Wiley
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Ap endonucleases and dna glycosylases that recognize oxidative dna damage
Wiley - Tập 12 Số 4 - Trang 431-477 - 1988
Sister chromatid exchanges in chines hamster cells treated with seventeen organophosphorus compounds in the presence of a metabolic activation system
Wiley - Tập 4 Số 5 - Trang 621-624 - 1982
AbstractThe mutagenicity of several organophosphorus pesticides (OPP) has been
demonstrated by Wild [1975] in microorganisms. However, the results as reported
in the literature of cytogenic, mutagenic, and carcinogenic tests using
mammalian cells or experimental animals were scanty and inconclusive [Huang,
1973; Wild, 1975]. This may be partly due to the high toxicity and rapid
degradation of thes...
Somatic mutation and recombination test in Drosophila melanogaster
Wiley - Tập 6 Số 2 - Trang 153-188 - 1984
AbstractA novel test system for the detection of mutagenic and recombinogenic
activity of chemicals is described in detail. Drosophila melanogaster larvae
trans‐heterozygous for the mutations multiple wing hairs (mwh) and flare (fir)
are exposed to the test compounds for various periods of time ranging from 96 hr
to 1 hr. Induced mutations are detected as single mosaic spots on the wing blade
of s...
Pesticide‐induced complete and partial chromosome loss in screens with repair‐defective females of drosophila melanogaster
Wiley - Tập 5 Số 6 - Trang 835-846 - 1983
AbstractCommercial preparation of fungicides (captan and maneb), herbicides
(bromacil, paraquat, picloram, and 2,4‐D), and insecticides (carbaryl,
chlorpyrifos, dimethoate, DDT, diazinon, carbofuran, and permethrin) were tested
for their ability to induce complete and partial chromosome losses in Drosophila
melanogaster males. In an attempt to identify the mutagenic activity of
pesticides that are...
Sister chromatid exchange and chromosome aberration analyses in mice after in vivo exposure to acrylonitrile, styrene, or butadiene monoxide
Wiley - Tập 8 Số 3 - Trang 439-448 - 1986
AbstractThe use of polymers in plastic and rubber products has generated concern
that monomers potentially active in biological systems may be eluted from these
substances. We have evaluated two such monomers, acrylonitrile and styrene, for
the induction of chromosome damage in mice. Butadiene monoxide, a presumed
metabolite of a third important monomer, 1,3‐butadiene, was also tested. These
chemi...
Chromosome aberrations and sister chromatid exchanges in styrene‐exposed workers with reference to their smoking habits
Wiley - Tập 5 Số 3 - Trang 299-309 - 1983
AbstractThe incidences of chromosome aberrations and the frequencies of sister
chromatid exchanges (SCE) were investigated in cultured lymphocytes of 18
styrene‐exposed workers in comparison with six controls. There was a marginal
increase in the incidence of structural chromosomal aberrations in
first‐division metaphases in the styrene‐exposed workers, as compared with the
nonexposed controls. Ho...
Glutathione: A protective agent in Salmonella typhimurium and Escherichia coli as measured by mutagenicity and by growth delay assays
Wiley - Tập 8 Số 5 - Trang 659-673 - 1986
AbstractCultures of some aerobically grown strains of Salmonella typhimurium and
Escherichia coli contain up to 24 μM extracellular glutathione (GSH) [Owens RO,
Hartman PE (1985): Environ Mutagen 7(Suppl 3): 47] in addition to having
intracellular GSH concentrations in the millimolar range. The addition of 26 μM
GSH to cultures of Salmonella typhimurium strain TA1534 partially protected the
bacter...
Effect of bacterial concentration on reversions induced in salmonella typhimurium TA1538 by N‐hydroxy‐2‐acetylaminofluorene
Wiley - Tập 5 Số 4 - Trang 565-575 - 1983
AbstractReversions induced by N‐hydroxy‐2‐acetylaminofluorene (N‐OH‐AAF) were
measured in the Salmonella/microsome quantitative plate assay using various
concentrations of Salmonella typhimurium strain TA 1538. The number of induced
revertants increased with an increasing number of bacteria/plate, but the
variation in reversion frequency was not as great as the variation in bacterial
concentration...
The effect of culture conditions and toxicity on the ames salmonella/microsome agar incorporation mutagenicity assay
Wiley - Tập 5 Số 4 - Trang 541-551 - 1983
AbstractVarious methods were used to reconstruct an environment similar to a
chemically bactericidal or bacteriostatic effect in the Ames mutagenicity assay
in order to determine whether a false‐positive result could occur. Neither
population reduction, sonication, nor increased histidine produced an increase
of spurious revertant colonies.
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