Amino acid structure and “difficult sequences” in solid phase peptide synthesis

Wiley - Tập 40 Số 3-4 - Trang 300-307 - 1992
J Bedford1, Carolyn B. Hyde, Tony Johnson, Jun Wang, David Owen, Martin Quibell, R. C. Sheppard
1MRC Laboratory of Molecular Biology, Cambridge, UK

Tóm tắt

Deprotection peak profiles have been determined as a measure of internal aggregation during Fmoc‐polyamide continuous flow solid phase synthesis. The results have been correlated with amino‐acid structure and discussed in terms of minimising aggregation during synthesis.

Từ khóa


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