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Controlled Gastric Emptying. II. In Vitro Erosion and Gastric Residence Times of an Erodible Device in Beagle Dogs
Springer Science and Business Media LLC - Tập 6 - Trang 506-509 - 1989
Robyn Cargill, Karen Engle, Colin R. Gardner, Patricia Porter, Randall V. Sparer, Joseph A. Fix
An erodible gastric retention device fabricated from various polymeric blends was examined in vitro for its dissolution properties and in vivo in fasting dogs for assessment of its gastric retention potential. Dissolution studies were conducted with extruded rods of polymer blends to assess their potential as candidates for the erodible component of a gastrically retained device. Based on results ...... hiện toàn bộ
Excipient Interaction with Cetylpyridinium Chloride Activity in Tablet Based Lozenges
Springer Science and Business Media LLC - - 1996
R. Michael E. Richards, James Z. Xing, Kirsty M. B. Mackay
Purpose. The purpose of the investigation was to determine the effect of tablet excipients on the activity of cetylpyridinium chloride (CPC) and the relative interaction between excipients and CPC. Methods. An analytical assay was developed to evaluate the interaction between CPC and the excipients. In vivo activity was investigated using six volunteers by determining the reduction in colony for...... hiện toàn bộ
Determination of Solute–Polymer Interaction Properties via Two-Stage Extraction
Springer Science and Business Media LLC - Tập 11 - Trang 774-775 - 1994
Dennis R. Jenke
Diffusion of lonizable Solutes Across Planar Lipid Bilayer Membranes: Boundary-Layer pH Gradients and the Effect of Buffers
Springer Science and Business Media LLC - Tập 10 - Trang 1654-1661 - 1993
Tian-xiang Xiang, Bradley D. Anderson
The diffusion of weak acids or bases across planar lipid bilayer membranes results in aqueous boundary layer pH gradients. If not properly taken into account, such pH gradients will lead to errors in estimated membrane permeability coefficients, P m. The role of the permeant concentration, the buffer capacity, and the physicochemical properties of both permeant and buffer on the magnitude and impa...... hiện toàn bộ
Mechanistic Modeling of the Effect of Recombinant Human Hyaluronidase (rHuPH20) on Subcutaneous Delivery of Cetuximab in Rats
Springer Science and Business Media LLC - Tập 39 - Trang 1867-1880 - 2022
Xizhe Gao, Jongbong Lee, Kiran Deshpande, David W. Kang, Anas M. Fathallah, Leonid Kagan
To evaluate the duration of effect of rHuPH20 on SC absorption of cetuximab and to develop a mechanistic pharmacokinetic model linking the kinetics of rHuPH20 action with hyaluronan (HA) homeostasis and absorption of cetuximab from the SC space. Serum pharmacokinetics of cetuximab was evaluated after IV and SC dosing at 0.4 and 10 mg/kg (control groups). In test groups, SC cetuximab was administ...... hiện toàn bộ
Proton-Cotransport of Pravastatin Across Intestinal Brush-Border Membrane
Springer Science and Business Media LLC - Tập 12 - Trang 1727-1732 - 1995
Ikumi Tamai, Hitomi Takanaga, Hiroshi Maeda, Takuo Ogihara, Masaru Yoneda, Akira Tsuji
Purpose. The purpose of the present study is to clarify the intestinal brush-border transport mechanism of a weak organic acid, pravastatin, an HMG-CoA reductase inhibitor. Methods. The transport of pravastatin was studied by using intestinal brush-border membrane vesicles prepared from rabbit jejunum, and uptake by the membrane vesicles was measured using rapid filtration technique. Results. T...... hiện toàn bộ
New Safe Method for Preparation of Sarin-Exposed Human Erythrocytes Acetylcholinesterase Using Non-Toxic and Stable Sarin Analogue Isopropyl p-Nitrophenyl Methylphosphonate and its Application to Evaluation of Nerve Agent Antidotes
Springer Science and Business Media LLC - Tập 23 - Trang 2827-2833 - 2006
Hikoto Ohta, Takeshi Ohmori, Shinichi Suzuki, Hiroshi Ikegaya, Koichi Sakurada, Takehiko Takatori
A non-toxic and stable sarin analogue, isopropyl p-nitrophenyl methylphosphonate (INMP), was synthesized for safe preparation of sarin-exposed acetylcholinesterase (AChE). This agent was stable for years, able to be handled in an ordinary laboratory without special care, and its 50% inhibitory concentration (IC50) on 0.04 U/ml human erythrocytes AChE was 15 nM. This reagent was thought to be espec...... hiện toàn bộ
BOOK REVIEWS
Springer Science and Business Media LLC - Tập 7 - Trang 1330-1331 - 1990
Composition and Surface Charge of DNA-Loaded Microparticles Determine Maturation and Cytokine Secretion in Human Dendritic Cells
Springer Science and Business Media LLC - Tập 21 - Trang 1240-1247 - 2004
Samantha Jilek, Michael Ulrich, Hans P. Merkle, Elke Walter
Purpose. Biodegradable microparticles prepared from poly(lactide) (PLA) and poly(lactide-co-glycolide) (PLGA) have been shown to be promising carrier systems for vaccine delivery. Here, we have investigated the capacity of different PLA and PLGA microparticle formulations to induce stimulation of human blood monocyte-derived dendritic cells (DCs). Methods. Stimulation of human derived dendritic ...... hiện toàn bộ
Sugar-Grafted Cyclodextrin Nanocarrier as a “Trojan Horse” for Potentiating Antibiotic Activity
Springer Science and Business Media LLC - Tập 33 - Trang 1161-1174 - 2016
Min Li, Koon Gee Neoh, Liqun Xu, Liang Yuan, David Tai Leong, En-Tang Kang, Kim Lee Chua, Li Yang Hsu
The use of “Trojan Horse” nanocarriers for antibiotics to enhance the activity of antibiotics against susceptible and resistant bacteria is investigated. Antibiotic carriers (CD-MAN and CD-GLU) are prepared from β-cyclodextrin grafted with sugar molecules (D-mannose and D-glucose, respectively) via azide-alkyne click reaction. The sugar molecules serve as a chemoattractant enticing the bacteria to...... hiện toàn bộ
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