Thrombosis and Haemostasis

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Impact of proton pump inhibitors on the antiplatelet effects of clopidogrel
Thrombosis and Haemostasis - Tập 101 Số 04 - Trang 714-719 - 2009
Dirk Sibbing, Tanja Morath, Julia Stegherr, Siegmund Braun, Wolfgang Vogt, Martin Hadamitzky, Albert Schömig, Adnan Kastrati, Nicolas von Beckerath
SummaryPatients receiving dual antiplatelet treatment with aspirin and clopidogrel are commonly treated with proton pump inhibitors (PPIs). Attenuating effects on platelet response to clopidogrel have been reported solely for the PPI omeprazole. PPIs differ in their metabolisation properties as well as their potential for drug-drug interactions. The aim of this stu...... hiện toàn bộ
PDK1 selectively phosphorylates Thr(308) on Akt and contributes to human platelet functional responses
Thrombosis and Haemostasis - Tập 112 Số 03 - Trang 508-517 - 2014
Carol Dangelmaier, Bhanu Kanth Manne, Elizabetta Liverani, Jianguo Jin, Paul F. Bray, Satya P. Kunapuli
Summary3-phosphoinositide-dependent protein kinase 1 (PDK1), a member of the protein A,G and C (AGC) family of proteins, is a Ser/Thr protein kinase that can phosphorylate and activate other protein kinases from the AGC family, including Akt at Thr308, all of which play important roles in mediating cellular responses. The functional role of PDK1 or the importance o...... hiện toàn bộ
Purification and Characterization of a Novel Metalloproteinase, Acurhagin, from Agkistrodon acutus Venom
Thrombosis and Haemostasis - Tập 87 Số 04 - Trang 641-650 - 2002
Wen‐Jeng Wang, Tur‐Fu Huang
SummaryAcurhagin, a high-molecular mass hemorrhagic metalloproteinase, was purified from the crude venom of Agkistrodon acutus using anionexchange and hydrophobic interaction chromatography. Acurhagin is a monomer with a molecular mass of 51.4 kDa under non-reducing conditions on SDS-PAGE and 48,133 Da by mass spectrometry. Partial amino acid sequence of its metall...... hiện toàn bộ
Proteins Secreted by the Platelet
Thrombosis and Haemostasis - Tập 38 Số 04 - Trang 0924-0938 - 1977
Stefan Niewiarowski
Genetic Depletion of Thromboxane A2/Thromboxane-Prostanoid Receptor Signalling Prevents Microvascular Dysfunction in Ischaemia/Reperfusion Injury
Thrombosis and Haemostasis - Tập 118 Số 11 - Trang 1982-1996 - 2018
Chih-Yao Chiang, Chen‐Yen Chien, Wei-Yin Qiou, Christopher Chang, I‐Shing Yu, Po‐Yuan Chang, Chiang‐Ting Chien
Objective Activation of thromboxane A2 synthase (TXAS)/thromboxane A2 (TXA2)/thromboxane prostanoid (TP) receptor leads to arterial constriction, platelet aggregation and vascular injury. We attempted to characterize the microvascular dysfunction in ischaemia/reperfusion injury using genetically modified TXAS−/−, TP−/− and TXAS−/−TP−/− mice. Approa...... hiện toàn bộ
Association of Successful Ultrasound-Accelerated Catheter-Directed Thrombolysis with Postthrombotic Syndrome: A Post Hoc Analysis of the CAVA Trial
Thrombosis and Haemostasis - Tập 120 Số 08 - Trang 1188-1199 - 2020
Pascale Notten, Carsten W. K. P. Arnoldussen, Rutger Brans, A.A.E.A. de Smet, Lidwine W. Tick, Marlène H. W. van de Poel, O.R. Wikkeling, Louis‐Jean Vleming, Ad Koster, Kon‐Siong G. Jie, Esther Jacobs, Harm P. Ebben, R. Nils Planken, Hugo Ten Cate, Cees H.A. Wittens, Arina J. ten Cate‐Hoek
Abstract Background The CAVA trial did not show the anticipated risk reduction for postthrombotic syndrome (PTS) after thrombus removal via additional ultrasound-accelerated catheter-directed thrombolysis (UACDT) in patients with acute iliofemoral deep vein thrombosis (IFDVT). Difficulties in achieving an effective degree of recanalization through thrombo...... hiện toàn bộ
A global assay of haemostasis which uses recombinant tissue factor and tissue-type plasminogen activator to measure the rate of fibrin formation and fibrin degradation in plasma
Thrombosis and Haemostasis - Tập 98 Số 10 - Trang 871-882 - 2007
Kun Zhu, Mika Skeppholm, Jenny Vedin, Jan Svensson, Nils Egberg, Margareta Blombäck, Shu He
SummaryThe global assay of Overall Haemostasis Potential we previously described has been refined. The coagulation cascade in plateletpoor plasma is triggered by adding a minimal dose of recombinant tissue factor together with purified phospholipids and calcium; fibrinolysis is initiated by adding recombinant tissue type-plasminogen activator in a concentration sim...... hiện toàn bộ
Inventory of Haemorrhagic Factors from Snake Venoms
Thrombosis and Haemostasis - Tập 71 Số 06 - Trang 793-797 - 1994
Neville Marsh
Seasonal and monthly variability in the incidence of venous thromboembolism
Thrombosis and Haemostasis - Tập 106 Số 09 - Trang 439-447 - 2011
Walter Ageno, Elena Rancan, Alberto Donati, Luca Galli, Alessandro Squizzato, Achille Venco, Pier Mannuccio Mannucci, Roberto Manfredini, Francesco Dentali
SummaryMany studies showed that the occurrence of cardiovascular and cerebrovascular events exhibits a seasonal and monthly variation. Evidences of a seasonal and monthly variation in the incidence of venous thromboembolism (VTE) are more conflicting. We conducted a systematic review and a meta-analysis of the literature to assess the presence of an infradian rhyth...... hiện toàn bộ
Live birth following the first mutation specific pre-implantation genetic diagnosis for haemophilia A
Thrombosis and Haemostasis - Tập 95 Số 02 - Trang 373-379 - 2006
K Michaelides, Edward G. D. Tuddenham, C. Turner, Ben Lavender, Stuart Lavery
SummaryHaemophilia A is an X-linked, recessive, inherited bleeding disorder which affects 1 in 5000 males born worldwide. It is caused by mutations in the FactorVIII (F8) gene on chromosome Xq28. We describe for the first time two mutation specific, single cell protocols for pre-implantation genetic diagnosis (PGD) of haemophilia A that enable the selection of both...... hiện toàn bộ
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