Wiley
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2‐Phenylethyl ester and 2‐phenylethyl amide derivative analogues of the C‐terminal hepta‐ and octapeptide of cholecystokinin
Wiley - Tập 32 Số 5 - Trang 384-395 - 1988
Syntheses of analogues of the C‐terminal octa‐ and heptapeptide of
cholecystokinin are described. These analogues were obtained by replacing the
C‐terminal phenylalanine residue by 2‐phenylethyl alcohol or by
2‐phenylethylamine derivatives and by replacing the tryptophan residue by a
d‐tryptophan. The CCK‐derivatives were tested for their ability to inhibit
binding of labeled CCK‐8 to rat pancreat...
Phenylethylamide derivatives of the C‐terminal tetrapeptide of gastrin
Wiley - Tập 28 Số 5 - Trang 529-535 - 1986
Peptide analogues of the C‐terminal tetrapeptide of gastrin in which the
phenyl‐alanine had been replaced were synthesized and their biological activity
on acid secretion evaluated. Compounds Boc‐Trp‐Leu‐Asp phenylethylamide 6,
Boc‐β‐Ala‐Trp‐Leu‐Asp phenylethylamide 9, Boc‐Trp‐Leu‐Asp
p‐fluorophenylethylamide 19, Boc‐Trp‐ø(CH2NH)‐Leu‐Asp phenylethylamide 23,
Boc‐Trp‐Leu‐Asp 2,2‐diphenylethylamide ...
Structure‐conformation relationships of synthetic peptide inhibitors of human renin studied by resonance energy transfer and molecular modeling
Wiley - Tập 31 Số 1 - Trang 22-34 - 1988
The structure‐conformation relationships of a series of angiotensinogen6–13
(ANG6–13, His‐Pro‐Phe‐His‐Leu‐Val‐Ile‐His) congeners substituted by Nin‐For‐Trp
(Ftr), d‐Ftr or Trp at the N‐terminus, Tyr at the C‐terminus and PheΨ[CH2NH]Phe
at the P1‐P′1 cleavage site (i.e. Leu10‐Val11) were studied using resonance
energy transfer coupled with molecular modeling of the peptide conformation
using macrom...
Stereochemistry of collagen*
Wiley - Tập 31 Số 1 - Trang 1-16 - 1988
This review article, based on a lecture delivered in Madras in 1985, is an
account of the author's experience in the working out of the molecular structure
and conformation of the collagen triple‐helix over the years 1952–78. It starts
with the first proposal of the correct triple‐helix in 1954, but with three
residues per turn, which was later refined in 1955 into a coiled‐coil structure
with app...
The toxic peptides from Amanita mushrooms
Wiley - Tập 22 Số 3 - Trang 257-276 - 1983
The results of 50 years of effort in the chemistry of Amanita toxins are
reviewed. The phallotoxins, fast acting components, but not responsible for
fatal intoxications after ingestion, are bicyclic heptapeptides. They combine
with F‐actin, stabilizing this protein against several destabilizing influences.
The virotoxins likewise fast acting are monocyclic heptapeptides. The amatoxins
which are th...
ANALOGS OF AMANIN
Wiley - Tập 18 Số 2 - Trang 162-168 - 1981
Iie3‐amaninamide (3‐R) and its diastereomeric sulfoxide (3‐S) are obtained by
oxidation of the bicyclic thioether peptide 2 by hydrogen peroxide in acetic
acid. 2 was prepared by an intramolecular Savige‐Fontana reaction of the linear
octapeptide tert.‐butylester 4 whose N‐terminal Boc‐Hpi residue on treatment
with TFA loses the Boc group and reacts under thioether formation with the
released cyst...
PURIFICATION AND HETEROGENEITY OF HUMAN KININOGEN.
Wiley - Tập 7 Số 3 - Trang 261-280 - 1975
Various methods of preparing human kininogen were investigated with an aim to
limit the immunoreactive contaminant proteins to permit purification by
immunosorption. A five‐step procedure is described giving 7.5% yield of highly
purified kininogen (pharmacological purity 14–20) from pooled human plasma, and
containing approximately 30% alpha‐2HS‐glycoprotein and 2.8% albumin. Alpha‐2HS
could not b...
SYNTHESIS OF PEPTIDES BY FRAGMENT CONDENSATION ON A SOLID SUPPORT.
Wiley - Tập 7 Số 4 - Trang 307-312 - 1975
Two tripeptides and one dipeptide, protected except at the carboxyl ends, have
been prepared in solution and used as intermediates in a new synthesis of
bradykinin on a solid support. Condensation of the two tripeptides to the resin
was effected in satisfactory yield with dicyclohexylcarbodiimide plus
N‐hydroxysuccinimide. The partial epimerization that might occur by such an
approach was explicit...
Synthesis of neuropeptide Y*
Wiley - Tập 29 Số 1 - Trang 78-83 - 1987
Neuropeptide Y (NPY), a hexatriacontapeptide amide, was synthesized on
benzhydrylamine resin. The peptide product obtained by HF treatment contained
63% of the target peptide, NPY. A comparison of the chemical, immuno‐chemical
and biological properties of the synthetic peptide with natural NPY indicated
that they were identical.
Isolation of a heptapeptide Val‐Val‐Tyr‐Pro‐Trp‐Thr‐Gln (valorphin) with some opiate activity
Wiley - Tập 39 Số 6 - Trang 477-484 - 1992
Bovine hypothalamic tissue was extracted and purified by solid phase extraction
and several reversed‐phase HPLC steps. The amino acid sequence of the purified
peptide was determined by Edman degradation to be Val‐Val‐Tyr‐Pro‐Trp‐Thr‐Gln.
This was confirmed by comparison of its chromatographic behavior with that of
the synthetic peptide, and mass spectrometric analysis resulted in a mass
identical ...
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