Walter de Gruyter GmbH
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Amyloid imaging in Alzheimer’s disease: a potential new era of personalized medicine?
Walter de Gruyter GmbH - Tập 5 - Trang 51-56 - 2014
Recent advances along clinical and neuropathological lines, as well as in our ability to detect the deposition of β-amyloid (Aβ) in vivo using positron emission tomography (PET), have helped redefine Alzheimer’s disease (AD) as a dynamic clinicobiological entity. On the basis of these advances, AD is now conceptualized as a continuum comprising asymptomatic, minimally symptomatic, and dementia pha...... hiện toàn bộ
Lặn nín thở như một phản ứng sinh tồn của não Dịch bởi AI Tóm tắt Các vận động viên lặn nín thở chuyên nghiệp là những vận động viên độc nhất đối mặt với áp lực do sức nước và tình trạng hạ oxy/hypercapnia cực độ trong các lần lặn tối đa. Kỷ lục thế giới hiện tại dành cho nam giới là 214 mét cho độ sâu (Herbert Nitsch, môn lặn nín thở không giới hạn), 11:35 phút cho thời gian (Stephane Mifsud, môn lặn nín thở tĩnh), và 281... ... hiện toàn bộ
Walter de Gruyter GmbH - - 2013
Region-specific neuron and synapse loss in the hippocampus of APPSL/PS1 knock-in mice
Walter de Gruyter GmbH - Tập 4 - Trang 8-19 - 2013
Transgenic mouse models with knock-in (KI) expression of human mutant amyloid precursor protein (APP) and/or human presenilin 1 (PS1) may be helpful to elucidate the cellular consequences of APP and PS1 misprocessing in the aging brain. Age-related alterations in total numbers of neurons and in numbers of synaptophysin-immunoreactive presynaptic boutons (SIPB), as well as the amyloid plaque load w...... hiện toàn bộ
Diffuse disconnectivity in traumatic brain injury: a resting state fMRI and DTI study
Walter de Gruyter GmbH - Tập 3 - Trang 9-14 - 2012
Diffuse axonal injury is a common pathological consequence of Traumatic Brain Injury (TBI). Diffusion Tensor Imaging is an ideal technique to study white matter integrity using the Fractional Anisotropy (FA) index which is a measure of axonal integrity and coherence. There have been several reports showing reduced FA in individuals with TBI, which suggest demyelination or reduced fiber density in ...... hiện toàn bộ
F. K. Studnička (1894): Fishes and amphibians also have the cerebral cortex
Walter de Gruyter GmbH - Tập 2 - Trang 79-89 - 2011
The aim of this paper is to provide translation of probably the first report (Studnička 1894) demonstrating that the telencephalon of all vertebrate taxa (including fishes and amphibians) is characterized by the presence of the cerebral cortex (pallium). This report was one of those initiating a century-long and still not fully resolved discussion concerning homologies of various pallial subdivisi...... hiện toàn bộ
Stem cell therapy for neurological disorders
Walter de Gruyter GmbH - Tập 2 - Trang 319-324 - 2011
Stem cells have long been in focus as potential therapy or even cure for a whole myriad of diseases. Many neurodegenerative disorders, both acute and chronic, are characterized by irreversible neuronal damage and loss, and only a few efficient treatment options exist. In contrast to many other tissues, the potential of self-regeneration of the central nervous system is highly limited. There is hop...... hiện toàn bộ
Deep brain stimulation facilitates memory in a model of Alzheimer’s diseaseAbstract Based on evidence suggesting that deep brain stimulation (DBS) may promote certain cognitive processes, we have been interested in developing DBS as a means of mitigating memory and learning impairments in Alzheimer’s disease (AD). In this study we used an animal model of AD (TgCRND8 mice) to determine the effects of high-frequency stimulation (HFS) on non-... ... hiện toàn bộ
Walter de Gruyter GmbH - - 2010
Pentose-phosphate pathway disruption in the pathogenesis of Parkinson’s disease
Walter de Gruyter GmbH - Tập 5 - Trang 179-184 - 2014
Oxidative stress is known to be a key factor in the pathogenesis of Parkinson’s disease (PD). Neuronal redox status is maintained by glucose metabolism via the pentose-phosphate pathway and it is known that disruption of glucose metabolism is damaging to neurons. Accumulating evidence supports the idea that glucose metabolism is altered in PD and dysregulation of the pentose-phosphate pathway in t...... hiện toàn bộ
G protein co-signaling and challenges for translational research
Walter de Gruyter GmbH - Tập 4 - Trang 66-73 - 2013
The Gq-linked G protein coupled receptors (GPCRs) and their signaling pathways are important clinical targets for the dementia of Alzheimer’s disease and cognitive decline with aging. Gq stimulates phospholipase C-β1 (PLC-β1) activity, increasing levels of inositol-1, 4, 5-trisphosphate (IP3) and diacylglycerol, to initiate mobilization of intracellular Ca2+ and activation of protein kinase C, res...... hiện toàn bộ
Cingulum bundle white matter in MAG-knockout mice
Walter de Gruyter GmbH - Tập 1 - Trang 131-138 - 2010
Myelin associated glycoprotein (MAG) is an oligodendrocyte-derived gene whose expression is decreased in schizophrenia. Several measures of white matter integrity appear abnormal in schizophrenia, specifically in the anterior cingulate gyrus. We studied mice lacking MAG as a potential model of dysmyelination. Using the stereological “Space Balls” method, we estimated myelinated fiber length densit...... hiện toàn bộ
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