Babette B. Weksler, Ignacio A. Romero, Pierre‐Olivier Couraud
AbstractSince the first attempts in the 1970s to isolate cerebral microvessel endothelial cells (CECs) in order to model the blood–brain barrier (BBB) in vitro, the need for a human BBB model that closely mimics the in vivo phenotype and is reproducible and easy to grow, has been widely recognized by ...... hiện toàn bộ
AbstractThe blood–brain barrier is playing a critical role in controlling the influx and efflux of biological substances essential for the brain’s metabolic activity as well as neuronal function. Thus, the functional and structural integrity of the BBB is pivotal to maintain the homeostasis of the brain microenvironment. The different cells and structures contribut...... hiện toàn bộ
Ethan S. Lippmann, Abraham Al‐Ahmad, Sean P. Palecek, Eric V. Shusta
AbstractThe blood–brain barrier (BBB) is a selective endothelial interface that controls trafficking between the bloodstream and brain interstitial space. During development, the BBB arises as a result of complex multicellular interactions between immature endothelial cells and neural progenitors, neurons, radial glia, and pericytes. As the brain develop...... hiện toàn bộ
Ingrid Kratzer, Shane A. Liddelow, NR Saunders, Katarzyna Dziegielewska, Nathalie Strazielle, Jean-François Ghersi-Egea
AbstractBackgroundThe choroid plexuses are the interface between the blood and the cerebrospinal fluid (CSF) contained within the ventricular spaces of the central nervous system. The tight junctions linking adjacent cells of the choroidal epithelium create a physical barrier to paracellular mo...... hiện toàn bộ