS OF DIHYDROSOMATOSTATIN N
α ‐9‐Fluorenylmethyloxycarbonyl (Fmoc) amino acids will be of advantage in solid phase peptide synthesis. The Fmoc‐group is quantitatively cleaved by mild base (piperidine). This permits the use of tert‐butyl‐type side chain blocking and of peptide‐to‐resin linkage cleavable by mild acidolysis. Side reactions arising from repetiti... ...
Tập 11 Số 3 - Trang 246-249 - 1978
Isolation and characterization of two distinct lectins with antiproliferative activity from the cultured mycelium of the edible mushroom Tricholoma mongolicumTwo lectins, TML‐1 and TML‐2, were isolated from Tricholoma mongolicum by ion‐exchange chromatography and gel filtration. They are dimers with molecular weight near 37 000. The hemagglutinating activities of TML‐1 and TML‐2 are sensitive to lactose inhibition and are stable between 10 and 80 °C. They exhibit antiproliferative activities against mouse monocyte‐mac... ...
Tập 46 Số 6 - Trang 508-513 - 1995
The toxic peptides from Amanita mushroomsThe results of 50 years of effort in the chemistry of Amanita toxins are reviewed. The phallotoxins, fast acting components, but not responsible for fatal intoxications after ingestion, are bicyclic heptapeptides. They combine with F‐actin, stabilizing this protein against several destabilizing influences. The virotoxins likewise fast acting are monocyclic heptapeptides. The amatoxins whic... ...
Tập 22 Số 3 - Trang 257-276 - 1983
A common cytolytic region in myotoxins, hemolysins, cardiotoxins and antibacterial peptides*Several proteins and polypeptides of reptilian, amphibian, insect, and microbial origin share a common cytolytic property. However, these cytolysins fulfill different objectives. They provide offensive armament in the case of toxins, but defensive systems in the case of antibacterial peptides. The sequences of several nonenzymatic cytolysins and their analogues were compared to identify th... ...
Tập 34 Số 4 - Trang 277-286 - 1989
Amino acid structure and “difficult sequences” in solid phase peptide synthesisDeprotection peak profiles have been determined as a measure of internal aggregation during Fmoc‐polyamide continuous flow solid phase synthesis. The results have been correlated with amino‐acid structure and discussed in terms of minimising aggregation during synthesis.
Tập 40 Số 3-4 - Trang 300-307 - 1992
Stereochemistry of collagen*This review article, based on a lecture delivered in Madras in 1985, is an account of the author's experience in the working out of the molecular structure and conformation of the collagen triple‐helix over the years 1952–78. It starts with the first proposal of the correct triple‐helix in 1954, but with three residues per turn, which was later refined in 1955 into a coiled‐coil structure ... ...
Tập 31 Số 1 - Trang 1-16 - 1988
Use of N,O‐bis‐Fmoc‐d ‐Tyr‐ONSu for introduction of an oxidative iodination site into cholecystokinin family peptidesWe report the synthesis of a new reagent for the introduction of an oxidative iodination site into the amino terminus of acid‐labile peptides, and the use of this reagent to synthesize a novel affinity‐labeling probe for the cholecystokinin (CCK) receptor. The acylation reagent, N,O ‐bis‐fluorenylmethyloxycarbonyl‐d ‐tyrosine hydroxysuccinimide e... ...
Tập 31 Số 5 - Trang 429-434 - 1988
Conformational modifications of cyclic hexapeptide somatostatin analogsA model for the bioactive conformation of the highly active cyclic hexapeptide somatostatin analog cyclo‐(Pro‐Phe‐d ‐Trp‐Lys‐Thr‐Phe) has been proposed. As a test of this model, several compounds containing lactam and N ‐Me amino acid conformational modifications in the Thr‐Phe‐Pro‐Phe beta turn were synthesized. The N ‐... ...
Tập 23 Số 2 - Trang 142-150 - 1984
Isolation of a heptapeptide Val‐Val‐Tyr‐Pro‐Trp‐Thr‐Gln (valorphin) with some opiate activityBovine hypothalamic tissue was extracted and purified by solid phase extraction and several reversed‐phase HPLC steps. The amino acid sequence of the purified peptide was determined by Edman degradation to be Val‐Val‐Tyr‐Pro‐Trp‐Thr‐Gln. This was confirmed by comparison of its chromatographic behavior with that of the synthetic peptide, and mass spectrometric analysis resulted in a mass id... ...
Tập 39 Số 6 - Trang 477-484 - 1992