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Discovery and SAR exploration of N-aryl-N-(3-aryl-1,2,4-oxadiazol-5-yl)amines as potential therapeutic agents for prostate cancer
Springer Science and Business Media LLC - Tập 4 - Trang 1-5 - 2010
Mikhail Krasavin, Konstantin A Rufanov, Andrey V Sosnov, Ruben Karapetian, Elena Godovykh, Olga Soldatkina, Yan Lavrovsky, Andrei A Gakh
A new chemical series of antiproliferative compounds was identified via high-throughput screening on DU-145 human prostate carcinoma cell line (hit compound potency - 5.7 μM). Exploration of the two peripheral diversity vectors of the hit molecule in a hit-targeted library and testing of the resulting compounds led to SAR generalizations and identification of the 'best' pharmacophoric moieties. Th...... hiện toàn bộ
Multi-analyte approach for determining the extraction of tobacco constituents from pouched snus by consumers during use
Springer Science and Business Media LLC - Tập 7 Số 1 - 2013
Helena Digard, Nathan Gale, Graham Errington, Nicola Peters, Kevin McAdam
Abstract Background Snus is a smokeless oral tobacco product with a significant history of use in Sweden, where it is regulated under food legislation. Users place a small porous sachet or a pinch of loose snus between the upper jaw and cheek for approximately one hour, leading to partial intake ...... hiện toàn bộ
GC-MS studies of the chemical composition of two inedible mushrooms of the genus Agaricus
Springer Science and Business Media LLC - Tập 1 - Trang 1-5 - 2007
Assya Petrova, Kalina Alipieva, Emanuela Kostadinova, Daniela Antonova, Maria Lacheva, Melania Gjosheva, Simeon Popov, Vassya Bankova
Mushrooms in the genus Agaricus have worldwide distribution and include the economically important species A. bisporus. Some Agaricus species are inedible, including A. placomyces and A. pseudopratensis, which are similar in appearance to certain edible species, yet are known to possess unpleasant odours and induce gastrointestinal problems if consumed. We have studied the chemical composition of ...... hiện toàn bộ
Microwave synthesis and thermal properties of polyacrylate derivatives containing itaconic anhydride moieties
Springer Science and Business Media LLC - Tập 6 - Trang 1-11 - 2012
Sameh M Osman, Mohamed H El-Newehy, Salem S Al-Deyab, Ayman El-Faham
Microwave irradiation as an alternative heat source is now a well-known method in synthetic chemistry. Microwave heating has emerged as a powerful technique to promote a variety of chemical reactions, offering reduced pollution, low cost and offer high yields together with simplicity in processing and handling. On the other hand, copolymers containing both hydrophilic and hydrophobic segments are ...... hiện toàn bộ
Simple and green technique for sequestration and concentration of silver nanoparticles by polysaccharides immobilized on glass beads in aqueous media
Springer Science and Business Media LLC - Tập 9 Số 1 - 2015
Alaeddine Kibeche, Alexandre Dionne, Roxanne Brion-Roby, Christian Gagnon, Jonathan Gagnon
Abstract Background Engineered nanoparticles have unique properties compared to bulk materials and their commercial uses growing rapidly. They represent a potential risk for environment and health and could be eventually released in water. Silver nanoparticles (Ag NP) are applied in various produ...... hiện toàn bộ
Preparation and application of melamine cross-linked poly ammonium as shale inhibitor
Springer Science and Business Media LLC - - 2018
Li Zhang, Tiehu Li, Huang Lei, Zhengqin Ye, Zhongbin Ye, Yan Xiao, Lili Li, Qiang Deng, Gang Chen, Jie Zhang, Zhifang Zhang
Bioaccumulative and conchological assessment of heavy metal transfer in a soil-plant-snail food chain
Springer Science and Business Media LLC - - 2012
Dragoş Nica, Marian Bura, I. Gergen, Monica Hărmănescu, Despina-Maria Bordean
Abstract Background Copper (Cu), zinc (Zn), cadmium (Cd), and lead (Pb) can pose serious threats to environmental health because they tend to bioaccumulate in terrestrial ecosystems. We investigated under field conditions the transfer of these heavy metals in a soil-plant-snail food chain in Bana...... hiện toàn bộ
General peroxidase activity of a parallel G-quadruplex-hemin DNAzyme formed by Pu39WT - a mixed G-quadruplex forming sequence in the Bcl-2 P1 promoter
Springer Science and Business Media LLC - Tập 8 - Trang 1-7 - 2014
Bo Liu, Da Li, Hong Shang
A 39-base-pair sequence (Pu39WT) located 58 to 19 base pairs upstream of the Bcl-2 P1 promoter has been implicated in the formation of an intramolecular mixed G-quadruplex structure and is believed to play a major role in the regulation of bcl-2 transcription. However, an extensive functional exploration requires further investigation. To further exploit the structure–function relationship of the ...... hiện toàn bộ
Characterization of in vivo metabolites in rat urine following an oral dose of masitinib by liquid chromatography tandem mass spectrometry
Springer Science and Business Media LLC - Tập 12 - Trang 1-18 - 2018
Adnan A. Kadi, Sawsan M. Amer, Hany W. Darwish, Mohamed W. Attwa
Masitinib (MST) is an orally administered drug that targets mast cells and macrophages, important cells for immunity, by inhibiting a limited number of tyrosine kinases. It is currently registered in Europe and USA for the treatment of mast cell tumors in dogs. AB Science announced that the European Medicines Agency has accepted a conditional marketing authorization application for MST to treat am...... hiện toàn bộ
Efficient 3D pharmacophore alignment as a tool for structure-based modeling and scoring
Springer Science and Business Media LLC - Tập 2 - Trang 1-1 - 2008
Gerhard Wolber
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