The Journal of Membrane Biology

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Melatonin Enhances Tamoxifen's Ability to Prevent the Reduction in Microsomal Membrane Fluidity Induced by Lipid Peroxidation
The Journal of Membrane Biology - Tập 162 - Trang 59-65 - 1998
J.J. García, R.J. Reiter, G.G. Ortiz, C.S. Oh, L. Tang, B.P. Yu, G. Escames
The indoleamine melatonin and the synthetic antiestrogenic drug tamoxifen seem to have similar mechanisms in inhibiting the growth of estrogen receptor positive breast cancer cells. In this study, we compared the ability of these molecules, alone and in combination, in stabilizing microsomal membranes against free radical attack. Hepatic microsomes were obtained from male rats and incubated with ...... hiện toàn bộ
Lipid-Membrane Affinity of Chimeric Metal-binding Green Fluorescent Protein
The Journal of Membrane Biology - Tập 200 - Trang 47-56 - 2004
V. Prachayasittikul, C. Isarankura Na Ayudhya, S. Boonpangrak, H.-J. Galla
The Green Fluorescent Protein (GFP) is a useful marker to trace the expression of cellular proteins. However, little is known about changes in protein interaction properties after fusion to GFP. In this study, we present evidence for a binding affinity of chimeric cadmium-binding green fluorescent proteins to lipid membrane. This affinity has been observed in both cellular membranes and artificial...... hiện toàn bộ
Cytoplasmic Determinants of Piperidine Blocking Affinity for N-type Calcium Channels
The Journal of Membrane Biology - - 1999
Gerald W. Zamponi
Phosphatidylcholine-fatty Alcohols Equilibria in Monolayers at the Air/Water Interface
The Journal of Membrane Biology - Tập 248 - Trang 767-773 - 2015
Agnieszka Serafin, Zbigniew Artur Figaszewski, Aneta Dorota Petelska
Monolayers of phosphatidylcholine (PC), tetradecanol (TD), hexadecanol (HD), octadecanol (OD) and eicosanol (E) and their binary mixtures were investigated at the air/water interface. The surface tension values of pure and mixed monolayers were used to calculate π–A isotherms. The surface tension measurements were carried out at 22 °C using a Teflon trough and a Nima 9000 tensiometer. The interact...... hiện toàn bộ
Conformational analysis of d-tubocurarine: Implications for minimal dimensions of its binding site within ion channels
The Journal of Membrane Biology - Tập 135 - Trang 19-26 - 1993
Boris S. Zhorov, Nina B. Brovtsyna
All the minimum-energy conformations of d-tubocurarine were calculated by the method of molecular mechanics. The energy was minimized from 413 closed forms of the 18-member ring. The set of minimum-energy conformations includes 10 forms with energies less than 6 kcal/mol from the most stable one. Among the four lowest minimum-energy conformations, two forms correspond to those known from X-ray stu...... hiện toàn bộ
Protamine alters structure and conductance ofNecturus gallbladder tight junctions without major electrical effects on the apical cell membrane
The Journal of Membrane Biology - - 1987
Carl J. Bentzel, Michael Fromm, Carlos E. Palant, Ulrich Hegel
Na,K-ATPase in the Nuclear Envelope Regulates Na+: K+ Gradients in Hepatocyte Nuclei
The Journal of Membrane Biology - Tập 187 - Trang 97-115 - 2002
M.H. Garner
Role of passive potassium fluxes in cell volume regulation in cultured HeLa cells
The Journal of Membrane Biology - Tập 87 - Trang 93-105 - 1985
D. R. Tivey, N. L. Simmons, J. F. Aiton
Cultured HeLa cells behave as ideal osmometers when subjected to hyperosmolar media, and show no volume regulatory behavior. In hypoosmolar solutions, cell swelling is not as great as predicted, and this is due largely to a loss of intracellular KCl. In hyperosmolar solutions there is a stimulation of the ouabain-insensitive but loop diuretic-sensitive86Rb+ (K+) pathway. Analysis of the K+, Na+ an...... hiện toàn bộ
Pharmacological Properties and Physiological Function of a P2X-Like Current in Single Proximal Tubule Cells Isolated from Frog Kidney
The Journal of Membrane Biology - Tập 237 - Trang 79-91 - 2010
John P. Davies, Louise Robson
Although previous studies have provided evidence for the expression of P2X receptors in renal proximal tubule, only one cell line study has provided functional evidence. The current study investigated the pharmacological properties and physiological role of native P2X-like currents in single frog proximal tubule cells using the whole-cell patch-clamp technique. Extracellular ATP activated a cation...... hiện toàn bộ
Associated Proteins and Renal Epithelial Na+ Channel Function
The Journal of Membrane Biology - Tập 149 - Trang 123-132 - 1996
I.I. Ismailov, B.K. Berdiev, A.L. Bradford, M.S. Awayda, C.M. Fuller, D.J. Benos
The hypothesis that amiloride-sensitive Na+ channel complexes immunopurified from bovine renal papillary collecting tubules contain, as their core conduction component, an ENaC subunit, was tested by functional and immunological criteria. Disulfide bond reduction with dithiothreitol (DTT) of renal Na+ channels incorporated into planar lipid bilayers caused a reduction of single channel conductanc...... hiện toàn bộ
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