Is EPCR a multi-ligand receptor? Pros and cons

Thrombosis and Haemostasis - Tập 107 Số 05 - Trang 815-826 - 2012
Ramón Montes1, Cristina Puy, Eva Molina1, José Hermida
1Division of Cardiovascular Sciences, Laboratory of Thrombosis and Haemostasis, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain. [email protected]

Tóm tắt

SummaryIn the last decade, the endothelial cell protein C/activated protein C receptor (EPCR) has received considerable attention. The role initially attributed to EPCR, i.e. the enhancement of protein C (PC) activation by the thrombin-thrombomodulin complex on the surface of the large vessels, although important, did not go beyond the haemostasis scenario. However, the discovery of the cytoprotective, anti-inflammatory and anti-apoptotic features of the activated PC (APC) and the required involvement of EPCR for APC to exert such actions did place the receptor in a privileged position in the crosstalk between coagulation and inflammation. The last five years have shown that PC/APC are not the only molecules able to interact with EPCR. Factor VII/VIIa (FVII/VIIa) and factor Xa (FXa), two other serine proteases that play a central role in haemostasis and are also involved in signalling processes influencing wound healing, tissue remodelling, inflammation or metastasis, have been reported to bind to EPCR. These observations have paved the way for an exploration of unsuspected new roles for the receptor. This review aims to offer a new image of EPCR in the light of its extended panel of ligands. A brief update of what is known about the APC-evoked EPCR-dependent cell signalling mechanisms is provided, but special care has been taken to assemble all the information available about the interaction of EPCR with FVII/VIIa and FXa.

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Tài liệu tham khảo

Fukudome, 1994, J Biol Chem, 269, 26486, 10.1016/S0021-9258(18)47220-1

10.1074/jbc.270.10.5571

10.1074/jbc.271.29.17491

Crawley, 2002, Thromb Haemost, 88, 259, 10.1055/s-0037-1613196

Laszik, 1997, Circulation, 96, 3633, 10.1161/01.CIR.96.10.3633

10.1073/pnas.93.19.10212

10.1073/pnas.0611493104

10.1074/jbc.272.42.26279

10.1182/blood.V97.6.1685

10.1160/TH09-11-0750

10.1182/blood-2004-03-0793

10.1111/j.1538-7836.2005.01297.x

10.1111/j.1538-7836.2007.02582.x

Castellino, 2002, Thromb Haemost, 88, 462, 10.1055/s-0037-1613239

10.1111/j.1538-7836.2008.03118.x

10.1182/blood-2010-05-283739

Biguzzi, 2001, Thromb Haemost, 86, 945, 10.1055/s-0037-1616515

Medina, 2004, Thromb Haemost, 91, 905, 10.1160/TH03-10-0657

10.1182/blood-2003-07-2520

10.1046/j.1538-7836.2004.00855.x

Medina, 2005, Thromb Haemost, 94, 389, 10.1160/TH05-02-0089

10.1016/j.atherosclerosis.2005.02.028

10.3324/haematol.12448

10.3324/haematol.13066

Pomp, 2009, Thromb Haemost, 101, 62, 10.1160/TH08-08-0502

Cochery-Nouvellon, 2009, Thromb Haemost, 102, 656, 10.1160/TH-09-04-0224

10.1111/j.1365-2141.2009.07612.x

Medina, 2007, Thromb Haemost, 98, 564, 10.1160/TH07-01-0071

10.1016/j.thromres.2011.08.001

10.1056/NEJM200103083441001

Taylor, 1991, Blood, 78, 364, 10.1182/blood.V78.2.364.364

10.1001/jama.286.15.1869

Taylor, 2000, Blood, 95, 1680, 10.1182/blood.V95.5.1680.005k33_1680_1686

10.1111/j.1365-2141.2009.08020.x

10.1111/j.1476-5381.2009.00251.x

Toltl, 2008, Thromb Haemost, 100, 582, 10.1160/TH08-03-0159

10.1074/jbc.C100017200

10.1126/science.1071699

10.1097/00003246-200205001-00019

10.1038/nm826

10.1161/01.CIR.0000146344.49689.BB

10.1074/jbc.M500747200

Brueckmann, 2005, Thromb Haemost, 93, 743, 10.1160/TH04-08-0511

10.1111/j.1365-2141.2006.06059.x

10.1182/blood-2006-09-003004

10.1074/jbc.M600506200

10.1016/0092-8674(91)90261-V

10.1074/jbc.M410381200

Bae, 2008, Thromb Haemost, 100, 101, 10.1160/TH08-02-0127

Bae, 2009, Thromb Haemost, 101, 513, 10.1160/TH08-09-0568

10.1016/j.thromres.2009.07.015

Bae, 2010, J Thromb Haemost, 8, 1107, 10.1111/j.1538-7836.2010.03812.x

10.1002/jcp.22249

10.1182/blood-2007-06-096651

10.1182/blood-2011-06-360701

Soh UJ, Trejo J. Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through β-arrestin and dishevelled-2 scaffolds. Proc Natl Acad Sci USA 2011; epub ahead of print.

10.1182/blood-2007-09-113076

Shibata, 2001, Circulation, 103, 1799, 10.1161/01.CIR.103.13.1799

10.1182/blood-2002-12-3680

10.1002/ana.20602

10.1038/nm1122

10.1038/nm1498

10.1038/nm1667

Madhusudhan T, et al. Cytoprotective signaling by activated protein C requires protease activated receptor-3 in podocytes. Blood 2011; epub ahead of print.

10.1182/blood-2004-10-3985

10.1074/jbc.M412427200

10.1096/fj.09-134445

Schuepbach, 2009, Thromb Haemost, 101, 724, 10.1160/TH08-10-0632

10.1182/blood-2008-05-159434

10.1182/blood-2009-04-217679

Nold, 2007, Thromb Haemost, 98, 1118, 10.1160/TH07-01-0052

10.1160/TH11-06-0438

10.1111/j.1538-7836.2009.03333.x

Frommhold D, et al. Protein C concentrate controls leukocyte recruitment during inflammation and improves survival during endotoxemia after efficient in vivo activation. Am J Pathol 2011; epub ahead of print.

10.1111/j.1538-7836.2007.02592.x

10.1182/blood-2004-06-2456

10.1182/blood-2006-06-032086

10.1172/JCI31027

Cabello-Gutiérrez, 2009, Thromb Haemost, 101, 916, 10.1160/TH08-04-0271

10.4049/jimmunol.1101125

Martí-Carvajal, 2011, Cochrane Database Syst Rev, 4, CD004388

10.1182/blood-2004-01-0110

10.1074/jbc.M610547200

10.1074/jbc.M702131200

10.1084/jem.20070404

10.1172/JCI42629

10.1165/rcmb.2010-0397OC

10.1111/j.1460-9568.2009.06664.x

10.1111/j.1471-4159.2009.05921.x

10.1038/jcbfm.2008.117

10.1160/TH11-08-0522

10.1182/blood-2009-03-208900

Stephenson, 2006, J Immunol, 177, 2115, 10.4049/jimmunol.177.4.2115

10.1136/ard.2006.068239

Toltl LJ, et al.; Canadian Critical Care Translational Biology Group. Activated protein C up-regulates IL-10 and inhibits tissue factor in blood monocytes. J Immunol 2008; 181: 2165-2173.

Feistritzer, 2006, J Immunol, 176, 1019, 10.4049/jimmunol.176.2.1019

10.1182/blood-2002-12-3880

10.1111/j.1538-7836.2005.01635.x

10.1111/j.0022-202X.2005.23952.x

10.1074/jbc.M610740200

10.1074/jbc.M110.181388

Julovi SM, et al. Protease Activated Receptor-2 Mediates Activated Protein C-Induced Cutaneous Wound Healing via Inhibition of p38. Am J Pathol 2011; epub ahead of print.

10.1111/j.1582-4934.2008.00359.x

10.1002/art.24303

10.1016/j.thromres.2009.09.005

10.1111/j.1538-7836.2011.04331.x

10.1161/01.RES.0000255685.06922.c7

10.1074/jbc.C200163200

10.1111/j.1538-7836.2007.02648.x

10.1074/jbc.M010572200

10.1016/j.pep.2008.11.002

10.1182/blood-2005-01-0406

10.1086/656787

10.1074/jbc.M604966200

10.1074/jbc.M609283200

10.1046/j.1537-2995.2002.00017.x

10.1046/j.1538-7836.2003.00059.x

10.1021/bi951768c

10.1111/j.1365-2141.2009.08060.x

10.1532/IJH97.03167

10.1073/pnas.93.25.14379

10.1172/JCI119548

10.1111/j.1538-7836.2007.02347.x

10.1182/blood-2007-08-104968

10.3324/haematol.12376

10.1046/j.1538-7836.2003.t01-4-00115.x

Kurosawa, 1998, Blood, 91, 725, 10.1182/blood.V91.2.725

10.1111/j.1523-1755.2005.00385.x

Medina, 2004, Thromb Haemost, 91, 905, 10.1160/TH03-10-0657

10.1182/blood-2003-07-2520

10.1161/CIRCULATIONAHA.109.869156

10.1161/ATVBAHA.109.191551

10.1182/blood-2010-09-310706

10.1111/j.1538-7836.2011.04295.x

10.1074/jbc.M110.201228

10.1111/j.1538-7836.2009.03682.x

10.1182/blood-2011-05-354571

10.1161/CIRCRESAHA.107.167759

10.1074/jbc.M110.163642

Disse J, Ruf W. The endothelial protein C receptor is required for tissue factor ternary complex signaling in the mouse. J Thromb Haemost 2011 epub ahead of print.

10.1074/jbc.271.45.28168

10.1016/S1050-1738(02)00153-6

Mackman N. The many faces of tissue factor. J Thromb Haemost 2009;7 Suppl 1: 136-9.

10.1161/ATVBAHA.108.177428

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Thrombosis and Haemostasis

Tập 107 Số 05

815-826

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