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Neuroprotective Effects of Exogenous Activin A on Oxygen-Glucose Deprivation in PC12 Cells
Springer Science and Business Media LLC - Tập 17 Số 1 - Trang 315-327
Jinting He, Jing Mang, Chunli Mei, Le Yang, Jiaoqi Wang, Ying Xing, Hong Yang, Zhongxin Xu
Ischemic cerebrovascular disease is one of the most common causes of death in the World. Exogenous activin A (ActA) protects neurons against toxicity and plays a central role in regulating the brain’s response to injury. In the present study, we investigated the mechanisms involved in the neuroprotective effects of ActA in a model of hypoxic-ischemic brain disease. We found that ActA could...... hiện toàn bộ
Pancreatic Lipase Inhibition by C-Glycosidic Flavones Isolated from Eremochloa ophiuroides
Springer Science and Business Media LLC - Tập 15 Số 11 - Trang 8251-8259
Eun Mi Lee, Seung Sik Lee, Byung Yeoup Chung, Jae‐Young Cho, In Chul Lee, So Ra Ahn, Soo Jeung Jang, Tae Ho Kim
Activity-guided fractionation of a methanolic extract of the leaves of Eremochloa ophiuroides (centipede grass) using a pancreatic lipase inhibitory assay led to the isolation and identification of a new C-glycosidic flavone, luteolin 6-C-b-D-boivinopyranoside (1), as well as eight known compounds. The structures of these compounds were established on the basis of interpretation of their s...... hiện toàn bộ
Indole Derivatives as Cyclooxygenase Inhibitors: Synthesis, Biological Evaluation and Docking Studies
Springer Science and Business Media LLC - Tập 23 Số 6 - Trang 1250
Muzamil Ahmad Bhat, Mohamed A. Al‐Omar, Mohammad Raish, Mushtaq A. Ansari, Hatem A. Abuelizz, Ahmed H. Bakheit, Ahmed M. Naglah
A new series of 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N′-[(E)-(substituted phenyl) methylidene] acetohydrazide derivatives (S1–S18) were synthesized and evaluated for their anti-inflammatory activity, analgesic activity, ulcerogenic activity, lipid peroxidation, ulcer index and cyclooxygenase expression activities. All the synthesized compounds were in good agreement with spectral and eleme...... hiện toàn bộ
Delivery of miRNA-Targeted Oligonucleotides in the Rat Striatum by Magnetofection with Neuromag®
Springer Science and Business Media LLC - Tập 23 Số 7 - Trang 1825
Simoneide Souza Titze-de-Almeida, Camila Hillesheim Horst, Cristina Soto-Sánchez, Eduardo Fernández, Ricardo Titze‐de‐Almeida
MicroRNAs (miRNAs) regulate gene expression at posttranscriptional level by triggering RNA interference. In such a sense, aberrant expressions of miRNAs play critical roles in the pathogenesis of many disorders, including Parkinson’s disease (PD). Controlling the level of specific miRNAs in the brain is thus a promising therapeutic strategy for neuroprotection. A fundamental need for miRNA...... hiện toàn bộ
Encapsulation of Essential Oils for the Development of Biosourced Pesticides with Controlled Release: A Review
Springer Science and Business Media LLC - Tập 24 Số 14 - Trang 2539
Bart Maes, Bouquillon, Marie‐Laure Fauconnier
Essential oil (EO) encapsulation can be carried out via a multitude of techniques, depending on applications. Because of EOs’ biological activities, the development of biosourced pesticides with EO encapsulation is of great interest. A lot of methods have been developed; they are presented in this review, together with the properties of the final products. Encapsulation conserves and prote...... hiện toàn bộ
Improving the Quality of Published Chemical Names with Nomenclature Software
Springer Science and Business Media LLC - Tập 11 Số 11 - Trang 915-928
Gernot A. Eller
This work deals with the use of organic systematic nomenclature in scientific literature, its quality, and computerized methods for its improvement. Criteria for classification of systematic names in terms of quality/correctness are discussed and applied to a sample set of several hundred names extracted from the literature. The same structures are named with three popular state-of-the-art...... hiện toàn bộ
Antibacterial Activity of Different Blossom Honeys: New Findings
Springer Science and Business Media LLC - Tập 24 Số 8 - Trang 1573
Marcela Bučeková, Lucia Jardekova, Valéria Juricová, Veronika Bugárová, Gabriele Di Marco, Angelo Gismondi, Donatella Leonardi, J. Farkašovská, Jana Godočı́ková, Maroš Laho, Jaroslav Klaudiny, V. Majtán, Antonella Canini, Juraj Majtán
Antibacterial activity is the most investigated biological property of honey. The goal of this study was to evaluate the antibacterial activity of 57 Slovak blossom honeys against Staphylococcus aureus and Pseudomonas aeruginosa and investigate the role of several bioactive substances in antibacterial action of honeys. Inhibitory and bactericidal activities of honeys were studied to determ...... hiện toàn bộ
Các Hoạt Động Chống Oxy Hóa Của Quercetin Và Các Phức Chất Của Nó Đối Với Ứng Dụng Y Học Dịch bởi AI
Springer Science and Business Media LLC - Tập 24 Số 6 - Trang 1123
Dong Xu, Meng-Jiao Hu, Yan-Qiu Wang, Yuan‐Lu Cui
Quercetin là một hợp chất sinh học có hoạt tính mạnh mẽ, được sử dụng rộng rãi trong y học thực vật và y học cổ truyền Trung Quốc nhờ vào hoạt động chống oxy hóa hiệu quả của nó. Trong những năm gần đây, hoạt động chống oxy hóa của quercetin đã được nghiên cứu một cách toàn diện, bao gồm tác động của nó lên glutathione (GSH), hoạt động enzyme, các con đường truyền tín hiệu và các loài oxy ...... hiện toàn bộ
Synthesis, Molecular Properties Prediction, and Anti-staphylococcal Activity of N-Acylhydrazones and New 1,3,4-Oxadiazole Derivatives
Springer Science and Business Media LLC - Tập 17 Số 5 - Trang 5095-5107
Cledualdo Soares de Oliveira, Bruno Freitas Lira, Vivyanne dos Santos Falcão-Silva, José P. Siqueira-Júnior, José Maria Barbosa‐Filho, Petrônio Filgueiras de Athayde-Filho
Five new 1-(2-(5-nitrofuran-2-yl)-5-(aryl)-1,3,4-oxadiazol-3-(2H)-yl) ethanone compounds 5a–e were synthesized by cyclization of N-acylhydrazones 4a–e with acetic anhydride under reflux conditions. Their structures were fully characterized by IR, 1H-NMR, and 13C-NMR. Furthermore, evaluations of the antibacterial activity of the 1,3,4-oxadiazoles 5a–e and N-acylhydrazones 4a–e showed strong...... hiện toàn bộ
Role of Gut Microbiota, Probiotics and Prebiotics in the Cardiovascular Diseases
Springer Science and Business Media LLC - Tập 26 Số 4 - Trang 1172
Anna Oniszczuk, Tomasz Oniszczuk, Marek Gancarz, Jolanta Szymańska
In recent years, there has been a growing interest in identifying and applying new, naturally occurring molecules that promote health. Probiotics are defined as “live microorganisms which, when administered in adequate amounts, confer health benefits on the host”. Quite a few fermented products serve as the source of probiotic strains, with many factors influencing the effectiveness of pro...... hiện toàn bộ
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