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Excipient Interaction with Cetylpyridinium Chloride Activity in Tablet Based Lozenges
Springer Science and Business Media LLC - - 1996
R. Michael E. Richards, James Z. Xing, Kirsty M. B. Mackay
Purpose. The purpose of the investigation was to determine the effect of tablet excipients on the activity of cetylpyridinium chloride (CPC) and the relative interaction between excipients and CPC. Methods. An analytical assay was developed to evaluate the interaction between CPC and the excipients. In vivo activity was investigated using six volunteers by determining the reduction in colony for...... hiện toàn bộ
New Safe Method for Preparation of Sarin-Exposed Human Erythrocytes Acetylcholinesterase Using Non-Toxic and Stable Sarin Analogue Isopropyl p-Nitrophenyl Methylphosphonate and its Application to Evaluation of Nerve Agent Antidotes
Springer Science and Business Media LLC - Tập 23 - Trang 2827-2833 - 2006
Hikoto Ohta, Takeshi Ohmori, Shinichi Suzuki, Hiroshi Ikegaya, Koichi Sakurada, Takehiko Takatori
A non-toxic and stable sarin analogue, isopropyl p-nitrophenyl methylphosphonate (INMP), was synthesized for safe preparation of sarin-exposed acetylcholinesterase (AChE). This agent was stable for years, able to be handled in an ordinary laboratory without special care, and its 50% inhibitory concentration (IC50) on 0.04 U/ml human erythrocytes AChE was 15 nM. This reagent was thought to be espec...... hiện toàn bộ
BOOK REVIEWS
Springer Science and Business Media LLC - Tập 7 - Trang 1330-1331 - 1990
Enhancing the Cellular Production of Extracellular Vesicles for Developing Therapeutic Applications
Springer Science and Business Media LLC - Tập 40 - Trang 833-853 - 2022
Nina Erwin, Maria Fernanda Serafim, Mei He
Extracellular vesicles (EVs) have various advantageous properties, including a small size, high biocompatibility, efficient cargo loading, and precise cell targeting ability, making them promising tools for therapeutic development. EVs have been increasingly explored for applications like drug delivery. However, due to limited cellular secretion rates of EVs, wide-scale clinical applications are n...... hiện toàn bộ
The Role of Metabolites in Bioequivalence
Springer Science and Business Media LLC - Tập 21 - Trang 1331-1344 - 2004
Kamal K. Midha, Maureen J. Rawson, John W. Hubbard
The role of metabolites in bioequivalence studies has been a contentious issue for many years. Many papers have published recommendations for the use of metabolite data based on anecdotal evidence from the results of bioequivalence studies. Such anecdotal evidence has validity, but the arguments lack weight because the “correct” answers are always unknown. A more promising area of exploration is r...... hiện toàn bộ
MicroRNA-302 Replacement Therapy Sensitizes Breast Cancer Cells to Ionizing Radiation
Springer Science and Business Media LLC - Tập 30 - Trang 1008-1016 - 2012
Zhongxing Liang, Jeffrey Ahn, Donna Guo, John R. Votaw, Hyunsuk Shim
Solid tumors can be resistant or develop resistance to radiotherapy. The purpose of this study is to explore whether microRNA-302 is involved in radioresistance and can be exploited as a sensitizer to enhance sensitivity of breast cancer cells to radiation therapy. MiR-302 expression levels in radioresistant cell lines were analyzed in comparison with their parent cell lines. Furthermore, we inves...... hiện toàn bộ
In Vitro, Ex Vivo and In Silico Mechanistic Elucidation of the Performance of an Optimized Porosity-Controlled Multi-Elemental Transbuccal System
Springer Science and Business Media LLC - Tập 32 - Trang 2384-2409 - 2015
Oluwatoyin A. Adeleke, Yahya E. Choonara, Lisa C. du Toit, Pradeep Kumar, Viness Pillay
To elucidate the mechanisms of construction and performance of a porosity controlled, multi-elemental transbuccal system employing experimental and computational approaches. The production of the formulation was guided through a Box-Benkhen design employing homogenization coupled with lyophilization. The physicochemical and physicomechanical properties of the experimental design formulations were ...... hiện toàn bộ
The Use of Microcalorimetry to Measure Thermodynamic Parameters of the Binding of Ligands to Insulin
Springer Science and Business Media LLC - Tập 7 - Trang 606-611 - 1990
Scott E. McGraw, Siegfried Lindenbaum
Flow microcalorimetry was used to measure the free energies, enthalpies, and entropies of interactions between the hormone insulin and small ligand molecules or ions. Measurable amounts of heat were obtained for binding of four phenolic preservative molecules—phenol, meta-cresol, resorcinol, and methylparaben—to both two-zinc and zinc-free insulin and for binding of zinc ions to zinc-free insulin....... hiện toàn bộ
RETRACTED ARTICLE: Inhibition of Tumor Angiogenesis by Tumstatin: Insights into Signaling Mechanisms and Implications in Cancer Regression
Springer Science and Business Media LLC - Tập 25 - Trang 2731-2739 - 2008
Akulapalli Sudhakar, Chandra S. Boosani
Growing tumors develop additional new blood vessels to meet the demand for adequate nutrients and oxygen, a process called angiogenesis. Cancer is a highly complex disease promoted by excess angiogenesis; interfering with this process poses for an attractive approach for controlling tumor growth. This hypothesis led to the identification of endogenous angiogenesis inhibitors generated from type IV...... hiện toàn bộ
A Cell Fractionation Approach for the Quantitative Analysis of Subcellular Drug Disposition
Springer Science and Business Media LLC - Tập 21 Số 1 - Trang 26-32 - 2004
Muralikrishna Duvvuri, Wenhong Feng, Amanda Mathis, Jeffrey P. Krise
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