Wiley

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Ap endonucleases and dna glycosylases that recognize oxidative dna damage
Wiley - Tập 12 Số 4 - Trang 431-477 - 1988
Susan S. Wallace
Salmonella mutagenicity test results for 250 chemicals
Wiley - Tập 5 Số S1 - Trang 3-49 - 1983
Steve Haworth, Timothy E. Lawlor, Kristien Mortelmans, William T. Speck, Errol Zeiger
Somatic mutation and recombination test in Drosophila melanogaster
Wiley - Tập 6 Số 2 - Trang 153-188 - 1984
Ulrich Gräf, F.E. Würgler, Alan J. Katz, H. Frei, H. Juon, Caroline B. Hall, P.G. Kale
AbstractA novel test system for the detection of mutagenic and recombinogenic activity of chemicals is described in detail. Drosophila melanogaster larvae trans‐heterozygous for the mutations multiple wing hairs (mwh) and flare (fir) are exposed to the test compounds for various periods of time ranging from 96 hr to 1 hr. Induced mutation...... hiện toàn bộ
Sister chromatid exchanges in chines hamster cells treated with seventeen organophosphorus compounds in the presence of a metabolic activation system
Wiley - Tập 4 Số 5 - Trang 621-624 - 1982
H. H. Chen, S.R. Sirianni, C. C. Huang
AbstractThe mutagenicity of several organophosphorus pesticides (OPP) has been demonstrated by Wild [1975] in microorganisms. However, the results as reported in the literature of cytogenic, mutagenic, and carcinogenic tests using mammalian cells or experimental animals were scanty and inconclusive [Huang, 1973; Wild, 1975]. This may be partly due to the high toxic...... hiện toàn bộ
Pesticide‐induced complete and partial chromosome loss in screens with repair‐defective females of drosophila melanogaster
Wiley - Tập 5 Số 6 - Trang 835-846 - 1983
R. C. Woodruff, J. P. Phillips, David M. Irwin
AbstractCommercial preparation of fungicides (captan and maneb), herbicides (bromacil, paraquat, picloram, and 2,4‐D), and insecticides (carbaryl, chlorpyrifos, dimethoate, DDT, diazinon, carbofuran, and permethrin) were tested for their ability to induce complete and partial chromosome losses in Drosophila melanogaster males. In an attempt to identify the mutageni...... hiện toàn bộ
Sister chromatid exchange and chromosome aberration analyses in mice after in vivo exposure to acrylonitrile, styrene, or butadiene monoxide
Wiley - Tập 8 Số 3 - Trang 439-448 - 1986
Yousuf Sharief, Arthur Brown, Lorraine C. Backer, James A. Campbell, Barbara Westbrook‐Collins, Andrew G. Stead, James W. Allen
AbstractThe use of polymers in plastic and rubber products has generated concern that monomers potentially active in biological systems may be eluted from these substances. We have evaluated two such monomers, acrylonitrile and styrene, for the induction of chromosome damage in mice. Butadiene monoxide, a presumed metabolite of a third important monomer, 1,3‐butadi...... hiện toàn bộ
Chromosome aberrations and sister chromatid exchanges in styrene‐exposed workers with reference to their smoking habits
Wiley - Tập 5 Số 3 - Trang 299-309 - 1983
Toshiaki Watanabe, Akira Endo, Miho Kumai, Masayuki Ikeda
AbstractThe incidences of chromosome aberrations and the frequencies of sister chromatid exchanges (SCE) were investigated in cultured lymphocytes of 18 styrene‐exposed workers in comparison with six controls. There was a marginal increase in the incidence of structural chromosomal aberrations in first‐division metaphases in the styrene‐exposed workers, as compared...... hiện toàn bộ
Glutathione: A protective agent in Salmonella typhimurium and Escherichia coli as measured by mutagenicity and by growth delay assays
Wiley - Tập 8 Số 5 - Trang 659-673 - 1986
R. A. Owens, Philip Hartman
AbstractCultures of some aerobically grown strains of Salmonella typhimurium and Escherichia coli contain up to 24 μM extracellular glutathione (GSH) [Owens RO, Hartman PE (1985): Environ Mutagen 7(Suppl 3): 47] in addition to having intracellular GSH concentrations in the millimolar range. The addition of 26 μM...... hiện toàn bộ
Effect of bacterial concentration on reversions induced in salmonella typhimurium TA1538 by N‐hydroxy‐2‐acetylaminofluorene
Wiley - Tập 5 Số 4 - Trang 565-575 - 1983
G. L. White, David T. Beranek, Robert H. Heflich
AbstractReversions induced by N‐hydroxy‐2‐acetylaminofluorene (N‐OH‐AAF) were measured in the Salmonella/microsome quantitative plate assay using various concentrations of Salmonella typhimurium strain TA 1538. The number of induced revertants increased with an increasing number of bacteria/plate, but the variation in reversion frequency ...... hiện toàn bộ
The effect of culture conditions and toxicity on the ames salmonella/microsome agar incorporation mutagenicity assay
Wiley - Tập 5 Số 4 - Trang 541-551 - 1983
Sonja Kazmer, Morris Katz, David S. Weinstein
AbstractVarious methods were used to reconstruct an environment similar to a chemically bactericidal or bacteriostatic effect in the Ames mutagenicity assay in order to determine whether a false‐positive result could occur. Neither population reduction, sonication, nor increased histidine produced an increase of spurious revertant colonies.
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