Excipient Interaction with Cetylpyridinium Chloride Activity in Tablet Based LozengesSpringer Science and Business Media LLC - - 1996
R. Michael E. Richards, James Z. Xing, Kirsty M. B. Mackay
Purpose. The purpose of the investigation was to determine the effect of tablet excipients on the activity of cetylpyridinium chloride (CPC) and the relative interaction between excipients and CPC.
Methods. An analytical assay was developed to evaluate the interaction between CPC and the excipients. In vivo activity was investigated using six volunteers by determining the reduction in colony for...... hiện toàn bộ
BOOK REVIEWSSpringer Science and Business Media LLC - Tập 7 - Trang 1330-1331 - 1990
Enhancing the Cellular Production of Extracellular Vesicles for Developing Therapeutic ApplicationsSpringer Science and Business Media LLC - Tập 40 - Trang 833-853 - 2022
Nina Erwin, Maria Fernanda Serafim, Mei He
Extracellular vesicles (EVs) have various advantageous properties, including a small size, high biocompatibility, efficient cargo loading, and precise cell targeting ability, making them promising tools for therapeutic development. EVs have been increasingly explored for applications like drug delivery. However, due to limited cellular secretion rates of EVs, wide-scale clinical applications are n...... hiện toàn bộ
The Role of Metabolites in BioequivalenceSpringer Science and Business Media LLC - Tập 21 - Trang 1331-1344 - 2004
Kamal K. Midha, Maureen J. Rawson, John W. Hubbard
The role of metabolites in bioequivalence studies has been a contentious issue for many years. Many papers have published recommendations for the use of metabolite data based on anecdotal evidence from the results of bioequivalence studies. Such anecdotal evidence has validity, but the arguments lack weight because the “correct” answers are always unknown. A more promising area of exploration is r...... hiện toàn bộ
MicroRNA-302 Replacement Therapy Sensitizes Breast Cancer Cells to Ionizing RadiationSpringer Science and Business Media LLC - Tập 30 - Trang 1008-1016 - 2012
Zhongxing Liang, Jeffrey Ahn, Donna Guo, John R. Votaw, Hyunsuk Shim
Solid tumors can be resistant or develop resistance to radiotherapy. The purpose of this study is to explore whether microRNA-302 is involved in radioresistance and can be exploited as a sensitizer to enhance sensitivity of breast cancer cells to radiation therapy. MiR-302 expression levels in radioresistant cell lines were analyzed in comparison with their parent cell lines. Furthermore, we inves...... hiện toàn bộ
The Use of Microcalorimetry to Measure Thermodynamic Parameters of the Binding of Ligands to InsulinSpringer Science and Business Media LLC - Tập 7 - Trang 606-611 - 1990
Scott E. McGraw, Siegfried Lindenbaum
Flow microcalorimetry was used to measure the free energies, enthalpies, and entropies of interactions between the hormone insulin and small ligand molecules or ions. Measurable amounts of heat were obtained for binding of four phenolic preservative molecules—phenol, meta-cresol, resorcinol, and methylparaben—to both two-zinc and zinc-free insulin and for binding of zinc ions to zinc-free insulin....... hiện toàn bộ