Wiley
0192-2521
1930-238X
Cơ quản chủ quản: N/A
Các bài báo tiêu biểu
Somatic mutation and recombination test in Drosophila melanogaster
Tập 6 Số 2 - Trang 153-188 - 1984
AbstractA novel test system for the detection of mutagenic and recombinogenic
activity of chemicals is described in detail. Drosophila melanogaster larvae
trans‐heterozygous for the mutations multiple wing hairs (mwh) and flare (fir)
are exposed to the test compounds for various periods of time ranging from 96 hr
to 1 hr. Induced mutations are detected as single mosaic spots on the wing blade
of s...
Ap endonucleases and dna glycosylases that recognize oxidative dna damage
Tập 12 Số 4 - Trang 431-477 - 1988
Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3‐butadiene
Tập 9 Số 3 - Trang 235-250 - 1987
AbstractGroups of male B6C3F1 mice (N = 12) were exposed to ambient air or to
gaseous 1,3‐butadiene (BD) at 6.25, 62.5, and 625 ppm for 10 exposure days (6 hr
+ T90/day). Exposure to BD induced in bone marrow: 1) a significant increase in
the frequency of chromosomal aberrations (CA); 2) a significant elevation in the
frequency of sister chromatid exchanges (SCE); 3) a significant lengthening of
t...
Ethylene oxide: Evidence of human chromosomal effects
Tập 1 Số 4 - Trang 375-382 - 1979
AbstractEthylene oxide is a known mutagen as indicated by short‐term testing in
vitro and in vivo. Occupational exposure can occur during ethylene oxide gas
sterilization of materials for hospital and other use. To study the problem in a
hospital sterilization facility where occupational exposure was suspected,
epidemiologic, analytic, and bioassay tools were employed. All persons whose
work activ...
Variation in the baseline sister chromatid exchange frequency in human lymphocytes
Tập 2 Số 3 - Trang 325-337 - 1980
AbstractThe utility of the sister chromatid exchange (SCE) assay for human
population studies is potentially limited by the variability associated with
individual baseline SCE frequencies. This investigation identifies and
quantifies the major sources of preparative and biological variation associated
with the determination of baseline SCE frequencies in cultured human
lymphocytes. Much of the var...
The genetic toxicology of metal compounds: I. Induction of λ prophage in E coli WP2S(λ)
Tập 6 Số 1 - Trang 59-69 - 1984
AbstractA number of metal compounds have been shown to be human carcinogens.
Others, while not proven human carcinogens, are able to cause tumors in
laboratory animals. Short‐term bacterial assays for genotoxic effects have not
been successful in predicting the carcinogenicity of metal compounds. We report
here the ability of some metal compounds to cause the induction of λ prophage in
E coli WP2S...
Sister chromatid exchange and chromosome aberration analyses in mice after in vivo exposure to acrylonitrile, styrene, or butadiene monoxide
Tập 8 Số 3 - Trang 439-448 - 1986
AbstractThe use of polymers in plastic and rubber products has generated concern
that monomers potentially active in biological systems may be eluted from these
substances. We have evaluated two such monomers, acrylonitrile and styrene, for
the induction of chromosome damage in mice. Butadiene monoxide, a presumed
metabolite of a third important monomer, 1,3‐butadiene, was also tested. These
chemi...
Pesticide‐induced complete and partial chromosome loss in screens with repair‐defective females of drosophila melanogaster
Tập 5 Số 6 - Trang 835-846 - 1983
AbstractCommercial preparation of fungicides (captan and maneb), herbicides
(bromacil, paraquat, picloram, and 2,4‐D), and insecticides (carbaryl,
chlorpyrifos, dimethoate, DDT, diazinon, carbofuran, and permethrin) were tested
for their ability to induce complete and partial chromosome losses in Drosophila
melanogaster males. In an attempt to identify the mutagenic activity of
pesticides that are...
Chromosome aberrations and sister chromatid exchanges in styrene‐exposed workers with reference to their smoking habits
Tập 5 Số 3 - Trang 299-309 - 1983
AbstractThe incidences of chromosome aberrations and the frequencies of sister
chromatid exchanges (SCE) were investigated in cultured lymphocytes of 18
styrene‐exposed workers in comparison with six controls. There was a marginal
increase in the incidence of structural chromosomal aberrations in
first‐division metaphases in the styrene‐exposed workers, as compared with the
nonexposed controls. Ho...