Wiley
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
2‐Phenylethyl ester and 2‐phenylethyl amide derivative analogues of the C‐terminal hepta‐ and octapeptide of cholecystokininSyntheses of analogues of the C ‐terminal octa‐ and heptapeptide of cholecystokinin are described. These analogues were obtained by replacing the C ‐terminal phenylalanine residue by 2‐phenylethyl alcohol or by 2‐phenylethylamine derivatives and by replacing the tryptophan residue by a d ‐tryptophan. The CCK‐derivatives ... ...
Wiley - Tập 32 Số 5 - Trang 384-395 - 1988
Phenylethylamide derivatives of the C‐terminal tetrapeptide of gastrinPeptide analogues of the C‐terminal tetrapeptide of gastrin in which the phenyl‐alanine had been replaced were synthesized and their biological activity on acid secretion evaluated. Compounds Boc‐Trp‐Leu‐Asp phenylethylamide 6 , Boc‐β‐Ala‐Trp‐Leu‐Asp phenylethylamide 9 , Boc‐Trp‐Leu‐Asp p‐fluorophenylethylamide 19...
Wiley - Tập 28 Số 5 - Trang 529-535 - 1986
Structure‐conformation relationships of synthetic peptide inhibitors of human renin studied by resonance energy transfer and molecular modelingThe structure‐conformation relationships of a series of angiotensinogen6–13 (ANG6–13 , His‐Pro‐Phe‐His‐Leu‐Val‐Ile‐His) congeners substituted by N in ‐For‐Trp (Ftr), d ‐Ftr or Trp at the N ‐terminus, Tyr at the C ‐terminus and PheΨ[CH<... ...
Wiley - Tập 31 Số 1 - Trang 22-34 - 1988
Stereochemistry of collagen*This review article, based on a lecture delivered in Madras in 1985, is an account of the author's experience in the working out of the molecular structure and conformation of the collagen triple‐helix over the years 1952–78. It starts with the first proposal of the correct triple‐helix in 1954, but with three residues per turn, which was later refined in 1955 into a coiled‐coil structure ... ...
Wiley - Tập 31 Số 1 - Trang 1-16 - 1988
ANALOGS OF AMANINIie3 ‐amaninamide (3‐R) and its diastereomeric sulfoxide (3‐S) are obtained by oxidation of the bicyclic thioether peptide 2 by hydrogen peroxide in acetic acid. 2 was prepared by an intramolecular Savige‐Fontana reaction of the linear octapeptide tert.‐butylester 4 whose N ‐terminal Boc‐Hpi residue on treatment with TFA loses the Boc group and... ...
Wiley - Tập 18 Số 2 - Trang 162-168 - 1981
The toxic peptides from Amanita mushroomsThe results of 50 years of effort in the chemistry of Amanita toxins are reviewed. The phallotoxins, fast acting components, but not responsible for fatal intoxications after ingestion, are bicyclic heptapeptides. They combine with F‐actin, stabilizing this protein against several destabilizing influences. The virotoxins likewise fast acting are monocyclic heptapeptides. The amatoxins whic... ...
Wiley - Tập 22 Số 3 - Trang 257-276 - 1983
PURIFICATION AND HETEROGENEITY OF HUMAN KININOGEN.Various methods of preparing human kininogen were investigated with an aim to limit the immunoreactive contaminant proteins to permit purification by immunosorption. A five‐step procedure is described giving 7.5% yield of highly purified kininogen (pharmacological purity 14–20) from pooled human plasma, and containing approximately 30% alpha‐2HS‐glycoprotein and 2.8% albumin. Alpha‐2HS cou... ...
Wiley - Tập 7 Số 3 - Trang 261-280 - 1975
SYNTHESIS OF PEPTIDES BY FRAGMENT CONDENSATION ON A SOLID SUPPORT.Two tripeptides and one dipeptide, protected except at the carboxyl ends, have been prepared in solution and used as intermediates in a new synthesis of bradykinin on a solid support. Condensation of the two tripeptides to the resin was effected in satisfactory yield with dicyclohexylcarbodiimide plus N ‐hydroxysuccinimide. The partial epimerization that might occ... ...
Wiley - Tập 7 Số 4 - Trang 307-312 - 1975
Synthesis of neuropeptide Y*Neuropeptide Y (NPY), a hexatriacontapeptide amide, was synthesized on benzhydrylamine resin. The peptide product obtained by HF treatment contained 63% of the target peptide, NPY. A comparison of the chemical, immuno‐chemical and biological properties of the synthetic peptide with natural NPY indicated that they were identical.
Wiley - Tập 29 Số 1 - Trang 78-83 - 1987
Isolation of a heptapeptide Val‐Val‐Tyr‐Pro‐Trp‐Thr‐Gln (valorphin) with some opiate activityBovine hypothalamic tissue was extracted and purified by solid phase extraction and several reversed‐phase HPLC steps. The amino acid sequence of the purified peptide was determined by Edman degradation to be Val‐Val‐Tyr‐Pro‐Trp‐Thr‐Gln. This was confirmed by comparison of its chromatographic behavior with that of the synthetic peptide, and mass spectrometric analysis resulted in a mass id... ...
Wiley - Tập 39 Số 6 - Trang 477-484 - 1992
Tổng số: 34
- 1
- 2
- 3
- 4