Synthesis and biological profile of substituted benzimidazoles

Springer Science and Business Media LLC - Tập 12 - Trang 1-12 - 2018
Neelam Vashist1, Surinder Singh Sambi2, Balasubramanian Narasimhan3, Sanjiv Kumar3, Siong Meng Lim4,5, Syed Adnan Ali Shah4,6, Kalavathy Ramasamy4,5, Vasudevan Mani7
1SGT College of Pharmacy, Shree Guru Gobind Singh Tricentenary (SGT) University, Gurugram, India
2University School of Chemical Technology, Guru Gobind Singh Indraprastha University, Dwarka, India
3Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India
4Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Bandar Puncak Alam, Malaysia
5Collaborative Drug Discovery Research (CDDR) Group, Pharmaceutical Life Sciences Community of Research, Universiti Teknologi MARA (UiTM), Shah Alam, Malaysia
6Atta-ur-Rahman Institute for Natural Products Discovery (AuRIns), Universiti Teknologi MARA, Bandar Puncak Alam, Malaysia
7Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraidah, Kingdom of Saudi Arabia

Tóm tắt

A series of benzimidazole derivatives was developed and its chemical scaffolds were authenticated by NMR, IR, elemental analyses and physicochemical properties. The synthesized compounds were screened for their antimicrobial and antiproliferative activities. The synthesized benzimidazole compounds were evaluated for their antimicrobial activity using the tube dilution method and were found to exhibit good antimicrobial potential against selected Gram negative and positive bacterial and fungal species. The compounds were also assessed for their anticancer activity exhibited using the SRB assay and were found to elicit antiproliferative activity against MCF7 breast cancer cell line, which was comparable to the standard drug. Antimicrobial screening results indicated that compounds 1, 2 and 19 to be promising antimicrobial agents against selected microbial species and comparable to standard drugs which included norfloxacin and fluconazole. The anticancer screening results revealed that compounds, 12, 21, 22 and 29 to show the highest activity against MCF7 and their IC50 values were more potent than 5-fluorouracil.

Tài liệu tham khảo

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