Minireview: Gut Microbiota: The Neglected Endocrine Organ Tập 28 Số 8 - Trang 1221-1238 - 2014
Gerard Clarke, Roman M. Stilling, Paul J. Kennedy, Catherine Stanton, John F. Cryan, Timothy G. Dinan
The concept that the gut microbiota serves as a virtual endocrine organ arises
from a number of important observations. Evidence for a direct role arises from
its metabolic capacity to produce and regulate multiple compounds that reach the
circulation and act to influence the function of distal organs and systems. For
example, metabolism of carbohydrates results in the production of short-chain
fa... hiện toàn bộ
Endocrine-Disrupting Organotin Compounds Are Potent Inducers of Adipogenesis in Vertebrates Tập 20 Số 9 - Trang 2141-2155 - 2006
Felix Grün, Hajime Watanabe, Zahra Zamanian, Lauren S. Maeda, Kayo Arima, Ryan Cubacha, David M. Gardiner, Jun Kanno, Taisen Iguchi, Bruce Blumberg
AbstractDietary and xenobiotic compounds can disrupt endocrine signaling,
particularly of steroid receptors and sexual differentiation. Evidence is also
mounting that implicates environmental agents in the growing epidemic of
obesity. Despite a long-standing interest in such compounds, their identity has
remained elusive. Here we show that the persistent and ubiquitous environmental
contaminant, t... hiện toàn bộ
Estrogen Receptor (ER)-β Reduces ERα-Regulated Gene Transcription, Supporting a “Ying Yang” Relationship between ERα and ERβ in Mice Tập 17 Số 2 - Trang 203-208 - 2003
Marie K. Lagerquist, Sofia Movérare, Stanko Skrtic, Hui Gao, Karin Dahlman‐Wright, Jan-Ακε Gustafsson, Claes Ohlsson
Abstract Estrogen is of importance for the regulation of adult bone metabolism.
The aim of the present study was to determine the role of estrogen receptor-β
(ERβ) in vivo on global estrogen-regulated transcriptional activity in bone. The
effect of estrogen in bone of ovariectomized mice was determined using
microarray analysis including 9400 genes. Most of the genes (95% = 240 genes)
that were in... hiện toàn bộ