11β-Hydroxysteroid Dehydrogenase Expression and Glucocorticoid Synthesis Are Directed by a Molecular Switch during Osteoblast DifferentiationThe Endocrine Society - Tập 19 Số 3 - Trang 621-631 - 2005
Marco Eijken, Martin Hewison, Mark S. Cooper, Frank H. de Jong, Hideki Chiba, Paul M. Stewart, André G. Uitterlinden, Huibert A. P. Pols, Johannes P.T.M. van Leeuwen
Abstract11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) plays an important role in the prereceptor regulation of corticosteroids by locally converting cortisone into active cortisol. To investigate the impact of this mechanism on osteoblast development, we have characterized 11β-HSD1 activity and regulation in a differentiating human osteoblast cell line (SV-HFO...... hiện toàn bộ
Subfertility with Defective Folliculogenesis in Female Mice Lacking Testicular Orphan Nuclear Receptor 4The Endocrine Society - Tập 22 Số 4 - Trang 858-867 - 2008
Lu-Min Chen, Ruey-Sheng Wang, Yi-Fen Lee, Ning-Chun Liu, Yu‐Jia Chang, Cheng‐Chia Wu, Shaozhen Xie, Yao‐Ching Hung, Chawnshang Chang
Testicular orphan nuclear receptor 4 (TR4) plays essential roles for normal spermatogenesis in male mice. However, its roles in female fertility and ovarian function remain largely unknown. Here we found female mice lacking TR4 (TR4−/−) displayed subfertility and irregular estrous cycles. TR4−/− female mice ovaries were smaller with fewer or no preovulatory follicles and corpora lutea. Aft...... hiện toàn bộ