The Endocrine Society

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αvβ3 Integrins and Pyk2 Mediate Insulin-Like Growth Factor I Activation of Src and Mitogen-Activated Protein Kinase in 3T3-L1 Cells
The Endocrine Society - Tập 19 Số 7 - Trang 1859-1867 - 2005
H Sekimoto, Jodi Eipper-Mains, Sunthorn Pond‐Tor, Charlotte M. Boney
AbstractIGF-I stimulates cell growth through interaction of the IGF receptor with multiprotein signaling complexes. However, the mechanisms of IGF-I receptor-mediated signaling are not completely understood. We have previously shown that IGF-I-stimulated 3T3-L1 cell proliferation is dependent on Src activation of the ERK-1/2 MAPK pathway. We hypothesized that IGF-I activation of the MAPK pathway i... hiện toàn bộ
Nonpituitary human prolactin gene transcription is independent of Pit-1 and differentially controlled in lymphocytes and in endometrial stroma
The Endocrine Society - Tập 8 Số 3 - Trang 356-373 - 1994
Birgit Gellersen
Characterization of an up-stream promoter directing extrapituitary expression of the human prolactin gene
The Endocrine Society - Tập 8 Số 5 - Trang 635-642 - 1994
M. Berwaer
Brain Somatostatin Receptors Are Up-Regulated In Somatostatin-Deficient Mice
The Endocrine Society - Tập 16 Số 8 - Trang 1951-1963 - 2002
José Luis Ramı́rez, Rania Mouchantaf, Ujendra Kumar, Veronica Otero Corchon, Marcelo Rubinstein, Malcolm J. Low, Yogesh Patel
Somatostatin Receptor Subtype 2 Knockout Mice Are Refractory to Growth Hormone-Negative Feedback on Arcuate Neurons
The Endocrine Society - Tập 11 Số 11 - Trang 1709-1717 - 1997
H. Zheng
In Vivo Induction of Glial Cell Proliferation and Axonal Outgrowth and Myelination by Brain-Derived Neurotrophic Factor
The Endocrine Society - Tập 20 Số 11 - Trang 2987-2998 - 2006
Dorien M. de Groot, Anton J. M. Coenen, A.A.J. Verhofstad, F. Van Herp, Gerard J. M. Martens
AbstractBrain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family of neuronal cell survival and differentiation factors but is thought to be involved in neuronal cell proliferation and myelination as well. To explore the role of BDNF in vivo, we employed the intermediate pituitary melanotrope cells of the amphibian Xenopus laevis as a model system. These cells mediate background ... hiện toàn bộ
11β-Hydroxysteroid Dehydrogenase Expression and Glucocorticoid Synthesis Are Directed by a Molecular Switch during Osteoblast Differentiation
The Endocrine Society - Tập 19 Số 3 - Trang 621-631 - 2005
Marco Eijken, Martin Hewison, Mark S. Cooper, Frank H. de Jong, Hideki Chiba, Paul M. Stewart, André G. Uitterlinden, Huibert A. P. Pols, Johannes P.T.M. van Leeuwen
Abstract11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) plays an important role in the prereceptor regulation of corticosteroids by locally converting cortisone into active cortisol. To investigate the impact of this mechanism on osteoblast development, we have characterized 11β-HSD1 activity and regulation in a differentiating human osteoblast cell line (SV-HFO). Continuous treatment with the ... hiện toàn bộ
The Human Glucocorticoid Receptor (hGR) β Isoform Suppresses the Transcriptional Activity of hGRα by Interfering with Formation of Active Coactivator Complexes
The Endocrine Society - Tập 19 Số 1 - Trang 52-64 - 2005
Evangelia Charmandari, George P. Chrousos, Takamasa Ichijo, Nisan Bhattacharyya, Alessandra Vottero, Emmanuil Souvatzoglou, Tomoshige Kino
Attenuation of Glucocorticoid Signaling through Targeted Degradation of p300 via the 26S Proteasome Pathway
The Endocrine Society - Tập 16 Số 12 - Trang 2819-2827 - 2002
Qiao Li, Anna Su, Jihong Chen, Yvonne A. Lefebvre, Robert J.G. Haché
AbstractThe effects of acetylation on gene expression are complex, with changes in chromatin accessibility intermingled with direct effects on transcriptional regulators. For the nuclear receptors, both positive and negative effects of acetylation on specific gene transcription have been observed. We report that p300 and steroid receptor coactivator 1 interact transiently with the glucocorticoid r... hiện toàn bộ
Codependence of Growth Hormone-Responsive, Sexually Dimorphic Hepatic Gene Expression on Signal Transducer and Activator of Transcription 5b and Hepatic Nuclear Factor 4α
The Endocrine Society - Tập 20 Số 3 - Trang 647-660 - 2006
Minita G. Holloway, Ekaterina V. Laz, David J. Waxman
AbstractTargeted disruption of the signal transducer and activator of transcription 5b gene (STAT5b) leads to decreased expression in male mouse liver of a male-predominant cytochrome (Cyp) 2d protein, whereas female-predominant Cyp2b proteins are increased. Presently, we characterize the effects of STAT5b deficiency on 15 specific, individual Cyp RNAs and other sexually dimorphic liver gene produ... hiện toàn bộ
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