Toxicologic Pathology

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Morphogenesis of Postmortem Hepatocyte Vacuolation and Liver Weight Increases in Sprague-Dawley Rats
Toxicologic Pathology - Tập 31 Số 6 - Trang 682-688 - 2003
Xiantang Li, Michael R. Elwell, Anne Ryan, Ricardo Ochoa
Preclinical Safety Evaluation in Rats of a Polymeric Matrix Containing an siRNA Drug Used as a Local and Prolonged Delivery System for Pancreatic Cancer Therapy
Toxicologic Pathology - Tập 44 Số 6 - Trang 856-865 - 2016
Yuval Ramot, Shay Rotkopf, Rachel Malka Gabai, Elina Zorde Khvalevsky, Sofia Muravnik, Gabriela Alejandra Marzoli, Abraham J. Domb, Amotz Shemi, Abraham Nyska
Conventional chemotherapy treatments for pancreatic cancer are mainly palliative. RNA interference (RNAi)-based drugs present the potential for a new targeted treatment. LOcal Drug EluteR (LODERTM) is a novel biodegradable polymeric matrix that shields drugs against enzymatic degradation and releases small interfering RNA (siRNA) against G12D-mutated KRAS (siG12D). si...... hiện toàn bộ
Chemical Hormesis: Its Historical Foundations as a Biological Hypothesis
Toxicologic Pathology - Tập 27 Số 2 - Trang 195-216 - 1999
Edward J. Calabrese, Linda A. Baldwin
Despite the long history of hormesis-related experimental research, no systematic effort to describe its early history has been undertaken. The present paper attempts to reconstruct and assess the early history of such research and to evaluate how advances in related scientific fields affected the course of hormesis-related research. The purpose of this paper is not only to satisfy this g...... hiện toàn bộ
High Molecular Weight Polyethylene Glycol Cellular Distribution and PEG-associated Cytoplasmic Vacuolation Is Molecular Weight Dependent and Does Not Require Conjugation to Proteins
Toxicologic Pathology - Tập 41 Số 7 - Trang 970-983 - 2013
Daniel G. Rudmann, James T. Alston, Jeffrey C. Hanson, Shawn M. Heidel
Conjugation of therapeutic proteins with high molecular weight polyethylene glycols (HMW PEGs) is used to extend the half-life of biologics. To evaluate the effects of HMW PEGs in animals, we used an immunohistochemical procedure to study the tissue distribution and toxicity of unconjugated HMW PEGs in rats given 100 mg/kg 10KPEG, 20KPEG, or ... hiện toàn bộ
An Overview of Current Cytochrome P450 Technology for Assessing the Safety and Efficacy of New Materials
Toxicologic Pathology - Tập 24 Số 1 - Trang 45-57 - 1996
Andrew Parkinson
Studies of xenobiotic biotransformation by in vitro techniques are destined to play an increasingly important role in assessing the safety and efficacy of drugs and other new chemical entities. The first part of this article summarizes some of the in vitro techniques that have been developed to evaluate xenobiotics as inducers of liver microsomal cytochrome P450. The second part provides ...... hiện toàn bộ
Pathophysiology of Cyclooxygenase Inhibition in Animal Models
Toxicologic Pathology - Tập 37 Số 1 - Trang 34-46 - 2009
Smaail Radi
Cyclooxygenase (COX) catalyzes the conversion of arachidonic acid into prostaglandins (PGs), which play a significant role in health and disease in the gastrointestinal tract (GI) and in the renal, skeletal, and ocular systems. COX-1 is constitutively expressed and found in most normal tissues, whereas COX-2 can be expressed at low levels in normal tissues and is highly induced by pro-inf...... hiện toàn bộ
Role of the Blood-Nerve Barrier in Experimental Nerve Edema
Toxicologic Pathology - Tập 18 Số 1_part_2 - Trang 170-185 - 1990
Andrew P. Mizisin, Michael Kalichman, Robert R. Myers, Henry C. Powell
Nerve edema is a common response to the nerve injury seen in many peripheral neuropathies and is an important component of Wallerian degeneration. However, independent pathologic effects of nerve edema that aggravate or induce nerve injury extend the role of edema beyond that of an epiphenomenon of injury. New insights into the mechanism and impact of nerve edema come largely from animal ...... hiện toàn bộ
A Multifaceted Evaluation of Imatinib-induced Cardiotoxicity in the Rat
Toxicologic Pathology - Tập 39 Số 7 - Trang 1091-1106 - 2011
Eugene H. Herman, Alan Knapton, Elliot T. Rosen, Karol L. Thompson, Barry A. Rosenzweig, Joel Estis, Sara J. Agee, Quynh-Anh Lu, John A. Todd, Steven E. Lipshultz, Brian B. Hasinoff, Jun Zhang
Cardiotoxicity was an unanticipated side effect elicited by the clinical use of imatinib (Imb). This toxicity has been examined in only a limited number of experimental studies. The present study sought, by a variety of approaches, to identify important characteristics of Imb-induced cardiac alterations. Male spontaneously hypertensive rats (SHRs) received oral doses of 10, 30, or 50 mg/k...... hiện toàn bộ
Sensitivity of Liver Injury in Heterozygous Sod2 Knockout Mice Treated with Troglitazone or Acetaminophen
Toxicologic Pathology - Tập 37 Số 2 - Trang 193-200 - 2009
Kazunori Fujimoto, Kazuyoshi Kumagai, Kazumi Ito, Shingo Arakawa, Yukio Ando, Sen‐ichi Oda, Takashi Yamoto, Sunao Manabe
Recently, it was reported that the intraperitoneal administration of 30 mg/kg/day troglitazone to heterozygous superoxide dismutase 2 gene knockout (Sod2+/−) mice for twenty-eight days caused liver injury, manifested by increased serum ALT activity and hepatic necrosis. Therefore, we evaluated the reproducibility of troglitazone-induced liver injury in Sod2+/− mice, as well as their valid...... hiện toàn bộ
Review Article: Inhalation Studies in Laboratory Animals—Current Concepts and Alternatives
Toxicologic Pathology - Tập 28 Số 5 - Trang 734-753 - 2000
Jürgen Pauluhn, U. Möhr
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