Thrombosis and Haemostasis

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Detection and Quantitative Evaluation of Lupus Circulating Anticoagulant Activity
Thrombosis and Haemostasis - Tập 57 Số 02 - Trang 144-147 - 1987
Esther Rosner, Rachel Pauzner, Ayala Lusky, Michaela Modan, Amira Many
SummarySixty-six SLE patients were studied for the presence of lupus type circulating anticoagulant. Forty-nine percent of them showed activity of this anticoagulant. The sensitivity of various coagulation tests was compared. Recalcification time was found to be the most sensitive screening test and the kaolin clotting time mixture test, the best for determining the presence of the anticoagulant.T... hiện toàn bộ
The role of microRNAs in arterial remodelling
Thrombosis and Haemostasis - Tập 107 Số 04 - Trang 611-618 - 2012
Maliheh Nazari-Jahantigh, Yuanyuan Wei, Andreas Schober
SummaryAdaptive alterations of the vessel wall architecture, called vascular remodelling, can be found in arterial hypertension, during the formation of aneurysms, in restenosis after vascular interventions, and in atherosclerosis. MicroRNAs (miR) critically affect the main cellular players in arterial remodelling and may either promote or inhibit the structural changes in the vessel wall. They re... hiện toàn bộ
Characterization of Cellular Binding Sites and Interactive Regions within Reactants Required for Enhancement of Plasminogen Activation by tPA on the Surface of Leukocytic Cells
Thrombosis and Haemostasis - Tập 76 Số 04 - Trang 577-584 - 1996
J Félez, Lindsey A. Miles, Pere Fábregas, Mercè Jardı́, Edward F. Plow, Roger Lijnen
SummaryPlasminogen and tPA bind to a common set of binding sites on nucleated cells. To assess the functional consequences of cellular binding, we have measured the kinetic changes induced by plasminogen activation by tPA on cell surfaces. These studies were carried out with U937 and THP-1 monocytoid cells, with Raji, Nalm6 and Molt4 lymphoid cells and with peripheral blood monocytes and neutrophi... hiện toàn bộ
A Common Thrombomodulin Amino Acid Dimorphism Is Associated with Myocardial Infarction
Thrombosis and Haemostasis - Tập 77 Số 02 - Trang 248-251 - 1997
Lena Norlund, Johan Holm, Henrik Ohlsson, Ann-Kristin Öhlin
SummaryEndothelial dysfunction and haemostatic imbalance are believed to be important aetiological factors in the development of acute coronary syndromes. Thrombomodulin (TM) is an integral membrane protein crucial for normal endothelial function and activation of the protein C anticoagulant pathway. We have investigated the importance of a common C/T dimorphism in the TM gene (nucleotide 1418) fo... hiện toàn bộ
Thrombomodulin Gene Defects in Families with Thromboembolic Disease – A Report on Four Families
Thrombosis and Haemostasis - Tập 81 Số 03 - Trang 338-344 - 1999
Ann-Kristin Öhlin, Richard A. Marlar
SummaryIt has been suggested that an impaired thrombomodulin (TM) function could constitute an abnormality leading to thromboembolic disease (TED). The TM gene from 51 unrelated American patients with TED and 100 American blood donors was screened for mutations. Four heterozygous point mutations in the TM gene were detected. The mutations are distributed throughout the TM gene and predict amino ac... hiện toàn bộ
A Mutation in the Thrombomodulin Gene, 127G to A Coding for Ala25Thr, and the Risk of Myocardial Infarction in Men
Thrombosis and Haemostasis - Tập 80 Số 11 - Trang 743-748 - 1998
Catharina Jacoba Maria Doggen, G Kunz, F.R. Rosendaal, David A. Lane, Hans L. Vos, P J Stubbs, V. Manger Cats, H Ireland
SummaryThrombomodulin is an endothelial cell surface receptor that transforms the procoagulant thrombin into an anticoagulant. A mutation in the thrombomodulin gene is a potential risk factor for venous and arterial thrombosis.We screened a region within the coding sequence of the thrombomodulin gene by single-strand conformation polymorphism analysis (SSCP) in a pilot study of 104 patients with m... hiện toàn bộ
Maternal Lupus Anticoagulant and Fatal Neonatal Thrombosis
Thrombosis and Haemostasis - Tập 57 Số 02 - Trang 238-238 - 1987
Guido Finazzi, Sergio Cortelazzo, Piera Viero, Monica Galli, Tiziano Barbui
Is EPCR a multi-ligand receptor? Pros and cons
Thrombosis and Haemostasis - Tập 107 Số 05 - Trang 815-826 - 2012
Ramón Montes, Cristina Puy, Eva Molina, José Hermida
SummaryIn the last decade, the endothelial cell protein C/activated protein C receptor (EPCR) has received considerable attention. The role initially attributed to EPCR, i.e. the enhancement of protein C (PC) activation by the thrombin-thrombomodulin complex on the surface of the large vessels, although important, did not go beyond the haemostasis scenario. However, the discovery of the cytoprotec... hiện toàn bộ
Association between cardiovascular disease risk factors and occurrence of venous thromboembolism
Thrombosis and Haemostasis - Tập 108 Số 09 - Trang 508-515 - 2012
Pamela L. Lutsey, Heather L. Gornik, Mary Cushman, Wayne D. Rosamond, Aaron R. Folsom, Keattiyoat Wattanakit
SummaryApart from obesity, it remains controversial whether atherosclerosis and its cardiovascular risk disease (CVD) factors are associated with risk of venous thromboembolism (VTE). Using data from the Atherosclerosis Risk in Communities study (ARIC), we evaluated associations between CVD risk factors and incident VTE in a cohort of 15,340 participants who were free a history of VTE and/or antic... hiện toàn bộ
Plasmin và Matrix Metalloproteinases trong Tái Cấu Trúc Mạch Máu Dịch bởi AI
Thrombosis and Haemostasis - Tập 86 Số 07 - Trang 324-333 - 2001
Claude Boucheix
Tóm tắtTái cấu trúc mạch máu, được định nghĩa là những thay đổi cấu trúc lâu dài trong thành mạch để phản ứng với các kích thích huyết động, đóng vai trò trong nhiều quá trình (bệnh lý) sinh lý yêu cầu sự di cư của tế bào và phân hủy ma trận ngoại bào (ECM). Hai hệ thống phân hủy protein, hệ thống fibrinolytic (plasminogen/plasmin) và hệ thống metalloproteinase ma trận (MMP) có thể phân hủy hầu hế... hiện toàn bộ
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