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Neurovascular unit disruption and blood–brain barrier leakage in MCT8 deficiency
Springer Science and Business Media LLC - Tập 20 - Trang 1-20 - 2023
Marina Guillén-Yunta, Víctor Valcárcel-Hernández, Ángel García-Aldea, Guadalupe Soria, José Manuel García-Verdugo, Ana Montero-Pedrazuela, Ana Guadaño-Ferraz
The monocarboxylate transporter 8 (MCT8) plays a vital role in maintaining brain thyroid hormone homeostasis. This transmembrane transporter is expressed at the brain barriers, as the blood–brain barrier (BBB), and in neural cells, being the sole known thyroid hormone-specific transporter to date. Inactivating mutations in the MCT8 gene (SLC16A2) cause the Allan-Herndon-Dudley Syndrome (AHDS) or M...... hiện toàn bộ
Normal pressure hydrocephalus – why treatment is often delayed or not even initiated
Springer Science and Business Media LLC - Tập 12 - Trang 1-2 - 2015
Uwe Kehler
Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle
Springer Science and Business Media LLC - Tập 8 - Trang 1-9 - 2011
Britta Engelhardt, Caroline Coisne
Neuronal activity within the central nervous system (CNS) strictly depends on homeostasis and therefore does not tolerate uncontrolled entry of blood components. It has been generally believed that under normal conditions, the endothelial blood-brain barrier (BBB) and the epithelial blood-cerebrospinal fluid barrier (BCSFB) prevent immune cell entry into the CNS. This view has recently changed whe...... hiện toàn bộ
Association between ventricular CSF biomarkers and outcome after shunt surgery in idiopathic normal pressure hydrocephalus
Springer Science and Business Media LLC - Tập 20 Số 1
Rebecca Grønning, Anna Jeppsson, Per Hellström, Katarina Laurell, Dan Farahmand, Henrik Zetterberg, Kaj Blennow, Carsten Wikkelsö, Mats Tullberg
Abstract Introduction The relationship between neurochemical changes and outcome after shunt surgery in idiopathic normal pressure hydrocephalus (iNPH), a treatable dementia and gait disorder, is unclear. We used baseline ventricular CSF to explore associations to outcome, after shunting, of biomark...... hiện toàn bộ
Characterization of choroid plexus in the preterm rabbit pup following subcutaneous administration of recombinant human IGF-1/IGFBP-3
Springer Science and Business Media LLC - Tập 20 - Trang 1-18 - 2023
Niklas Ortenlöf, Suvi Vallius, Helena Karlsson, Claes Ekström, Amanda Kristiansson, Bo Holmqvist, Olga Göransson, Magdaléna Vaváková, Martin Rydén, Galen Carey, Norman Barton, David Ley, Magnus Gram
Insulin-like growth factor-1 (IGF-1) is essential for normal brain development and regulates essential processes of vascular maturation and stabilization. Importantly, preterm birth is associated with reduced serum levels of IGF-1 as compared to in utero levels. Using a preterm rabbit pup model, we investigated the uptake of systemic recombinant human (rh) IGF-1 in complex with its main binding pr...... hiện toàn bộ
Preclinical update on regulation of intracranial pressure in relation to idiopathic intracranial hypertension
Springer Science and Business Media LLC - Tập 16 - Trang 1-12 - 2019
Sajedeh Eftekhari, Connar Stanley James Westgate, Maria Schmidt Uldall, Rigmor Hoejland Jensen
Elevated intracranial pressure (ICP) is observed in association with a range of brain disorders. One of these challenging disorders is idiopathic intracranial hypertension (IIH), characterized by raised ICP of unknown cause with significant morbidity and limited therapeutic options. In this review, special focus is put on the preclinical research performed in order to understand the pathophysiolog...... hiện toàn bộ
Developmental changes in the transcriptome of the rat choroid plexus in relation to neuroprotection
Springer Science and Business Media LLC - - 2013
Ingrid Kratzer, Shane A. Liddelow, NR Saunders, Katarzyna Dziegielewska, Nathalie Strazielle, Jean-François Ghersi-Egea
Abstract Background The choroid plexuses are the interface between the blood and the cerebrospinal fluid (CSF) contained within the ventricular spaces of the central nervous system. The tight junctions linking adjacent cells of the choroidal epithelium create a physical barrier to paracellular mo...... hiện toàn bộ
Hydraulic resistance of three-dimensional pial perivascular spaces in the brain
Springer Science and Business Media LLC - Tập 21 - Trang 1-18 - 2024
Kimberly A. S. Boster, Jiatong Sun, Jessica K. Shang, Douglas H. Kelley, John H. Thomas
Perivascular spaces (PVSs) carry cerebrospinal fluid (CSF) around the brain, facilitating healthy waste clearance. Measuring those flows in vivo is difficult, and often impossible, because PVSs are small, so accurate modeling is essential for understanding brain clearance. The most important parameter for modeling flow in a PVS is its hydraulic resistance, defined as the ratio of pressure drop to ...... hiện toàn bộ
Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasis
Springer Science and Business Media LLC - Tập 15 - Trang 1-10 - 2018
Edward G. Stopa, Keith Q. Tanis, Miles C. Miller, Elena V. Nikonova, Alexei A. Podtelezhnikov, Eva M. Finney, David J. Stone, Luiz M. Camargo, Lisan Parker, Ajay Verma, Andrew Baird, John E. Donahue, Tara Torabi, Brian P. Eliceiri, Gerald D. Silverberg, Conrad E. Johanson
In Alzheimer’s disease, there are striking changes in CSF composition that relate to altered choroid plexus (CP) function. Studying CP tissue gene expression at the blood–cerebrospinal fluid barrier could provide further insight into the epithelial and stromal responses to neurodegenerative disease states. Transcriptome-wide Affymetrix microarrays were used to determine disease-related changes in ...... hiện toàn bộ
Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells
Springer Science and Business Media LLC - Tập 20 - Trang 1-15 - 2023
Simone S. E. Nielsen, Mikkel R. Holst, Kristine Langthaler, Sarah Christine Christensen, Elisabeth Helena Bruun, Birger Brodin, Morten S. Nielsen
The detailed mechanisms by which the transferrin receptor (TfR) and associated ligands traffic across brain capillary endothelial cells (BECs) of the CNS-protective blood–brain barrier constitute an important knowledge gap within maintenance and regulation of brain iron homeostasis. This knowledge gap also presents a major obstacle in research aiming to develop strategies for efficient receptor-me...... hiện toàn bộ
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