Stem cells translational medicine

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Long-Term Results of Cultured Limbal Stem Cell Versus Limbal Tissue Transplantation in Stage III Limbal Deficiency
Stem cells translational medicine - Tập 8 Số 12 - Trang 1230-1241 - 2019
Vincent Borderie, Djida Ghoubay, Cristina Georgeon, Marie Borderie, Céline de Sousa, Anne Legendre, Hélène Rouard
Abstract We aimed to evaluate efficiency and safety of transplantation of limbal stem cells (LSC) cultured on human amniotic membrane with no feeders and to compare cultured LSC with limbal tissue transplantation. Thirty eyes with stage III LSC deficiency were treated with autologous (autoLSC) or allogeneic (alloLSC) cultured LSC transplantation (prospective phase II clinical trial; average follow... hiện toàn bộ
Three-Year Outcomes of Cultured Limbal Epithelial Allografts in Aniridia and Stevens-Johnson Syndrome Evaluated Using the Clinical Outcome Assessment in Surgical Trials Assessment Tool
Stem cells translational medicine - Tập 3 Số 2 - Trang 265-275 - 2014
Alex J. Shortt, Catey Bunce, Hannah J. Levis, Peter Blows, Caroline J Doré, Amanda Vernon, Genevieve A. Secker, Stephen J. Tuft, Julie T. Daniels
Abstract Limbal stem cell deficiency (LSCD) is an eye disorder in which the stem cells responsible for forming the surface skin of the cornea are destroyed by disease. This results in pain, loss of vision, and a cosmetically unpleasant appearance. Many new treatments, including stem cell therapies, are emerging for the treatment of this condition, but assessment of these new technologies is severe... hiện toàn bộ
Neurotrophin-3 contributes to benefits of human embryonic stem cell-derived cardiovascular progenitor cells against reperfused myocardial infarction
Stem cells translational medicine - Tập 10 Số 5 - Trang 756-772 - 2021
Wei Bi, Jinxi Wang, Yun Jiang, Qiang Li, Shihui Wang, Meilan Liu, Qiao Liu, Fang Li, Christian Paul, Yigang Wang, Huang‐Tian Yang
Abstract Acute myocardial infarction (MI) resulting from coronary ischemia is a major cause of disability and death worldwide. Transplantation of human embryonic stem cell (hESC)-derived cardiovascular progenitor cells (hCVPCs) promotes the healing of infarcted hearts by secreted factors. However, the hCVPC-secreted proteins contributing to cardiac repair remain largely unidentified. In this study... hiện toàn bộ
Perspective on human pluripotent stem cell-derived cardiomyocytes in heart disease modeling and repair
Stem cells translational medicine - Tập 9 Số 10 - Trang 1121-1128 - 2020
Qiang Li, Jia Wang, Qiang Wu, Nan Cao, Huang‐Tian Yang
Abstract Heart diseases (HDs) are the leading cause of morbidity and mortality worldwide. Despite remarkable clinical progress made, current therapies cannot restore the lost myocardium, and the correlation of genotype to phenotype of many HDs is poorly modeled. In the past two decades, with the rapid developments of human pluripotent stem cell (hPSC) biology and technology that allow the efficien... hiện toàn bộ
Oncolytic Herpes Simplex Virus Counteracts the Hypoxia-Induced Modulation of Glioblastoma Stem-Like Cells
Stem cells translational medicine - Tập 1 Số 4 - Trang 322-332 - 2012
Donatella Sgubin, Hiroaki Wakimoto, Ryuichi Kanai, Samuel D. Rabkin, Robert L. Martuza
Abstract Glioblastoma (GBM), a fatal malignant brain tumor, contains abundant hypoxic regions that provide a “niche” to promote both the maintenance and enrichment of glioblastoma stem-like cells (GSCs) and confer resistance to chemo- and radiotherapy. Since GSCs, with an ability to resist conventional therapies, may be responsible for tumor recurrence, targeting GSCs located in such a hypoxic env... hiện toàn bộ
Adipose Stromal Cells Repair Pressure Ulcers in Both Young and Elderly Mice: Potential Role of Adipogenesis in Skin Repair
Stem cells translational medicine - Tập 4 Số 6 - Trang 632-642 - 2015
Amy L. Strong, Annie C. Bowles, Connor P. MacCrimmon, Trivia Frazier, Stephen J. Lee, Xiying Wu, Adam J. Katz, Barbara Gawrońska‐Kozak, Bruce A. Bunnell, Jeffrey M. Gimble
Abstract More than 2.5 million patients in the U.S. require treatment for pressure ulcers annually, and the elderly are at particularly high risk for pressure ulcer development. Current therapy for pressure ulcers consists of conservative medical management for shallow lesions and aggressive debridement and surgery for deeper lesions. The current study uses a murine model to address the hypothesis... hiện toàn bộ
Concise Review: Musculoskeletal Stem Cells to Treat Age-Related Osteoporosis
Stem cells translational medicine - Tập 6 Số 10 - Trang 1930-1939 - 2017
Jeffrey Kiernan, John E. Davies, William L. Stanford
Abstract Age-related (type-II) osteoporosis is a common and debilitating condition driven in part by the loss of bone marrow (BM) mesenchymal stromal cells (MSC) and their osteoblast progeny, leading to reduced bone formation. Current pharmacological regiments targeting age-related osteoporosis do not directly treat the disease by increasing bone formation, but instead use bisphosphonates to reduc... hiện toàn bộ
Functional Plasticity of Adipose-Derived Stromal Cells During Development of Obesity
Stem cells translational medicine - Tập 5 Số 7 - Trang 893-900 - 2016
Xiang-Yang Zhu, Shuangtao Ma, Alfonso Eirin, John R. Woollard, LaTonya J. Hickson, Dong Sun, Amir Lerman, Lilach O. Lerman
Abstract Obesity is a major risk factor for a number of chronic diseases, including diabetes, cardiovascular diseases, and cancer. Expansion of the adipose mass requires adipocyte precursor cells that originate from multipotent adipose-derived stromal cells (ASCs), which in turn also participate in repair activities. ASC function might decline in a disease milieu, but it remains unclear whether AS... hiện toàn bộ
Placental Mesenchymal Stromal Cells Rescue Ambulation in Ovine Myelomeningocele
Stem cells translational medicine - Tập 4 Số 6 - Trang 659-669 - 2015
Aijun Wang, Erin G. Brown, Lee Lankford, B Keller, Christopher D. Pivetti, Nicole Sitkin, Michael S. Beattie, Jacqueline C. Bresnahan, Diana L. Farmer
Abstract Myelomeningocele (MMC)—commonly known as spina bifida—is a congenital birth defect that causes lifelong paralysis, incontinence, musculoskeletal deformities, and severe cognitive disabilities. The recent landmark Management of Myelomeningocele Study (MOMS) demonstrated for the first time in humans that in utero surgical repair of the MMC defect improves lower limb motor function, suggesti... hiện toàn bộ
Quản lý Môi trường Nước: Các Giải pháp Bền vững cho Tương lai Dịch bởi AI
Stem cells translational medicine - Tập 8 Số 5 - Trang 490-499 - 2019
Karīna Narbute, Vladimirs Piļipenko, Jolanta Pupure, Zane Dzirkale, Ugnė Jonavičė, Virginijus Tunaitis, Karolina Kriaučiūnaitė, Akvilė Jarmalavičiūtė, Baiba Jansone, Vija Kluša, Augustas Pivoriūnas
Tóm tắt Bệnh Parkinson (PD) là rối loạn thoái hóa thần kinh phổ biến thứ hai, ảnh hưởng đến hàng triệu người trên toàn thế giới. Hiện tại, không có phương pháp chữa trị hiệu quả cho PD; các phương pháp điều trị hiện có chỉ nhằm giải quyết triệu chứng mà không làm ngừng tiến triển của sự thoái hóa thần kinh. Các vesicle ngoại bào (EVs) có khả năng vượt qua hàng rào máu-não và thể hiện tiềm năng như... hiện toàn bộ
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