Wiley
0192-2521
1930-238X
Cơ quản chủ quản: N/A
Lĩnh vực:
Các bài báo tiêu biểu
Somatic mutation and recombination test in Drosophila melanogasterAbstract A novel test system for the detection of mutagenic and recombinogenic activity of chemicals is described in detail. Drosophila melanogaster larvae trans‐heterozygous for the mutations multiple wing hairs (mwh) and flare (fir) are exposed to the test compounds for various periods of time ranging from 96 hr to 1 hr. Induced mutation... ...
Tập 6 Số 2 - Trang 153-188 - 1984
Ap endonucleases and dna glycosylases that recognize oxidative dna damage
Tập 12 Số 4 - Trang 431-477 - 1988
Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3‐butadieneAbstract Groups of male B6C3F1 mice (N = 12) were exposed to ambient air or to gaseous 1,3‐butadiene (BD) at 6.25, 62.5, and 625 ppm for 10 exposure days (6 hr + T90 /day). Exposure to BD induced in bone marrow: 1) a significant increase in the frequency of chromosomal aberrations (CA); 2) a significant elevation in the frequency of sister chroma... ...
Tập 9 Số 3 - Trang 235-250 - 1987
Ethylene oxide: Evidence of human chromosomal effectsAbstract Ethylene oxide is a known mutagen as indicated by short‐term testing in vitro and in vivo. Occupational exposure can occur during ethylene oxide gas sterilization of materials for hospital and other use. To study the problem in a hospital sterilization facility where occupational exposure was suspected, epidemiologic, analytic, and bioassay tools were emplo... ...
Tập 1 Số 4 - Trang 375-382 - 1979
Variation in the baseline sister chromatid exchange frequency in human lymphocytesAbstract The utility of the sister chromatid exchange (SCE) assay for human population studies is potentially limited by the variability associated with individual baseline SCE frequencies. This investigation identifies and quantifies the major sources of preparative and biological variation associated with the determination of baseline SCE frequencies in cultured h... ...
Tập 2 Số 3 - Trang 325-337 - 1980
The genetic toxicology of metal compounds: I. Induction of λ prophage in E coli WP2S(λ)Abstract A number of metal compounds have been shown to be human carcinogens. Others, while not proven human carcinogens, are able to cause tumors in laboratory animals. Short‐term bacterial assays for genotoxic effects have not been successful in predicting the carcinogenicity of metal compounds. We report here the ability of some metal compounds to cause the induc... ...
Tập 6 Số 1 - Trang 59-69 - 1984
Sister chromatid exchange and chromosome aberration analyses in mice after in vivo exposure to acrylonitrile, styrene, or butadiene monoxideAbstract The use of polymers in plastic and rubber products has generated concern that monomers potentially active in biological systems may be eluted from these substances. We have evaluated two such monomers, acrylonitrile and styrene, for the induction of chromosome damage in mice. Butadiene monoxide, a presumed metabolite of a third important monomer, 1,3‐butadi... ...
Tập 8 Số 3 - Trang 439-448 - 1986
Pesticide‐induced complete and partial chromosome loss in screens with repair‐defective females of drosophila melanogasterAbstract Commercial preparation of fungicides (captan and maneb), herbicides (bromacil, paraquat, picloram, and 2,4‐D), and insecticides (carbaryl, chlorpyrifos, dimethoate, DDT, diazinon, carbofuran, and permethrin) were tested for their ability to induce complete and partial chromosome losses in Drosophila melanogaster males. In an attempt to identify the mutageni... ...
Tập 5 Số 6 - Trang 835-846 - 1983
Chromosome aberrations and sister chromatid exchanges in styrene‐exposed workers with reference to their smoking habitsAbstract The incidences of chromosome aberrations and the frequencies of sister chromatid exchanges (SCE) were investigated in cultured lymphocytes of 18 styrene‐exposed workers in comparison with six controls. There was a marginal increase in the incidence of structural chromosomal aberrations in first‐division metaphases in the styrene‐exposed workers, as compared... ...
Tập 5 Số 3 - Trang 299-309 - 1983