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Neurovascular unit disruption and blood–brain barrier leakage in MCT8 deficiency
Springer Science and Business Media LLC - Tập 20 - Trang 1-20 - 2023
Marina Guillén-Yunta, Víctor Valcárcel-Hernández, Ángel García-Aldea, Guadalupe Soria, José Manuel García-Verdugo, Ana Montero-Pedrazuela, Ana Guadaño-Ferraz
The monocarboxylate transporter 8 (MCT8) plays a vital role in maintaining brain thyroid hormone homeostasis. This transmembrane transporter is expressed at the brain barriers, as the blood–brain barrier (BBB), and in neural cells, being the sole known thyroid hormone-specific transporter to date. Inactivating mutations in the MCT8 gene (SLC16A2) cause the Allan-Herndon-Dudley Syndrome (AHDS) or M... hiện toàn bộ
Normal pressure hydrocephalus – why treatment is often delayed or not even initiated
Springer Science and Business Media LLC - Tập 12 - Trang 1-2 - 2015
Uwe Kehler
Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle
Springer Science and Business Media LLC - Tập 8 - Trang 1-9 - 2011
Britta Engelhardt, Caroline Coisne
Neuronal activity within the central nervous system (CNS) strictly depends on homeostasis and therefore does not tolerate uncontrolled entry of blood components. It has been generally believed that under normal conditions, the endothelial blood-brain barrier (BBB) and the epithelial blood-cerebrospinal fluid barrier (BCSFB) prevent immune cell entry into the CNS. This view has recently changed whe... hiện toàn bộ
Integration of CSF pressure and flow data to further investigate nature of cerebrospinal compliance in hydrocephalus
Springer Science and Business Media LLC - Tập 12 Số Suppl 1 - Trang O66 - 2015
Simon Garnotel, Eric Schmidt, Zofi Czosnyka, Marc Baroncini, Gwenaël Pagé, Olivier Balédent
Shunt surgery in iNPH patients is cost-effective – a cost-utility analysis in the Western Sweden setting
Springer Science and Business Media LLC - Tập 12 - Trang 1-1 - 2015
Mats Tullberg, Jakob Petersen, Josefine Persson, Daniel Jaraj, Kerstin Andrén, Per Hellström, Carsten Wikkelsö, Åsa Lundgren-Nilsson
Association between ventricular CSF biomarkers and outcome after shunt surgery in idiopathic normal pressure hydrocephalus
Springer Science and Business Media LLC - Tập 20 Số 1
Rebecca Grønning, Anna Jeppsson, Per Hellström, Katarina Laurell, Dan Farahmand, Henrik Zetterberg, Kaj Blennow, Carsten Wikkelsö, Mats Tullberg
Abstract Introduction The relationship between neurochemical changes and outcome after shunt surgery in idiopathic normal pressure hydrocephalus (iNPH), a treatable dementia and gait disorder, is unclear. We used baseline ventricular CSF to explore associations to outcome, after shunting, of biomarkers selected to reflect a range of pathophysiological processes. Methods In 119 consecutive patients... hiện toàn bộ
Culture models to study leukocyte trafficking across the choroid plexus
Springer Science and Business Media LLC - Tập 10 - Trang 1-9 - 2013
Tobias Tenenbaum, Ulrike Steinmann, Corinna Friedrich, Jürgen Berger, Christian Schwerk, Horst Schroten
A critical point during the course of central nervous system infection is the influx of leukocytes from the blood into the brain across the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB). However, experimental in vitro models to investigate leukocyte transmigration across cultured choroid plexus epithelial cells have been lacking so far. We have developed a porcine and... hiện toàn bộ
The need for mathematical modelling of spatial drug distribution within the brain
Springer Science and Business Media LLC - - 2019
Esmée Vendel, Vivi Rottschäfer, Elizabeth C. M. de Lange
A comparison between the pathophysiology of multiple sclerosis and normal pressure hydrocephalus: is pulse wave encephalopathy a component of MS?
Springer Science and Business Media LLC - Tập 13 - Trang 1-12 - 2016
Grant A. Bateman, Jeannette Lechner-Scott, Rodney A. Lea
It has been suggested there is a chronic neurodegenerative disorder, underlying the pathophysiology of multiple sclerosis (MS), which is distinct from the more obvious immune-mediated attack on the white matter. Limited data exists indicating there is an alteration in pulse wave propagation within the craniospinal cavity in MS, similar to the findings in normal pressure hydrocephalus (NPH). It is ... hiện toàn bộ
Fluids and barriers of the CNS: a historical viewpoint
Springer Science and Business Media LLC - Tập 8 - Trang 1-17 - 2011
Shane A Liddelow
Tracing the exact origins of modern science can be a difficult but rewarding pursuit. It is possible for the astute reader to follow the background of any subject through the many important surviving texts from the classical and ancient world. While empirical investigations have been described by many since the time of Aristotle and scientific methods have been employed since the Middle Ages, the ... hiện toàn bộ
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