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Springer Science and Business Media LLC

  0724-8741

 

 

Cơ quản chủ quản:  Springer New York , SPRINGER/PLENUM PUBLISHERS

Lĩnh vực:
Organic ChemistryBiotechnologyMolecular MedicinePharmacologyPharmacology (medical)Pharmaceutical Science

Các bài báo tiêu biểu

Critical Evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the Measurement of Nanoparticles and Protein Aggregates
Tập 27 Số 5 - Trang 796-810 - 2010
Vasco Filipe, Andrea Hawe, Wim Jiskoot
Physicochemical Parameters Associated with Nanoparticle Formation in the Salting-Out, Emulsification-Diffusion, and Nanoprecipitation Methods
- 2004
Sergio Galindo-Rodriguez, Eric Allémann, Hatem Fessi, Eric Doelker
Purpose. The aim of this work was to relate the physicochemical properties of the aqueous and organic phases used for nanoparticle (NP) preparation to the formation of NP produced by salting-out, emulsification-diffusion, and nanoprecipitation. Methods. Methacrylic acid copolymer and poly(vinyl alcohol) (PVAL) were selected as NP polymer and emulsifying agent, respectively. Salting-out and emulsification-diffusion NP batches were prepared modifying the PVAL content in the aqueous phase. For nanoprecipitation, NP were produced with variation of the polymer content and type of solvent in the organic phase. Results. For salting-out and emulsification-diffusion, NP formation was discussed in terms of the emulsification theory. The nanoemulsion obtained during NP preparation was visualized by scanning electron microscopy. Aqueous and organic phases used for NP preparation were characterized by their viscosity and surface tension. NP characteristics such as particle mean size, residual surfactant, suspendability in water after freeze-drying, and morphology were explained in terms of these properties. For nanoprecipitation, NP formation was analyzed considering the diffusion-stranding phenomenon. Conclusions. NP formation by salting-out and emulsification-diffusion was related to PVAL chain interactions at the droplet interface (e.g., reduction in the interfacial tension, mechanical sta- bilization, and steric stabilization) and in the bulk solution (hy- drodynamic stabilization). For nanoprecipitation, χsolvent-water and Δδsolvent-water of the organic phase solvents were well related to the NP characteristics.
Uptake and Cytotoxicity of Chitosan Molecules and Nanoparticles: Effects of Molecular Weight and Degree of Deacetylation
Tập 21 Số 2 - Trang 344-353 - 2004
Min Huang, Eugene Khor, Lee Yong Lim
Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio
Tập 32 Số 6 - Trang 2003-2014 - 2015
Tianzhi Yang, Paige Martin, Brittany Fogarty, Alison Brown, Kayla Schurman, Roger J. Phipps, Viravuth P. Yin, Paul R. Lockman, Shuhua Bai
Click Chemistry, A Powerful Tool for Pharmaceutical Sciences
Tập 25 Số 10 - Trang 2216-2230 - 2008
Christopher D. Hein, Xin-Ming Liu, Dong Wang
Dissolution Media Simulating Conditions in the Proximal Human Gastrointestinal Tract: An Update
Tập 25 Số 7 - Trang 1663-1676 - 2008
Ekarat Jantratid, Niels Janssen, Christos Reppas, Jennifer B. Dressman
An Overview of Tubulin Inhibitors That Interact with the Colchicine Binding Site
Tập 29 Số 11 - Trang 2943-2971 - 2012
Yan Lü, Jianjun Chen, Min Xiao, Wěi Li, Duane D. Miller
Apigenin: A Promising Molecule for Cancer Prevention
- 2010
Sanjeev Shukla, Sanjay Gupta
Recommendations for the Bioanalytical Method Validation of Ligand-Binding Assays to Support Pharmacokinetic Assessments of Macromolecules
- 2003
Binodh DeSilva, Wendell C. Smith, Russell Weiner, Marian Kelley, JoMarie Smolec, Ben Liu, Masood Khan, Richard Tacey, Howard Hill, Abbie Celniker
Characterization of the Human Upper Gastrointestinal Contents Under Conditions Simulating Bioavailability/Bioequivalence Studies
- 2006
Lida Kalantzi, Konstantinos Goumas, V. Kalioras, Bertil Abrahamsson, Jennifer B. Dressman, Christos Reppas