Wiley
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Sister chromatid exchange and chromosome aberration analyses in mice after in vivo exposure to acrylonitrile, styrene, or butadiene monoxideAbstract The use of polymers in plastic and rubber products has generated concern that monomers potentially active in biological systems may be eluted from these substances. We have evaluated two such monomers, acrylonitrile and styrene, for the induction of chromosome damage in mice. Butadiene monoxide, a presumed metabolite of a third important monomer, 1,3‐butadi... ... hiện toàn bộ
Wiley - Tập 8 Số 3 - Trang 439-448 - 1986
Chromosome aberrations and sister chromatid exchanges in styrene‐exposed workers with reference to their smoking habitsAbstract The incidences of chromosome aberrations and the frequencies of sister chromatid exchanges (SCE) were investigated in cultured lymphocytes of 18 styrene‐exposed workers in comparison with six controls. There was a marginal increase in the incidence of structural chromosomal aberrations in first‐division metaphases in the styrene‐exposed workers, as compared... ... hiện toàn bộ
Wiley - Tập 5 Số 3 - Trang 299-309 - 1983
Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3‐butadieneAbstract Groups of male B6C3F1 mice (N = 12) were exposed to ambient air or to gaseous 1,3‐butadiene (BD) at 6.25, 62.5, and 625 ppm for 10 exposure days (6 hr + T90 /day). Exposure to BD induced in bone marrow: 1) a significant increase in the frequency of chromosomal aberrations (CA); 2) a significant elevation in the frequency of sister chroma... ... hiện toàn bộ
Wiley - Tập 9 Số 3 - Trang 235-250 - 1987
The genetic toxicology of metal compounds: I. Induction of λ prophage in E coli WP2S(λ)Abstract A number of metal compounds have been shown to be human carcinogens. Others, while not proven human carcinogens, are able to cause tumors in laboratory animals. Short‐term bacterial assays for genotoxic effects have not been successful in predicting the carcinogenicity of metal compounds. We report here the ability of some metal compounds to cause the induc... ... hiện toàn bộ
Wiley - Tập 6 Số 1 - Trang 59-69 - 1984
Variation in the baseline sister chromatid exchange frequency in human lymphocytesAbstract The utility of the sister chromatid exchange (SCE) assay for human population studies is potentially limited by the variability associated with individual baseline SCE frequencies. This investigation identifies and quantifies the major sources of preparative and biological variation associated with the determination of baseline SCE frequencies in cultured h... ... hiện toàn bộ
Wiley - Tập 2 Số 3 - Trang 325-337 - 1980
Ethylene oxide: Evidence of human chromosomal effectsAbstract Ethylene oxide is a known mutagen as indicated by short‐term testing in vitro and in vivo. Occupational exposure can occur during ethylene oxide gas sterilization of materials for hospital and other use. To study the problem in a hospital sterilization facility where occupational exposure was suspected, epidemiologic, analytic, and bioassay tools were emplo... ... hiện toàn bộ
Wiley - Tập 1 Số 4 - Trang 375-382 - 1979
Sister chromatid exchanges induced in rabbit lymphocytes by ethylene oxide after inhalation exposureAbstract Ethylene oxide, which is the simplest epoxide and an extremely important commercial compound, has been used by many investigators as a model compound to study mutagenicity by alkylation of DNA. Knowledge of in vivo dose‐effect relations under experimental conditions may provide further insight into the dynamics of the sister chromatid exchange (SCE) respons... ... hiện toàn bộ
Wiley - Tập 4 Số 2 - Trang 121-134 - 1982
Sister chromatid exchanges in chines hamster cells treated with seventeen organophosphorus compounds in the presence of a metabolic activation systemAbstract The mutagenicity of several organophosphorus pesticides (OPP) has been demonstrated by Wild [1975] in microorganisms. However, the results as reported in the literature of cytogenic, mutagenic, and carcinogenic tests using mammalian cells or experimental animals were scanty and inconclusive [Huang, 1973; Wild, 1975]. This may be partly due to the high toxic... ... hiện toàn bộ
Wiley - Tập 4 Số 5 - Trang 621-624 - 1982
Somatic mutation and recombination test in Drosophila melanogasterAbstract A novel test system for the detection of mutagenic and recombinogenic activity of chemicals is described in detail. Drosophila melanogaster larvae trans‐heterozygous for the mutations multiple wing hairs (mwh) and flare (fir) are exposed to the test compounds for various periods of time ranging from 96 hr to 1 hr. Induced mutation... ... hiện toàn bộ
Wiley - Tập 6 Số 2 - Trang 153-188 - 1984
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