Toxicologic Pathology

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Preclinical Safety Evaluation in Rats of a Polymeric Matrix Containing an siRNA Drug Used as a Local and Prolonged Delivery System for Pancreatic Cancer Therapy
Toxicologic Pathology - Tập 44 Số 6 - Trang 856-865 - 2016
Yuval Ramot, Shay Rotkopf, Rachel Malka Gabai, Elina Zorde Khvalevsky, Sofia Muravnik, Gabriela Alejandra Marzoli, Abraham J. Domb, Amotz Shemi, Abraham Nyska
Conventional chemotherapy treatments for pancreatic cancer are mainly palliative. RNA interference (RNAi)-based drugs present the potential for a new targeted treatment. LOcal Drug EluteR (LODERTM) is a novel biodegradable polymeric matrix that shields drugs against enzymatic degradation and releases small interfering RNA (siRNA) against G12D-mutated KRAS (siG12D). si...... hiện toàn bộ
An Overview of Current Cytochrome P450 Technology for Assessing the Safety and Efficacy of New Materials
Toxicologic Pathology - Tập 24 Số 1 - Trang 45-57 - 1996
Andrew Parkinson
Studies of xenobiotic biotransformation by in vitro techniques are destined to play an increasingly important role in assessing the safety and efficacy of drugs and other new chemical entities. The first part of this article summarizes some of the in vitro techniques that have been developed to evaluate xenobiotics as inducers of liver microsomal cytochrome P450. The second part provides ...... hiện toàn bộ
Pathophysiology of Cyclooxygenase Inhibition in Animal Models
Toxicologic Pathology - Tập 37 Số 1 - Trang 34-46 - 2009
Smaail Radi
Cyclooxygenase (COX) catalyzes the conversion of arachidonic acid into prostaglandins (PGs), which play a significant role in health and disease in the gastrointestinal tract (GI) and in the renal, skeletal, and ocular systems. COX-1 is constitutively expressed and found in most normal tissues, whereas COX-2 can be expressed at low levels in normal tissues and is highly induced by pro-inf...... hiện toàn bộ
Sensitivity of Liver Injury in Heterozygous Sod2 Knockout Mice Treated with Troglitazone or Acetaminophen
Toxicologic Pathology - Tập 37 Số 2 - Trang 193-200 - 2009
Kazunori Fujimoto, Kazuyoshi Kumagai, Kazumi Ito, Shingo Arakawa, Yukio Ando, Sen‐ichi Oda, Takashi Yamoto, Sunao Manabe
Recently, it was reported that the intraperitoneal administration of 30 mg/kg/day troglitazone to heterozygous superoxide dismutase 2 gene knockout (Sod2+/−) mice for twenty-eight days caused liver injury, manifested by increased serum ALT activity and hepatic necrosis. Therefore, we evaluated the reproducibility of troglitazone-induced liver injury in Sod2+/− mice, as well as their valid...... hiện toàn bộ
Alterations in Microtubules, Intermediate Filaments, and Microfilaments Induced by Microcystin-LR in Cultured Cells
Toxicologic Pathology - Tập 23 Số 3 - Trang 326-337 - 1995
Mark Wickstrom, S A Khan, Wanda M. Haschek, John F. Wyman, John Eriksson, David J. Schaeffer, Val R. Beasley
Microcystin-LR (MCLR) is a cyanobacterial hepatotoxin that inhibits intracellular serine/threonine protein phosphatases causing disruption of actin microfilaments (MFs) and intermediate filaments (IFs) in hepatocytes. This study compared the effects of MCLR on the organization of MFs, IFs, and microtubules (MTs) in hepatocytes and nonhepatocyte cell lines and determined the sequence of to...... hiện toàn bộ
Detoxification of Genotoxic Compounds as a Threshold Mechanism Limiting Their Carcinogenicity
Toxicologic Pathology - Tập 12 Số 4 - Trang 337-343 - 1984
Silvio De Flora
In vitro metabolic trends were assessed for 100 genotoxic agents detected in two bacterial test systems, i.e., the Ames reversion test and a liquid DNA-repair test in Escherichia coli. Seventy-five compounds were found to undergo a more or less pronounced decrease of genotoxicity, in at least one of these models, in the presence of rat liver homogenates or in other metabolic systems (up t...... hiện toàn bộ
Introduction to Currently Applied Device Pathology
Toxicologic Pathology - Tập 47 Số 3 - Trang 221-234 - 2019
Molly C. Friedemann, Nicole A. Mehta, Staci L. Jessen, Fatima H. Charara, Anne‐Marie Ginn‐Hedman, Courtney N. Kaulfus, Breanna F. Brocklesby, Cedric B. Robinson, Steven Jokerst, Alan Glowczwski, Fred J. Clubb, Brad R. Weeks
Pathologic evaluation is crucial to the study of medical devices and integral to the Food and Drug Administration and other regulatory entities’ assessment of device safety and efficacy. While pathologic analysis is tailored to the type of device, it generally involves at a minimum gross and microscopic evaluation of the medical device and associated tissues. Due to the complex nature of ...... hiện toàn bộ
A Spontaneous Teratocarcinoma in the Testis of a Swiss Albino Mouse
Toxicologic Pathology - Tập 39 Số 2 - Trang 414-417 - 2011
S.B. Jamadagni, Pallavi Shrirang Jamadagni, S. N. Upadhyay, Sudesh N. Gaidhani, Jayram Hazra
A unilateral non-metastatic embryonal carcinoma and teratoma of the testis was observed in a 12-week-old Swiss Albino mouse at the end of a 28-day repeated dose toxicity study. The teratocarcinoma almost completely replaced the parenchyma of the left testis. The tumor was composed of sheets and rosettes of primitive embryonal cells, anaplastic cells, skeletal muscle tissue, sebaceous glan...... hiện toàn bộ
A Review of Unique Male Rat Hydrocarbon Nephropathy
Toxicologic Pathology - Tập 14 Số 1 - Trang 109-111 - 1986
Carl L. Alden
There is a diverse group of hydrocarbons that induce a specific spectrum of nephropathic alterations. Examples include decalin, an alicyclic hydrocarbon; JP5 jet fuel, a mixture of C12–13 straight and branched chain hydrocarbons; C10–11 isoparaffinic hydrocarbons; Stoddard solvent, a mixture of straight and branched-chain paraffins, naphthenes, an...... hiện toàn bộ
Đánh giá an toàn trước lâm sàng của rhuMAbVEGF, một kháng thể đơn dòng nhân hóa chống sinh mạch Dịch bởi AI
Toxicologic Pathology - Tập 27 Số 1 - Trang 78-86 - 1999
Anne Ryan, Dorothy Bates Eppler, Kelly E. Hagler, Richard H. Bruner, Peter J. Thomford, Robert L. Hall, George M. Shopp, Charles O’Neill
Kháng thể đơn dòng IgG nhân hóa chống yếu tố tăng trưởng nội mạch (rhuMAbVEGF) đang được phát triển như một tác nhân chống sinh mạch để điều trị nhiều loại u rắn. Các nghiên cứu an toàn tiền lâm sàng bao gồm nghiên cứu độ tương tác chéo của mô bằng miễn dịch hóa học, nghiên cứu tiềm năng ly giải in vitro và tính tương thích với máu, cùng các nghiên cứu độc tính nhiều liều. Các nghiên cứu ...... hiện toàn bộ
#rhuMAbVEGF #kháng thể đơn dòng #chống sinh mạch #u rắn #nghiên cứu độc tính #khỉ cynomolgus
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