The Journal of Membrane Biology
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Melatonin Enhances Tamoxifen's Ability to Prevent the Reduction in Microsomal Membrane Fluidity Induced by Lipid Peroxidation
The Journal of Membrane Biology - Tập 162 - Trang 59-65 - 1998
The indoleamine melatonin and the synthetic antiestrogenic drug tamoxifen seem
to have similar mechanisms in inhibiting the growth of estrogen receptor
positive breast cancer cells. In this study, we compared the ability of these
molecules, alone and in combination, in stabilizing microsomal membranes against
free radical attack. Hepatic microsomes were obtained from male rats and
incubated with o...
Lipid-Membrane Affinity of Chimeric Metal-binding Green Fluorescent Protein
The Journal of Membrane Biology - Tập 200 - Trang 47-56 - 2004
The Green Fluorescent Protein (GFP) is a useful marker to trace the expression
of cellular proteins. However, little is known about changes in protein
interaction properties after fusion to GFP. In this study, we present evidence
for a binding affinity of chimeric cadmium-binding green fluorescent proteins to
lipid membrane. This affinity has been observed in both cellular membranes and
artificial...
Cytoplasmic Determinants of Piperidine Blocking Affinity for N-type Calcium Channels
The Journal of Membrane Biology - - 1999
Phosphatidylcholine-fatty Alcohols Equilibria in Monolayers at the Air/Water Interface
The Journal of Membrane Biology - Tập 248 - Trang 767-773 - 2015
Monolayers of phosphatidylcholine (PC), tetradecanol (TD), hexadecanol (HD),
octadecanol (OD) and eicosanol (E) and their binary mixtures were investigated
at the air/water interface. The surface tension values of pure and mixed
monolayers were used to calculate π–A isotherms. The surface tension
measurements were carried out at 22 °C using a Teflon trough and a Nima 9000
tensiometer. The interact...
Conformational analysis of d-tubocurarine: Implications for minimal dimensions of its binding site within ion channels
The Journal of Membrane Biology - Tập 135 - Trang 19-26 - 1993
All the minimum-energy conformations of d-tubocurarine were calculated by the
method of molecular mechanics. The energy was minimized from 413 closed forms of
the 18-member ring. The set of minimum-energy conformations includes 10 forms
with energies less than 6 kcal/mol from the most stable one. Among the four
lowest minimum-energy conformations, two forms correspond to those known from
X-ray stu...
Protamine alters structure and conductance ofNecturus gallbladder tight junctions without major electrical effects on the apical cell membrane
The Journal of Membrane Biology - - 1987
Na,K-ATPase in the Nuclear Envelope Regulates Na+: K+ Gradients in Hepatocyte Nuclei
The Journal of Membrane Biology - Tập 187 - Trang 97-115 - 2002
Role of passive potassium fluxes in cell volume regulation in cultured HeLa cells
The Journal of Membrane Biology - Tập 87 - Trang 93-105 - 1985
Cultured HeLa cells behave as ideal osmometers when subjected to hyperosmolar
media, and show no volume regulatory behavior. In hypoosmolar solutions, cell
swelling is not as great as predicted, and this is due largely to a loss of
intracellular KCl. In hyperosmolar solutions there is a stimulation of the
ouabain-insensitive but loop diuretic-sensitive86Rb+ (K+) pathway. Analysis of
the K+, Na+ an...
Pharmacological Properties and Physiological Function of a P2X-Like Current in Single Proximal Tubule Cells Isolated from Frog Kidney
The Journal of Membrane Biology - Tập 237 - Trang 79-91 - 2010
Although previous studies have provided evidence for the expression of P2X
receptors in renal proximal tubule, only one cell line study has provided
functional evidence. The current study investigated the pharmacological
properties and physiological role of native P2X-like currents in single frog
proximal tubule cells using the whole-cell patch-clamp technique. Extracellular
ATP activated a cation...
Interaction of thiourea with band 3 in human red cell membranes
The Journal of Membrane Biology - Tập 85 - Trang 37-48 - 1985
Although urea transport across the human red cell membrane has been studied
extensively, there is disagreement as to whether urea and water permeate the red
cell by the same channel. We have suggested that the red cell anion transport
protein, band 3, is responsible for both water and urea transport. Thiourea
inhibits urea transport and also modulates the normal inhibition of water
transport produ...
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