Pancreatic Lipase Inhibition by C-Glycosidic Flavones Isolated from Eremochloa ophiuroides

Springer Science and Business Media LLC - Tập 15 Số 11 - Trang 8251-8259
Eun Mi Lee1, Seung Sik Lee1, Byung Yeoup Chung1, Jae‐Young Cho2, In Chul Lee3, So Ra Ahn4, Soo Jeung Jang4, Tae Ho Kim4
1Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Institute (KAERI), Jeongeup 580-185, Korea;
2Department of Applied Life Sciences, Chonbuk National University, Jeonju 561-756, Korea
3Senior Industry Cluster Agency, Youngdong University, Youngdong 370-701, Korea;
4Department of Herbal Medicinal Pharmacology, Daegu Haany University, Gyeongsan 712-715, Korea;

Tóm tắt

Activity-guided fractionation of a methanolic extract of the leaves of Eremochloa ophiuroides (centipede grass) using a pancreatic lipase inhibitory assay led to the isolation and identification of a new C-glycosidic flavone, luteolin 6-C-b-D-boivinopyranoside (1), as well as eight known compounds. The structures of these compounds were established on the basis of interpretation of their spectroscopic data. Among these isolates, the C-glycosidic flavones 1–5 showed potent inhibitory effects on pancreatic lipase, with IC50 values ranging from 18.5 ± 2.6 to 50.5 ± 3.9 mM.

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Springer Science and Business Media LLC

Tập 15 Số 11

8251-8259

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