Wiley
SCOPUS (1972-1996,2017)
0367-8377
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Solid phase peptide synthesis utilizing 9‐fluorenylmethoxycarbonyl amino acids
Tập 35 Số 3 - Trang 161-214 - 1990
9‐Fluorenylmethoxycarbonyl (Fmoc) amino acids were first used for solid phase
peptide synthesis a little more than a decade ago. Since that time, Fmoc solid
phase peptide synthesis methodology has been greatly enhanced by the
introduction of a variety of solid supports, linkages, and side chain protecting
groups, as well as by increased understanding of solvation conditions. These
advances have le...
SOLID‐PHASE PEPTIDE SYNTHESIS USING MILD BASE CLEAVAGE OF NαFLUORENYLMETHYLOXYCARBONYLAMINO ACIDS, EXEMPLIFIED BY A SYNTHESIS OF DIHYDROSOMATOSTATIN
Tập 11 Số 3 - Trang 246-249 - 1978
N α‐9‐Fluorenylmethyloxycarbonyl (Fmoc) amino acids will be of advantage in
solid phase peptide synthesis. The Fmoc‐group is quantitatively cleaved by mild
base (piperidine). This permits the use of tert‐butyl‐type side chain blocking
and of peptide‐to‐resin linkage cleavable by mild acidolysis. Side reactions
arising from repetitive acid deprotection and final HF cleavage in contemporary
solid ph...
Isolation and characterization of two distinct lectins with antiproliferative activity from the cultured mycelium of the edible mushroom Tricholoma mongolicum
Tập 46 Số 6 - Trang 508-513 - 1995
Two lectins, TML‐1 and TML‐2, were isolated from Tricholoma mongolicum by
ion‐exchange chromatography and gel filtration. They are dimers with molecular
weight near 37 000. The hemagglutinating activities of TML‐1 and TML‐2 are
sensitive to lactose inhibition and are stable between 10 and 80 °C. They
exhibit antiproliferative activities against mouse monocyte‐macrophage PU5–1.8
cells and mouse mas...
The toxic peptides from Amanita mushrooms
Tập 22 Số 3 - Trang 257-276 - 1983
The results of 50 years of effort in the chemistry of Amanita toxins are
reviewed. The phallotoxins, fast acting components, but not responsible for
fatal intoxications after ingestion, are bicyclic heptapeptides. They combine
with F‐actin, stabilizing this protein against several destabilizing influences.
The virotoxins likewise fast acting are monocyclic heptapeptides. The amatoxins
which are th...
A common cytolytic region in myotoxins, hemolysins, cardiotoxins and antibacterial peptides*
Tập 34 Số 4 - Trang 277-286 - 1989
Several proteins and polypeptides of reptilian, amphibian, insect, and microbial
origin share a common cytolytic property. However, these cytolysins fulfill
different objectives. They provide offensive armament in the case of toxins, but
defensive systems in the case of antibacterial peptides. The sequences of
several nonenzymatic cytolysins and their analogues were compared to identify
the struct...
Amino acid structure and “difficult sequences” in solid phase peptide synthesis
Tập 40 Số 3-4 - Trang 300-307 - 1992
Deprotection peak profiles have been determined as a measure of internal
aggregation during Fmoc‐polyamide continuous flow solid phase synthesis. The
results have been correlated with amino‐acid structure and discussed in terms of
minimising aggregation during synthesis.
Stereochemistry of collagen*
Tập 31 Số 1 - Trang 1-16 - 1988
This review article, based on a lecture delivered in Madras in 1985, is an
account of the author's experience in the working out of the molecular structure
and conformation of the collagen triple‐helix over the years 1952–78. It starts
with the first proposal of the correct triple‐helix in 1954, but with three
residues per turn, which was later refined in 1955 into a coiled‐coil structure
with app...
Use of N,O‐bis‐Fmoc‐d ‐Tyr‐ONSu for introduction of an oxidative iodination site into cholecystokinin family peptides
Tập 31 Số 5 - Trang 429-434 - 1988
We report the synthesis of a new reagent for the introduction of an oxidative
iodination site into the amino terminus of acid‐labile peptides, and the use of
this reagent to synthesize a novel affinity‐labeling probe for the
cholecystokinin (CCK) receptor. The acylation reagent,
N,O‐bis‐fluorenylmethyloxycarbonyl‐d‐tyrosine hydroxysuccinimide ester, utilizes
base‐labile protection of both the alph...
Conformational modifications of cyclic hexapeptide somatostatin analogs
Tập 23 Số 2 - Trang 142-150 - 1984
A model for the bioactive conformation of the highly active cyclic hexapeptide
somatostatin analog cyclo‐(Pro‐Phe‐d‐Trp‐Lys‐Thr‐Phe) has been proposed. As a
test of this model, several compounds containing lactam and N‐Me amino acid
conformational modifications in the Thr‐Phe‐Pro‐Phe beta turn were synthesized.
The N‐Me alanine and sarcosine substitutions for proline gave highly active
analogs, wh...
Isolation of a heptapeptide Val‐Val‐Tyr‐Pro‐Trp‐Thr‐Gln (valorphin) with some opiate activity
Tập 39 Số 6 - Trang 477-484 - 1992
Bovine hypothalamic tissue was extracted and purified by solid phase extraction
and several reversed‐phase HPLC steps. The amino acid sequence of the purified
peptide was determined by Edman degradation to be Val‐Val‐Tyr‐Pro‐Trp‐Thr‐Gln.
This was confirmed by comparison of its chromatographic behavior with that of
the synthetic peptide, and mass spectrometric analysis resulted in a mass
identical ...