Ethylene oxide: Evidence of human chromosomal effects
Tóm tắt
Ethylene oxide is a known mutagen as indicated by short‐term testing in vitro and in vivo. Occupational exposure can occur during ethylene oxide gas sterilization of materials for hospital and other use. To study the problem in a hospital sterilization facility where occupational exposure was suspected, epidemiologic, analytic, and bioassay tools were employed. All persons whose work activities involved some aspect of the sterilization process were considered exposed to the gas. Within this group of symptomatic and asymptomatic individuals, chronic and incidental exposure was documented by clinical history. Sister chromatid exchanges were studied in lymphocytes cultured from exposed individuals as well as comparable controls. Four chronically exposed persons who reported upper respiratory and neurologic symptoms were studied in some detail. This group showed significantly increased sister chromatid exchange at three weeks and again at eight weeks after the last known exposure. Another group of eight persons with fewer complaints studied as late as the ninth week showed significantly increased exchanges. Incidental exposure may also increase sister chromatid exchange. The measured maximum concentration of ethylene oxide in the sterilizer room was 36 ppm (within standards set by the Occupational Safety and Health Administration).
Từ khóa
Tài liệu tham khảo
Glaser ZR, 1977, Use of Ethylene Oxide as a Sterilant in Medical Facilities
Gross JA, 1978, Ethylene oxide neuropathy, Neurology, 28, 355
EhrenbergL HallstronT: Haematologic studies on persons occupationally exposed to ethylene oxide. In: International Agency Report; SM 92/26 1967 pp327–334.
Frankel‐Conrat H, 1944, The actions of 1,2‐epoxides on proteins, J Biol Chem, 154, 227, 10.1016/S0021-9258(18)71961-3
Frankel‐Conrat H, 1961, Chemical modification of viral ribonucleic acid. Part 1. Alkylating agents, Biochem Biophys Acta, 49, 165
National Institute for Occupational Safety and Health, 1974, NIOSH Manual of Analytical Methods
Department of Health, Education, and Welfare, 1977, Occupational Diseases: A Guide to Their Recognition, 203
Fujii K, 1969, Carcinogenicity of food additives, pesticides, and drugs, Toxicol Appl Pharmacol, 14, 613
Shiraishi Y, 1972, Chromosomal abnormalities in cultured leucocyte cells from Itai Itai disease patients, Proc Jpn Acad, 48, 248, 10.2183/pjab1945.48.248
Evans HJ, 1975, Symposium of the Society for the Study of Human Biology, 63
Embree JW, 1973, Mutagenicity of ethylene oxide, Toxicol Appl Pharmacol, 33, 172
Taylor JH, 1958, Sister chromatid exchange in tritium‐labelled chromosomes, Genetics, 43, 515, 10.1093/genetics/43.3.515
Clinc MJ, 1975, The White Cell, 247
LevinsonC: “Urgent Alert to Blood Cancer Hazard From Ethylene Oxide.” ICEF circular letter No. 97/78. Geneva: International Federation of Chemical Energy and General Worker's Unions 1978.