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A Novel Hepatic-Targeting System for Therapeutic Cytokines That Delivers to the Hepatic Asialoglycoprotein Receptor, but Avoids Receptor-Mediated Endocytosis
Springer Science and Business Media LLC - Tập 19 - Trang 1736-1744 - 2002
Haruya Sato, Yukio Kato, Eiko Hayashi, Tomoyuki Tabata, Manabu Suzuki, Yoshiyuki Takahara, Yuichi Sugiyama
Purpose. To demonstrate the utilities of a synthetic low-affinity ligand ((Gal)3) for the asialoglycoprotein receptor (ASGP-R) as a hepatic targeting device for therapeutic cytokines. Methods. The site-specific incorporation of (Gal)3 or a typical high-affinity ligand (GalNAc)3 into IL-2 was catalyzed by microbial transglutaminase. The anti-tumor activities, pharmacokinetic profiles and receptor...... hiện toàn bộ
Drug Delivery Nanoparticles with Locally Tunable Toxicity Made Entirely from a Light-Activatable Prodrug of Doxorubicin
Springer Science and Business Media LLC - - 2017
Carolyn E. Schutt, Eran Zahavy, Santosh Aryal, Stacey Kuo, Selin Esener, Michael W. Berns, Sadik C. Esener
AAPS Electronic Scientist
Springer Science and Business Media LLC - Tập 18 Số 12 - Trang 1808-1809 - 2001
Machine Learning Attempts for Predicting Human Subcutaneous Bioavailability of Monoclonal Antibodies
Springer Science and Business Media LLC - - 2021
Hao Lou, Michael J. Hageman
Inhalation Delivery and Anti-tumor Activity of Celecoxib in Human Orthotopic Non-Small Cell Lung Cancer Xenograft Model
Springer Science and Business Media LLC - Tập 23 - Trang 2094-2106 - 2006
Suniket V. Fulzele, Abhijit Chatterjee, Madhu Sudhan Shaik, Tanise Jackson, Mandip Singh
To determine the in vivo anti-tumor effect of aerosolized Celecoxib (Cxb) in combination with i.v Docetaxel (Doc) and compare the anti-tumor effect with oral Cxb combined with i.v Doc in human orthotopic non-small cell lung cancer (NSCLC) xenograft model. Female Nu/Nu mice were implanted with orthotopic tumors by injecting A549 cells into the lung parenchyma. Seven day after tumor implantation the...... hiện toàn bộ
Why Have Clinical Trials of Antioxidants to Prevent Neurodegeneration Failed? - A Cellular Investigation of Novel Phenothiazine-Type Antioxidants Reveals Competing Objectives for Pharmaceutical Neuroprotection
Springer Science and Business Media LLC - - 2017
Maike J. Ohlow, Selina Sohre, Matthias Granold, Mathias Schreckenberger, Bernd Moosmann
Agarose Surface Coating Influences Intracellular Accumulation and Enhances Payload Stability of a Nano-delivery System
Springer Science and Business Media LLC - Tập 28 - Trang 1520-1530 - 2011
Enrica De Rosa, Ciro Chiappini, Dongmei Fan, Xuewu Liu, Mauro Ferrari, Ennio Tasciotti
Protein therapeutics often require repeated administrations of drug over a long period of time. Protein instability is a major obstacle to the development of systems for their controlled and sustained release. We describe a surface modification of nanoporous silicon particles (NSP) with an agarose hydrogel matrix that enhances their ability to load and release proteins, influencing intracellular d...... hiện toàn bộ
Potential Role of P-Glycoprotein in Affecting Hepatic Metabolism of Drugs
Springer Science and Business Media LLC - Tập 17 - Trang 903-905 - 2000
Win L. Chiou, Sang M. Chung, Ta C. Wu
Pharmacokinetics of Platinum in Cancer Patients Treated with Carboplatin in Combination with High-Dose Methotrexate
Springer Science and Business Media LLC - Tập 6 - Trang 492-496 - 1989
Adnan El-Yazigi, Magid Amer, Cazemiro R. Martin
The pharmacokinetics of platinum was investigated in 10 cancer patients treated with a 1-hr infusion of 300 mg/m2 of carboplatin which was given 2–4 days after the administration of 100 mg/kg (20-mg/kg bolus and 80-mg/kg intravenous infusion) of methotrexate. Platinum was analyzed in the samples by flameless atomic absorption spectrophotometry. The concentration vs time data for total platinum in ...... hiện toàn bộ
Preparation and Evaluation of a Xanthan Gum–Containing Linezolid Ophthalmic Solution for Topical Treatment of Experimental Bacterial Keratitis
Springer Science and Business Media LLC - Tập 38 - Trang 347-359 - 2021
Fan Zhang, Dongmei Jia, Qiqi Li, Mengmeng Zhang, Hongyun Liu, Xianggen Wu
To formulate a xanthan gum–containing linezolid ophthalmic solution (LZD-XG) as a new antibiotic treatment against ocular bacterial infection. LZD-XG was prepared and evaluated for its in vitro/in vivo ocular tolerance, in vitro/in vivo antibacterial activity, and in vivo ocular penetration. The optimized LZD-XG exhibited good in vitro/in vivo eye tolerance. A prolonged ocular surface residence ti...... hiện toàn bộ
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