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Amyloidogenic determinants are usually not buried
Springer Science and Business Media LLC - Tập 9 - Trang 1-9 - 2009
Kimon K Frousios, Vassiliki A Iconomidou, Carolina-Maria Karletidi, Stavros J Hamodrakas
Amyloidoses are a group of usually fatal diseases, probably caused by protein misfolding and subsequent aggregation into amyloid fibrillar deposits. The mechanisms involved in amyloid fibril formation are largely unknown and are the subject of current, intensive research. In an attempt to identify possible amyloidogenic regions in proteins for further experimental investigation, we have developed ...... hiện toàn bộ
Structure of the dimeric N-glycosylated form of fungal β-N-acetylhexosaminidase revealed by computer modeling, vibrational spectroscopy, and biochemical studies
Springer Science and Business Media LLC - Tập 7 - Trang 1-14 - 2007
Rüdiger Ettrich, Vladimír Kopecký, Kateřina Hofbauerová, Vladimír Baumruk, Petr Novák, Petr Pompach, Petr Man, Ondřej Plíhal, Michal Kutý, Natallia Kulik, Jan Sklenář, Helena Ryšlavá, Vladimír Křen, Karel Bezouška
Fungal β-N-acetylhexosaminidases catalyze the hydrolysis of chitobiose into its constituent monosaccharides. These enzymes are physiologically important during the life cycle of the fungus for the formation of septa, germ tubes and fruit-bodies. Crystal structures are known for two monomeric bacterial enzymes and the dimeric human lysosomal β-N-acetylhexosaminidase. The fungal β-N-acetylhexosamini...... hiện toàn bộ
DWNN, a novel ubiquitin-like domain, implicates RBBP6 in mRNA processing and ubiquitin-like pathways
Springer Science and Business Media LLC - - 2006
D.J.R. Pugh, Eiso Ab, Andrew Faro, Portia Thandokazi Lutya, E. G. Hoffmann, D. J. G. Rees
Abstract Background RBBP6 is a 250 kDa splicing-associated protein that has been identified as an E3 ligase due to the presence of a RING finger domain. In humans and mice it interacts with both p53 and Rb, and plays a role in the induction of apoptosis and regulation of the cell cycle. RBBP6 has...... hiện toàn bộ
Rosetta Broker for membrane protein structure prediction: concentrative nucleoside transporter 3 and corticotropin-releasing factor receptor 1 test cases
Springer Science and Business Media LLC - Tập 17 Số 1 - 2017
Dorota Latek
Development of an accurate classification system of proteins into structured and unstructured regions that uncovers novel structural domains: its application to human transcription factors
Springer Science and Business Media LLC - Tập 9 - Trang 1-13 - 2009
Satoshi Fukuchi, Keiichi Homma, Yoshiaki Minezaki, Takashi Gojobori, Ken Nishikawa
In addition to structural domains, most eukaryotic proteins possess intrinsically disordered (ID) regions. Although ID regions often play important functional roles, their accurate identification is difficult. As human transcription factors (TFs) constitute a typical group of proteins with long ID regions, we regarded them as a model of all proteins and attempted to accurately classify TFs into st...... hiện toàn bộ
Crystal structure of subunit VPS25 of the endosomal trafficking complex ESCRT-II
Springer Science and Business Media LLC - Tập 4 - Trang 1-8 - 2004
Amy K Wernimont, Winfried Weissenhorn
Down-regulation of plasma membrane receptors via the endocytic pathway involves their monoubiquitylation, transport to endosomal membranes and eventual sorting into multi vesicular bodies (MVB) destined for lysosomal degradation. Successive assemblies of E ndosomal S orting C omplexes R equired for T ransport (ESCRT-I, -II and III) largely mediate sorting of plasma membrane receptors at endosomal ...... hiện toàn bộ
A knowledge-based structure-discriminating function that requires only main-chain atom coordinates
Springer Science and Business Media LLC - Tập 8 - Trang 1-15 - 2008
Yoshihide Makino, Nobuya Itoh
The use of knowledge-based potential function is a powerful method for protein structure evaluation. A variety of formulations that evaluate single or multiple structural features of proteins have been developed and studied. The performance of functions is often evaluated by discrimination ability using decoy structures of target proteins. A function that can evaluate coarse-grained structures is ...... hiện toàn bộ
Sequence analysis and structure prediction of type II Pseudomonas sp. USM 4–55 PHA synthase and an insight into its catalytic mechanism
Springer Science and Business Media LLC - Tập 6 - Trang 1-14 - 2006
Habibah A Wahab, Nurul Bahiyah Ahmad Khairudin, Mohd Razip Samian, Nazalan Najimudin
Polyhydroxyalkanoates (PHA), are biodegradable polyesters derived from many microorganisms such as the pseudomonads. These polyesters are in great demand especially in the packaging industries, the medical line as well as the paint industries. The enzyme responsible in catalyzing the formation of PHA is PHA synthase. Due to the limited structural information, its functional properties including ca...... hiện toàn bộ
Prediction of protein long-range contacts using an ensemble of genetic algorithm classifiers with sequence profile centers
Springer Science and Business Media LLC - Tập 10 Số Suppl 1 - Trang S2 - 2010
Peng Chen, Jinyan Li
A simple method for finding a protein’s ligand-binding pockets
Springer Science and Business Media LLC - - 2014
Seyed Majid Saberi Fathi, Jack A. Tuszyński
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