Chemical Hormesis: Its Historical Foundations as a Biological HypothesisToxicologic Pathology - Tập 27 Số 2 - Trang 195-216 - 1999
Edward J. Calabrese, Linda A. Baldwin
Despite the long history of hormesis-related experimental research, no systematic effort to describe its early history has been undertaken. The present paper attempts to reconstruct and assess the early history of such research and to evaluate how advances in related scientific fields affected the course of hormesis-related research. The purpose of this paper is not only to satisfy this g...... hiện toàn bộ
An Overview of Current Cytochrome P450 Technology for Assessing the Safety and Efficacy of New MaterialsToxicologic Pathology - Tập 24 Số 1 - Trang 45-57 - 1996
Andrew Parkinson
Studies of xenobiotic biotransformation by in vitro techniques are destined to play an increasingly important role in assessing the safety and efficacy of drugs and other new chemical entities. The first part of this article summarizes some of the in vitro techniques that have been developed to evaluate xenobiotics as inducers of liver microsomal cytochrome P450. The second part provides ...... hiện toàn bộ
Pathophysiology of Cyclooxygenase Inhibition in Animal ModelsToxicologic Pathology - Tập 37 Số 1 - Trang 34-46 - 2009
Smaail Radi
Cyclooxygenase (COX) catalyzes the conversion of arachidonic acid into prostaglandins (PGs), which play a significant role in health and disease in the gastrointestinal tract (GI) and in the renal, skeletal, and ocular systems. COX-1 is constitutively expressed and found in most normal tissues, whereas COX-2 can be expressed at low levels in normal tissues and is highly induced by pro-inf...... hiện toàn bộ
Role of the Blood-Nerve Barrier in Experimental Nerve EdemaToxicologic Pathology - Tập 18 Số 1_part_2 - Trang 170-185 - 1990
Andrew P. Mizisin, Michael Kalichman, Robert R. Myers, Henry C. Powell
Nerve edema is a common response to the nerve injury seen in many peripheral neuropathies and is an important component of Wallerian degeneration. However, independent pathologic effects of nerve edema that aggravate or induce nerve injury extend the role of edema beyond that of an epiphenomenon of injury. New insights into the mechanism and impact of nerve edema come largely from animal ...... hiện toàn bộ
A Multifaceted Evaluation of Imatinib-induced Cardiotoxicity in the RatToxicologic Pathology - Tập 39 Số 7 - Trang 1091-1106 - 2011
Eugene H. Herman, Alan Knapton, Elliot T. Rosen, Karol L. Thompson, Barry A. Rosenzweig, Joel Estis, Sara J. Agee, Quynh-Anh Lu, John A. Todd, Steven E. Lipshultz, Brian B. Hasinoff, Jun Zhang
Cardiotoxicity was an unanticipated side effect elicited by the clinical use of imatinib (Imb). This toxicity has been examined in only a limited number of experimental studies. The present study sought, by a variety of approaches, to identify important characteristics of Imb-induced cardiac alterations. Male spontaneously hypertensive rats (SHRs) received oral doses of 10, 30, or 50 mg/k...... hiện toàn bộ
Sensitivity of Liver Injury in Heterozygous Sod2 Knockout Mice Treated with Troglitazone or AcetaminophenToxicologic Pathology - Tập 37 Số 2 - Trang 193-200 - 2009
Kazunori Fujimoto, Kazuyoshi Kumagai, Kazumi Ito, Shingo Arakawa, Yukio Ando, Sen‐ichi Oda, Takashi Yamoto, Sunao Manabe
Recently, it was reported that the intraperitoneal administration of 30 mg/kg/day troglitazone to heterozygous superoxide dismutase 2 gene knockout (Sod2+/−) mice for twenty-eight days caused liver injury, manifested by increased serum ALT activity and hepatic necrosis. Therefore, we evaluated the reproducibility of troglitazone-induced liver injury in Sod2+/− mice, as well as their valid...... hiện toàn bộ