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Cơ quản chủ quản: BioMed Central Ltd. , BMC
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Developmental NeuroscienceCellular and Molecular NeuroscienceMedicine (miscellaneous)Neurology
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The hCMEC/D3 cell line as a model of the human blood brain barrier
Tập 10 Số 1 - 2013
Abstract Since the first attempts in the 1970s to isolate cerebral microvessel
endothelial cells (CECs) in order to model the blood–brain barrier (BBB) in
vitro, the need for a human BBB model that closely mimics the in vivo phenotype
and is reproducible and easy to grow, has been widely recognized by
cerebrovascular researchers in both academia and industry. While primary human
CECs would ideally...
A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity
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AbstractThe blood–brain barrier is playing a critical role in controlling the
influx and efflux of biological substances essential for the brain’s metabolic
activity as well as neuronal function. Thus, the functional and structural
integrity of the BBB is pivotal to maintain the homeostasis of the brain
microenvironment. The different cells and structures contributing to developing
this barrier ar...
The pulsating brain: A review of experimental and clinical studies of intracranial pulsatility
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Nonsurgical therapy for hydrocephalus: a comprehensive and critical review
Tập 13 - Trang 1-20 - 2016
Pharmacological interventions have been tested experimentally and clinically to
prevent hydrocephalus and avoid the need for shunting beginning in the 1950s.
Clinical trials of varied quality have not demonstrated lasting and convincing
protective effects through manipulation of cerebrospinal fluid production,
diuresis, blood clot fibrinolysis, or manipulation of fibrosis in the
subarachnoid compa...
Modeling the blood–brain barrier using stem cell sources
Tập 10 Số 1 - 2013
Abstract The blood–brain barrier (BBB) is a selective endothelial interface that
controls trafficking between the bloodstream and brain interstitial space.
During development, the BBB arises as a result of complex multicellular
interactions between immature endothelial cells and neural progenitors, neurons,
radial glia, and pericytes. As the brain develops, astrocytes and pericytes
further contrib...
Role of iPSC-derived pericytes on barrier function of iPSC-derived brain microvascular endothelial cells in 2D and 3D
Tập 16 Số 1 - 2019
Developmental changes in the transcriptome of the rat choroid plexus in relation to neuroprotection
- 2013
Abstract Background The choroid plexuses are the interface between the blood and
the cerebrospinal fluid (CSF) contained within the ventricular spaces of the
central nervous system. The tight junctions linking adjacent cells of the
choroidal epithelium create a physical barrier to paracellular movement of
molecules. Multispecific efflux transporters as well as drug-metabolizing and
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