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Discovery and SAR exploration of N-aryl-N-(3-aryl-1,2,4-oxadiazol-5-yl)amines as potential therapeutic agents for prostate cancer
Springer Science and Business Media LLC - Tập 4 - Trang 1-5 - 2010
A new chemical series of antiproliferative compounds was identified via
high-throughput screening on DU-145 human prostate carcinoma cell line (hit
compound potency - 5.7 μM). Exploration of the two peripheral diversity vectors
of the hit molecule in a hit-targeted library and testing of the resulting
compounds led to SAR generalizations and identification of the 'best'
pharmacophoric moieties. Th...
Multi-analyte approach for determining the extraction of tobacco constituents from pouched snus by consumers during use
Springer Science and Business Media LLC - Tập 7 Số 1 - 2013
Abstract Background Snus is a smokeless oral tobacco product with a significant
history of use in Sweden, where it is regulated under food legislation. Users
place a small porous sachet or a pinch of loose snus between the upper jaw and
cheek for approximately one hour, leading to partial intake of tobacco
constituents. To understand user exposure to tobacco, a multi-analyte approach
based on the ...
GC-MS studies of the chemical composition of two inedible mushrooms of the genus Agaricus
Springer Science and Business Media LLC - Tập 1 - Trang 1-5 - 2007
Mushrooms in the genus Agaricus have worldwide distribution and include the
economically important species A. bisporus. Some Agaricus species are inedible,
including A. placomyces and A. pseudopratensis, which are similar in appearance
to certain edible species, yet are known to possess unpleasant odours and induce
gastrointestinal problems if consumed. We have studied the chemical composition
of ...
Microwave synthesis and thermal properties of polyacrylate derivatives containing itaconic anhydride moieties
Springer Science and Business Media LLC - Tập 6 - Trang 1-11 - 2012
Microwave irradiation as an alternative heat source is now a well-known method
in synthetic chemistry. Microwave heating has emerged as a powerful technique to
promote a variety of chemical reactions, offering reduced pollution, low cost
and offer high yields together with simplicity in processing and handling. On
the other hand, copolymers containing both hydrophilic and hydrophobic segments
are ...
Simple and green technique for sequestration and concentration of silver nanoparticles by polysaccharides immobilized on glass beads in aqueous media
Springer Science and Business Media LLC - Tập 9 Số 1 - 2015
Abstract Background Engineered nanoparticles have unique properties compared to
bulk materials and their commercial uses growing rapidly. They represent a
potential risk for environment and health and could be eventually released in
water. Silver nanoparticles (Ag NP) are applied in various products and are
well-known for their antibacterial properties. Nowadays, pre-concentration and
separation m...
Preparation and application of melamine cross-linked poly ammonium as shale inhibitor
Springer Science and Business Media LLC - - 2018
Bioaccumulative and conchological assessment of heavy metal transfer in a soil-plant-snail food chain
Springer Science and Business Media LLC - - 2012
Abstract Background Copper (Cu), zinc (Zn), cadmium (Cd), and lead (Pb) can pose
serious threats to environmental health because they tend to bioaccumulate in
terrestrial ecosystems. We investigated under field conditions the transfer of
these heavy metals in a soil-plant-snail food chain in Banat area, Romania. The
main goal of this paper was to assess the Roman snail (Helix pomatia) usefulness
i...
General peroxidase activity of a parallel G-quadruplex-hemin DNAzyme formed by Pu39WT - a mixed G-quadruplex forming sequence in the Bcl-2 P1 promoter
Springer Science and Business Media LLC - Tập 8 - Trang 1-7 - 2014
A 39-base-pair sequence (Pu39WT) located 58 to 19 base pairs upstream of the
Bcl-2 P1 promoter has been implicated in the formation of an intramolecular
mixed G-quadruplex structure and is believed to play a major role in the
regulation of bcl-2 transcription. However, an extensive functional exploration
requires further investigation. To further exploit the structure–function
relationship of the ...
Characterization of in vivo metabolites in rat urine following an oral dose of masitinib by liquid chromatography tandem mass spectrometry
Springer Science and Business Media LLC - Tập 12 - Trang 1-18 - 2018
Masitinib (MST) is an orally administered drug that targets mast cells and
macrophages, important cells for immunity, by inhibiting a limited number of
tyrosine kinases. It is currently registered in Europe and USA for the treatment
of mast cell tumors in dogs. AB Science announced that the European Medicines
Agency has accepted a conditional marketing authorization application for MST to
treat am...
Efficient 3D pharmacophore alignment as a tool for structure-based modeling and scoring
Springer Science and Business Media LLC - Tập 2 - Trang 1-1 - 2008
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