The genetic toxicology of metal compounds: I. Induction of λ prophage in <i>E coli</i> WP2<sub>S</sub>(λ)

Wiley - Tập 6 Số 1 - Trang 59-69 - 1984
Toby G. Rossman1, Margarita Molina2, LeRoy W. Meyer2
1Dept. of Environmental Medicines, NYU Medical Center, 550 First Ave., New York, NY 10016
2Department of Environmental Medicine, New York University Medical Center, New York

Tóm tắt

Abstract

A number of metal compounds have been shown to be human carcinogens. Others, while not proven human carcinogens, are able to cause tumors in laboratory animals. Short‐term bacterial assays for genotoxic effects have not been successful in predicting the carcinogenicity of metal compounds. We report here the ability of some metal compounds to cause the induction of λ prophage in E coli WP2S(λ). By far the strongest inducing ability was observed with K2CrO4, followed by Pb(N03)2 > MnCl2 > Ni(OOCCH3)2 > CrCl2 > NaWO4 > Na2MoO4 > KMnO4. With the exception of chromate, long‐term exposures in a narrow, subtoxic dose range were required in order to demonstrate phage induction. A new microtiter assay for λ prophage induction, which incorporates these features, is described. This system also was able to detect very small amounts of organic carcinogens.

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Wiley

Tập 6 Số 1

59-69

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