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A new look at cerebrospinal fluid movement
Springer Science and Business Media LLC - - 2014
Darko Orešković, Marijan Klarica
The quantitative motion analysis using portable gait rhythmogram after CSF drainage in the patients with idiopathic normal pressure hydrocephalus
Springer Science and Business Media LLC - - 2015
Makiko Yogo, Shusaku Omoto, Masayo Morita, Masahiko Suzuki
Imaging features associated with idiopathic normal pressure hydrocephalus have high specificity even when comparing with vascular dementia and atypical parkinsonism
Springer Science and Business Media LLC - Tập 18 - Trang 1-10 - 2021
David Fällmar, Oliver Andersson, Lena Kilander, Malin Löwenmark, Dag Nyholm, Johan Virhammar
Vascular dementia (VaD) and atypical parkinsonism often present with symptoms that can resemble idiopathic normal pressure hydrocephalus (iNPH) and enlarged cerebral ventricles, and can be challenging differential diagnoses. The aim was to investigate frequencies of imaging features usually associated with iNPH and their radiological diagnostic accuracy in a sample containing the relevant differen...... hiện toàn bộ
Sex-specific differences in organic anion transporting polypeptide 1a4 (Oatp1a4) functional expression at the blood–brain barrier in Sprague–Dawley rats
Springer Science and Business Media LLC - Tập 15 - Trang 1-12 - 2018
Hrvoje Brzica, Wazir Abdullahi, Bianca G. Reilly, Patrick T. Ronaldson
Targeting endogenous blood–brain barrier (BBB) transporters such as organic anion transporting polypeptide 1a4 (Oatp1a4) can facilitate drug delivery for treatment of neurological diseases. Advancement of Oatp targeting for optimization of CNS drug delivery requires characterization of sex-specific differences in BBB expression and/or activity of this transporter. In this study, we investigated se...... hiện toàn bộ
Transporter-mediated L-glutamate elimination from cerebrospinal fluid: possible involvement of excitatory amino acid transporters expressed in ependymal cells and choroid plexus epithelial cells
Springer Science and Business Media LLC - Tập 12 - Trang 1-11 - 2015
Shin-ichi Akanuma, Tatsuhiko Sakurai, Masanori Tachikawa, Yoshiyuki Kubo, Ken-ichi Hosoya
L-Glutamate (L-Glu) is the major excitatory neurotransmitter in the CNS, and its level in cerebrospinal fluid (CSF) is reported to be increased in neuroexcitatory diseases such as epilepsy. Since L-Glu concentration in the CSF is reported to be lower than that in plasma, it has been proposed that some mechanisms of L-Glu clearance from the CSF operate in the brain. The purpose of this study was to...... hiện toàn bộ
Direction and magnitude of cerebrospinal fluid flow vary substantially across central nervous system diseases
Springer Science and Business Media LLC - Tập 18 - Trang 1-18 - 2021
Per Kristian Eide, Lars Magnus Valnes, Erika Kristina Lindstrøm, Kent-Andre Mardal, Geir Ringstad
Several central nervous system diseases are associated with disturbed cerebrospinal fluid (CSF) flow patterns and have typically been characterized in vivo by phase-contrast magnetic resonance imaging (MRI). This technique is, however, limited by its applicability in space and time. Phase-contrast MRI has yet to be compared directly with CSF tracer enhanced imaging, which can be considered gold st...... hiện toàn bộ
A computerized neuropsychological test battery designed for idiopathic normal pressure hydrocephalus
Springer Science and Business Media LLC - Tập 11 - Trang 1-13 - 2014
Anders Behrens, Anders Eklund, Eva Elgh, Cynthia Smith, Michael A Williams, Jan Malm
A tool for standardized and repeated neuropsychological assessments in patients with idiopathic normal pressure hydrocephalus (INPH) is needed. The objective of this study was to develop a computerized neuropsychological test battery designed for INPH and to evaluate its reliability, validity and patient’s ability to complete the tests. Based on a structured review of the literature on neuropsycho...... hiện toàn bộ
Tachycardia and hypertension enhance tracer efflux from the spinal cord
Springer Science and Business Media LLC - Tập 18 - Trang 1-15 - 2021
Shinuo Liu, Lynne E. Bilston, Marcus A. Stoodley, Sarah J. Hemley
Disruption of cerebrospinal fluid (CSF)/interstitial fluid (ISF) exchange in the spinal cord is likely to contribute to central nervous system (CNS) diseases that involve abnormal fluid accumulation, including spinal cord oedema and syringomyelia. However, the physiological factors that govern fluid transport in the spinal cord are poorly understood. The aims of this study were to determine the ef...... hiện toàn bộ
Repeated lumbar punctures within 3 days may affect CSF biomarker levels
Springer Science and Business Media LLC - Tập 16 Số 1 - 2019
Martin Olsson, Johan Ärlig, Jan Hedner, Kaj Blennow, Henrik Zetterberg
AbstractLumbar puncture (LP) is a common way of collecting cerebrospinal fluid (CSF) both in the clinic and in research. In this extension of a study on the relationship between sleep deprivation and CSF biomarkers for Alzheimer’s disease, we investigated CSF biomarker dynamics in relation to rebound sleep after sleep deprivation. Two LPs were performed within 3 da...... hiện toàn bộ
Are CSF CXCL13 concentrations solely dependent on intrathecal production? A commentary on “Chemokine CXCL13 in serum, CSF, and blood–CSF barrier function”
Springer Science and Business Media LLC - Tập 18 - Trang 1-4 - 2021
Krista D. DiSano, Francesca Gilli, Andrew R. Pachner
Pilz et al. (Fluids Barriers CNS 17:7; 2020) investigated how CSF CXCL13 concentrations are influenced by CXCL13 serum concentrations and blood-CSF barrier (BCSFB) function, comparing the impact of serum CXCL13 levels and Qalbumin (CSF albumin/serum albumin) on CSF CXCL13 among patients with CNS inflammation categorized as CXCL13 negative, low, medium, or high. Among all CXCL13 groups, their resul...... hiện toàn bộ
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