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Characterization of choroid plexus in the preterm rabbit pup following subcutaneous administration of recombinant human IGF-1/IGFBP-3
Springer Science and Business Media LLC - Tập 20 - Trang 1-18 - 2023
Niklas Ortenlöf, Suvi Vallius, Helena Karlsson, Claes Ekström, Amanda Kristiansson, Bo Holmqvist, Olga Göransson, Magdaléna Vaváková, Martin Rydén, Galen Carey, Norman Barton, David Ley, Magnus Gram
Insulin-like growth factor-1 (IGF-1) is essential for normal brain development and regulates essential processes of vascular maturation and stabilization. Importantly, preterm birth is associated with reduced serum levels of IGF-1 as compared to in utero levels. Using a preterm rabbit pup model, we investigated the uptake of systemic recombinant human (rh) IGF-1 in complex with its main binding pr...... hiện toàn bộ
Preclinical update on regulation of intracranial pressure in relation to idiopathic intracranial hypertension
Springer Science and Business Media LLC - Tập 16 - Trang 1-12 - 2019
Sajedeh Eftekhari, Connar Stanley James Westgate, Maria Schmidt Uldall, Rigmor Hoejland Jensen
Elevated intracranial pressure (ICP) is observed in association with a range of brain disorders. One of these challenging disorders is idiopathic intracranial hypertension (IIH), characterized by raised ICP of unknown cause with significant morbidity and limited therapeutic options. In this review, special focus is put on the preclinical research performed in order to understand the pathophysiolog...... hiện toàn bộ
Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasis
Springer Science and Business Media LLC - Tập 15 - Trang 1-10 - 2018
Edward G. Stopa, Keith Q. Tanis, Miles C. Miller, Elena V. Nikonova, Alexei A. Podtelezhnikov, Eva M. Finney, David J. Stone, Luiz M. Camargo, Lisan Parker, Ajay Verma, Andrew Baird, John E. Donahue, Tara Torabi, Brian P. Eliceiri, Gerald D. Silverberg, Conrad E. Johanson
In Alzheimer’s disease, there are striking changes in CSF composition that relate to altered choroid plexus (CP) function. Studying CP tissue gene expression at the blood–cerebrospinal fluid barrier could provide further insight into the epithelial and stromal responses to neurodegenerative disease states. Transcriptome-wide Affymetrix microarrays were used to determine disease-related changes in ...... hiện toàn bộ
Antibody indices of infectious pathogens from serum and cerebrospinal fluid in patients with schizophrenia spectrum disorders
Springer Science and Business Media LLC - Tập 19 - Trang 1-12 - 2022
Kimon Runge, Agnes Balla, Bernd L. Fiebich, Simon J. Maier, Benjamin Pankratz, Andrea Schlump, Kathrin Nickel, Rick Dersch, Katharina Domschke, Ludger Tebartz van Elst, Dominique Endres
Infectious and immunological theories of schizophrenia have been discussed for over a century. Contradictory results for infectious agents in association with schizophrenia spectrum disorders (SSDs) were reported. The rationale of this study was to investigate intrathecal antibody synthesis of the most frequently discussed neurotropic pathogens using a pathogen-specific antibody index (AI) in pati...... hiện toàn bộ
A new glaucoma hypothesis: a role of glymphatic system dysfunction
Springer Science and Business Media LLC - Tập 12 - Trang 1-6 - 2015
Peter Wostyn, Debby Van Dam, Kurt Audenaert, Hanspeter Esriel Killer, Peter Paul De Deyn, Veva De Groot
In a recent review article titled “A new look at cerebrospinal fluid circulation”, Brinker et al. comprehensively described novel insights from molecular and cellular biology as well as neuroimaging research, which indicate that cerebrospinal fluid (CSF) physiology is much more complex than previously believed. The glymphatic system is a recently defined brain-wide paravascular pathway for CSF and...... hiện toàn bộ
Repeated lumbar punctures within 3 days may affect CSF biomarker levels
Springer Science and Business Media LLC - Tập 16 Số 1 - 2019
Martin Olsson, Johan Ärlig, Jan Hedner, Kaj Blennow, Henrik Zetterberg
AbstractLumbar puncture (LP) is a common way of collecting cerebrospinal fluid (CSF) both in the clinic and in research. In this extension of a study on the relationship between sleep deprivation and CSF biomarkers for Alzheimer’s disease, we investigated CSF biomarker dynamics in relation to rebound sleep after sleep deprivation. Two LPs were performed within 3 da...... hiện toàn bộ
Development of a human in vitro blood–brain tumor barrier model of diffuse intrinsic pontine glioma to better understand the chemoresistance
Springer Science and Business Media LLC - Tập 17 - Trang 1-15 - 2020
Clémence Deligne, Johan Hachani, Sophie Duban-Deweer, Samuel Meignan, Pierre Leblond, Angel M. Carcaboso, Yasuteru Sano, Fumitaka Shimizu, Takashi Kanda, Fabien Gosselet, Marie-Pierre Dehouck, Caroline Mysiorek
Pediatric diffuse intrinsic pontine glioma (DIPG) represents one of the most devastating and lethal brain tumors in children with a median survival of 12 months. The high mortality rate can be explained by the ineligibility of patients to surgical resection due to the diffuse growth pattern and midline localization of the tumor. While the therapeutic strategies are unfortunately palliative, the bl...... hiện toàn bộ
Abstracts from the Virtual Symposium “Signal Transduction at the Blood–Brain Barriers”
Springer Science and Business Media LLC - Tập 18 - Trang 1-16 - 2021
Relationship between CSF dynamics and outcome after shunting in NPH- 20 years of single centre experience
Springer Science and Business Media LLC - Tập 12 - Trang 1-1 - 2015
Eva Nabbanja, Marek Czosnyka, Nicole Keong, Matthew Garnett, John D Pickard, Zofia Helena Czosnyka
Comparison of the sagittal sinus cross-sectional area between patients with multiple sclerosis, hydrocephalus, intracranial hypertension and spontaneous intracranial hypotension: a surrogate marker of venous transmural pressure?
Springer Science and Business Media LLC - - 2017
Grant A. Bateman, Jeannette Lechner‐Scott, Ross Copping, Christopher Moeskops, Swee Leong Yap
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