Các Hoạt Động Chống Oxy Hóa Của Quercetin Và Các Phức Chất Của Nó Đối Với Ứng Dụng Y Học
Tóm tắt
Quercetin là một hợp chất sinh học có hoạt tính mạnh mẽ, được sử dụng rộng rãi trong y học thực vật và y học cổ truyền Trung Quốc nhờ vào hoạt động chống oxy hóa hiệu quả của nó. Trong những năm gần đây, hoạt động chống oxy hóa của quercetin đã được nghiên cứu một cách toàn diện, bao gồm tác động của nó lên glutathione (GSH), hoạt động enzyme, các con đường truyền tín hiệu và các loài oxy phản ứng (ROS) do các yếu tố môi trường và độc học gây ra. Các nghiên cứu hóa học về quercetin chủ yếu tập trung vào hoạt động chống oxy hóa của các phức chất ion kim loại và các ion phức hợp của nó. Trong bài tổng quan này, chúng tôi nhấn mạnh những tiến bộ gần đây trong hoạt động chống oxy hóa, nghiên cứu hóa học và ứng dụng y học của quercetin.
Từ khóa
Tài liệu tham khảo
Rauf, 2018, Anticancer potential of quercetin: A comprehensive review, Phytother. Res., 32, 2109, 10.1002/ptr.6155
Almeida, 2018, Bioavailability of Quercetin in Humans with a Focus on Interindividual Variation, Compr. Rev. Food Sci. Food Saf., 17, 714, 10.1111/1541-4337.12342
Arulmoli, 2016, Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid, Pharmacogn. Rev., 10, 84, 10.4103/0973-7847.194044
Boots, 2008, Health effects of quercetin: From antioxidant to nutraceutical, Eur. J. Pharmacol., 585, 325, 10.1016/j.ejphar.2008.03.008
Xie, 2019, Depression caused by long-term stress regulates premature aging and is possibly associated with disruption of circadian rhythms in mice, Physiol. Behav., 199, 100, 10.1016/j.physbeh.2018.11.011
Halevas, 2017, Encapsulation of flavonoid quercetin in PEGylated SiO2 nanoparticles against Cu (II)-induced oxidative stress, Hell. J. Nucl. Med., 20, 156
Aytac, 2016, Quercetin/β-cyclodextrin inclusion complex embedded nanofibres: Slow release and high solubility, Food Chem., 197, 864, 10.1016/j.foodchem.2015.11.051
Anandam, 2014, Fabrication of cyclodextrin nanosponges for quercetin delivery: Physicochemical characterization, photostability, and antioxidant effects, J. Mater. Sci., 49, 8140, 10.1007/s10853-014-8523-6
Chen, 2006, CiteSpace II: Detecting and visualizing emerging trends and transient patterns in scientific literature, J. Am. Soc. Inf. Sci. Technol., 57, 359, 10.1002/asi.20317
Liao, H., Tang, M., Luo, L., Li, C., Chiclana, F., and Zeng, X.J. (2018). A bibliometric analysis and visualization of medical big data research. Sustainability, 10.
Tejada, 2017, Quercetin Effects on Exercise Induced Oxidative Stress and Inflammation, Curr. Org. Chem., 21, 348, 10.2174/1385272820666161017122202
Lesjak, 2018, Antioxidant and anti-inflammatory activities of quercetin and its derivatives, J. Funct. Foods, 40, 68, 10.1016/j.jff.2017.10.047
Kobori, 2015, Chronic high intake of quercetin reduces oxidative stress and induces expression of the antioxidant enzymes in the liver and visceral adipose tissues in mice, J. Funct. Foods, 15, 551, 10.1016/j.jff.2015.04.006
Bravo, 2012, Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38, Chem. Biol. Interact., 195, 154, 10.1016/j.cbi.2011.12.005
Kinaci, 2012, Effects of quercetin on apoptosis, NF-κB and NOS gene expression in renal ischemia/reperfusion injury, Exp. Ther. Med., 3, 249, 10.3892/etm.2011.382
Gao, 2018, Glutathione homeostasis is significantly altered by quercetin via the Keapl/Nrf2 and MAPK signaling pathways in rats, J. Clin. Biochem. Nutr., 62, 56, 10.3164/jcbn.17-40
Ademosun, 2016, Antioxidative Properties and Effect of Quercetin and Its Glycosylated Form (Rutin) on Acetylcholinesterase and Butyrylcholinesterase Activities, J. Evid. Based Complement. Altern. Med., 21, Np11, 10.1177/2156587215610032
Adedara, 2017, Quercetin Improves Neurobehavioral Performance through Restoration of Brain Antioxidant Status and Acetylcholinesterase Activity in Manganese-Treated Rats, Neurochem. Res., 42, 1219, 10.1007/s11064-016-2162-z
Chen, 2017, Pretreated quercetin protects gerbil hippocampal CA1 pyramidal neurons from transient cerebral ischemic injury by increasing the expression of antioxidant enzymes, Neural Regen. Res., 12, 220, 10.4103/1673-5374.200805
Braun, 2011, Quercetin protects primary human osteoblasts exposed to cigarette smoke through activation of the antioxidative enzymes HO-1 and SOD-1, Sci. World J., 11, 2348, 10.1100/2011/471426
Akkoyun, 2016, Quercetin Inhibits Heart Injury in Lipopolysaccharide-induced Endotoxemic Model by Suppressing the Effects of Reactive Oxygen Species, Anal. Quant. Cytopathol. Histopathol., 38, 183
Kawamura, 2018, Potential relationship between the biological effects of low-dose irradiation and mitochondrial ROS production, J. Radiat. Res., 59, ii91, 10.1093/jrr/rrx091
Zhao, 2017, ROS signaling under metabolic stress: Cross-talk between AMPK and AKT pathway, Mol. Cancer, 16, 79, 10.1186/s12943-017-0648-1
Jalmi, 2015, ROS mediated MAPK signaling in abiotic and biotic stress-striking similarities and differences, Front. Plant Sci., 6, 769, 10.3389/fpls.2015.00769
Stoiber, 2015, The role of reactive oxygen species (ROS) in the formation of extracellular traps (ETs) in humans, Biomolecules, 5, 702, 10.3390/biom5020702
Vurusaner, 2012, Tumor suppressor genes and ROS: Complex networks of interactions, Free Radic. Biol. Med., 52, 7, 10.1016/j.freeradbiomed.2011.09.035
Song, 2013, Antioxidant effect of quercetin against acute spinal cord injury in rats and its correlation with the p38MAPK/iNOS signaling pathway, Life Sci., 92, 1215, 10.1016/j.lfs.2013.05.007
Chen, 2017, Quercetin ameliorates imiquimod-induced psoriasis-like skin inflammation in mice via the NF-κB pathway, Int. Immunopharmacol., 48, 110, 10.1016/j.intimp.2017.04.022
Hung, 2015, Quercetin is a potent anti-atherosclerotic compound by activation of SIRT1 signaling under oxLDL stimulation, Mol. Nutr. Food Res., 59, 1905, 10.1002/mnfr.201500144
Lu, 2017, Quercetin attenuates high fructose feeding-induced atherosclerosis by suppressing inflammation and apoptosis via ROS-regulated PI3K/AKT signaling pathway, Biomed. Pharmacother., 85, 658, 10.1016/j.biopha.2016.11.077
Chang, 2014, Quercetin enhances exercise-mediated neuroprotective effects in brain ischemic rats, Med. Sci. Sports Exerc., 46, 1908, 10.1249/MSS.0000000000000310
Du, 2017, Quercetin inhibited epithelial mesenchymal transition in diabetic rats, high-glucose-cultured lens, and SRA01/04 cells through transforming growth factor-beta2/phosphoinositide 3-kinase/Akt pathway, Mol. Cell. Endocrinol., 452, 44, 10.1016/j.mce.2017.05.011
Peng, 2017, Hepatoprotective effect of quercetin against LPS/d-GalN induced acute liver injury in mice by inhibiting the IKK/NF-κB and MAPK signal pathways, Int. Immunopharmacol., 52, 281, 10.1016/j.intimp.2017.09.022
Jin, 2019, Quercetin attenuates toosendanin-induced hepatotoxicity through inducing the Nrf2/GCL/GSH antioxidant signaling pathway, Acta Pharmacol. Sin., 40, 75, 10.1038/s41401-018-0024-8
Zhu, 2017, Quercetin prevents alcohol-induced liver injury through targeting of PI3K/Akt/nuclear factor-κB and STAT3 signaling pathway, Exp. Ther. Med., 14, 6169
Ji, 2015, The involvement of p62-Keap1-Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity, Free Radic. Biol. Med., 85, 12, 10.1016/j.freeradbiomed.2015.03.035
Dong, 2014, Quercetin attenuates doxorubicin cardiotoxicity by modulating Bmi-1 expression, Br. J. Pharmacol., 171, 4440, 10.1111/bph.12795
Ma, 2015, Quercetin protects mouse liver against CCl(4)-induced inflammation by the TLR2/4 and MAPK/NF-κB pathway, Int. Immunopharmacol., 28, 531, 10.1016/j.intimp.2015.06.036
Liu, 2013, Protective effect of quercetin on lead-induced oxidative stress and endoplasmic reticulum stress in rat liver via the IRE1/JNK and PI3K/Akt pathway, Free Radic. Res., 47, 192, 10.3109/10715762.2012.760198
Gupta, 2017, Protective Role of Quercetin in Cadmium-Induced Cholinergic Dysfunctions in Rat Brain by Modulating Mitochondrial Integrity and MAP Kinase Signaling, Mol. Neurobiol., 54, 4560, 10.1007/s12035-016-9950-y
Pratheeshkumar, 2017, Quercetin inhibits Cr (VI)-induced malignant cell transformation by targeting miR-21-PDCD4 signaling pathway, Oncotarget, 8, 52118, 10.18632/oncotarget.10130
Dong, 2017, Quercetin ameliorates learning and memory via the Nrf2-ARE signaling pathway in d-galactose-induced neurotoxicity in mice, Biochem. Biophys. Res. Commun., 491, 636, 10.1016/j.bbrc.2017.07.151
Wattel, 2004, Flavonoid quercetin differentiation decreases osteoclastic induced by RANKL via a mechanism involving NF-κB and AP-1, J. Cell. Biochem., 92, 285, 10.1002/jcb.20071
Jin, 2016, Amelioration of particulate matter-induced oxidative damage by vitamin c and quercetin in human bronchial epithelial cells, Chemosphere, 144, 459, 10.1016/j.chemosphere.2015.09.023
Casagrande, 2006, Protective effect of topical formulations containing quercetin against UVB-induced oxidative stress in hairless mice, J. Photochem. Photobiol. B, 84, 21, 10.1016/j.jphotobiol.2006.01.006
Zhu, 2017, Protective effects of quercetin on UVB irradiation-induced cytotoxicity through ROS clearance in keratinocyte cells, Oncol. Rep., 37, 209, 10.3892/or.2016.5217
Zerin, 2013, Quercetin reduces oxidative damage induced by paraquat via modulating expression of antioxidant genes in A549 cells, J. Appl. Toxicol., 33, 1460, 10.1002/jat.2812
Hu, 2015, Quercetin protects gastric epithelial cell from oxidative damage in vitro and in vivo, Eur. J. Pharmacol., 754, 115, 10.1016/j.ejphar.2015.02.007
Tvrda, 2016, Protective Effects of Quercetin on Selected Oxidative Biomarkers in Bovine Spermatozoa Subjected to Ferrous Ascorbate, Reprod. Domest. Anim., 51, 524, 10.1111/rda.12714
Kale, 2018, Neuroprotective effects of Quercetin on radiation-induced brain injury in rats, J. Radiat. Res., 59, 404, 10.1093/jrr/rry032
Zargar, 2016, Therapeutic role of quercetin on oxidative damage induced by acrylamide in rat brain, Pharm. Biol., 54, 1763, 10.3109/13880209.2015.1127977
Ola, 2017, Neuroprotective effects of quercetin in diabetic rat retina, Saudi J. Biol. Sci., 24, 1186, 10.1016/j.sjbs.2016.11.017
Heo, 2004, Protective effects of quercetin and vitamin C against oxidative stress-induced neurodegeneration, J. Agric. Food Chem., 52, 7514, 10.1021/jf049243r
Zargar, 2015, Protective effects of quercetin on cadmium fluoride induced oxidative stress at different intervals of time in mouse liver, Acta Biochim. Pol., 62, 207, 10.18388/abp.2014_900
Patil, 2014, Antigenotoxic potential of rutin and quercetin in Swiss mice exposed to gamma radiation, Biomed. J., 37, 305, 10.4103/2319-4170.132880
Ozyurt, 2014, Quercetin protects radiation-induced DNA damage and apoptosis in kidney and bladder tissues of rats, Free Radic. Res., 48, 1247, 10.3109/10715762.2014.945925
Patil, 2013, Antioxidative and radioprotective potential of rutin and quercetin in Swiss albino mice exposed to gamma radiation, J. Med. Phys., 38, 87, 10.4103/0971-6203.111321
Kalantari, 2018, Antioxidant and hepatoprotective effects of Capparis spinosa L. fractions and Quercetin on tert-butyl hydroperoxide- induced acute liver damage in mice, J. Tradit. Complement. Med., 81, 120, 10.1016/j.jtcme.2017.04.010
Prasad, 2013, Quercetin reverses hypobaric hypoxia-induced hippocampal neurodegeneration and improves memory function in the rat, High Alt. Med. Biol., 14, 383, 10.1089/ham.2013.1014
Yarahmadi, 2017, Protective effects of quercetin on nicotine induced oxidative stress in ‘HepG2 cells’, Toxicol. Mech. Methods, 27, 609, 10.1080/15376516.2017.1344338
Chen, 2005, Pharmacokinetics and modeling of quercetin and metabolites, Pharm. Res., 22, 892, 10.1007/s11095-005-4584-1
Roy, 2018, Vanadium quercetin complex attenuates mammary cancer by regulating the P53, Akt/mTOR pathway and downregulates cellular proliferation correlated with increased apoptotic events, Biometals, 31, 647, 10.1007/s10534-018-0117-3
Bratu, 2014, Biological Activities of Zn (II) and Cu (II) Complexes with Quercetin and Rutin: Antioxidant Properties and UV-Protection Capacity, Rev. Chim., 65, 544
Bukhari, 2009, Synthesis, characterization and antioxidant activity copper-quercetin complex, Spectrochim. Acta Part A, 71, 1901, 10.1016/j.saa.2008.07.030
Ghosh, 2015, Synthesis, characterization and study of antioxidant activity of quercetin-magnesium complex, Spectrochim. Acta A Mol. Biomol. Spectrosc., 151, 807, 10.1016/j.saa.2015.07.050
Raza, 2016, Quercetin-Iron Complex: Synthesis, Characterization, Antioxidant, DNA Binding, DNA Cleavage, and Antibacterial Activity Studies, J. Fluoresc., 26, 2023, 10.1007/s10895-016-1896-y
Roy, 2018, Deciphering the biochemical and molecular mechanism underlying the in vitro and in vivo chemotherapeutic efficacy of ruthenium quercetin complex in colon cancer, Mol. Carcinog., 57, 700, 10.1002/mc.22792
Trifunschi, 2016, Synthesis, Characterization and Antioxidant Activity of Co (II) and Cd (II) Complexes with Quercetin, Rev. Chim., 67, 2422
Simoes, 2013, Synthesis, characterization and study of the properties of a new mononuclear quercetin complex containing Ga (III) ions, Quim. Nova, 36, 495
Zhou, 2001, Synthesis, characterization, antioxidative and antitumor activities of solid quercetin rare earth (III) complexes, J. Inorg. Biochem., 83, 41, 10.1016/S0162-0134(00)00128-8
Ravichandran, 2014, Structural characterization and physicochemical properties of quercetin-Pb complex, J. Coord. Chem., 67, 1449, 10.1080/00958972.2014.915317
Mokhtarzadeh, 2014, Synthesis, Characterization and Antioxidant Property of Quercetin-Tb (III) Complex, Adv. Pharm. Bull., 4, 101
Xu, 2016, Quercetin phospholipid complex significantly protects against oxidative injury in ARPE-19 cells associated with activation of Nrf2 pathway, Eur. J. Pharmacol., 770, 1, 10.1016/j.ejphar.2015.11.050
Singh, 2012, Quercetin-phospholipid complex: An amorphous pharmaceutical system in herbal drug delivery, Curr. Drug Discov. Technol., 9, 17, 10.2174/157016312799304507
Oliver, 2018, Water Soluble Antioxidant Dextran-Quercetin Conjugate with Potential Anticancer Properties, Macromol. Biosci., 18, e1700239, 10.1002/mabi.201700239
Patra, 2017, Calcium phosphate-quercetin nanocomposite (CPQN): A multi-functional nanoparticle having pH indicating, highly fluorescent and anti-oxidant properties, Colloids Surf. B. Biointerfaces, 154, 63, 10.1016/j.colsurfb.2017.03.018
Guo, 2014, Facile synthesis of multifunctional germanium nanoparticles as a carrier of quercetin to achieve enhanced biological activity, Chem. Asian J., 9, 2272, 10.1002/asia.201402227
Matschke, 2019, Oxidative stress: The lowest common denominator of multiple diseases, Neural Regen. Res., 14, 238, 10.4103/1673-5374.244780
Tan, 2018, Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases, Front. Pharmacol., 9, 1162, 10.3389/fphar.2018.01162
Lubrano, 2015, Enzymatic antioxidant system in vascular inflammation and coronary artery disease, World J. Exp. Med., 5, 218, 10.5493/wjem.v5.i4.218
Rodrigo, 2011, Modulation of endogenous antioxidant system by wine polyphenols in human disease, Clin. Chim. Acta, 412, 410, 10.1016/j.cca.2010.11.034
Maurya, 2015, Anticarcinogenic action of quercetin by downregulation of phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) via induction of p53 in hepatocellular carcinoma (HepG2) cell line, Mol. Biol. Rep., 42, 1419, 10.1007/s11033-015-3921-7
Maurya, 2015, Modulation of PKC signaling and induction of apoptosis through suppression of reactive oxygen species and tumor necrosis factor receptor 1 (TNFR1): Key role of quercetin in cancer prevention, Tumour Biol., 36, 8913, 10.1007/s13277-015-3634-5
Sharmila, 2014, Chemopreventive effect of quercetin in MNU and testosterone induced prostate cancer of Sprague-Dawley rats, Nutr. Cancer, 66, 38, 10.1080/01635581.2014.847967
Sharmila, 2014, Chemopreventive effect of quercetin, a natural dietary flavonoid on prostate cancer in in vivo model, Clin. Nutr., 33, 718, 10.1016/j.clnu.2013.08.011
Ali, 2015, Quercetin attenuates the development of 7, 12-dimethyl benz (a) anthracene (DMBA) and croton oil-induced skin cancer in mice, J. Biomed. Res., 29, 139, 10.7555/JBR.29.20130025
Li, 2016, Protective mechanism of quercetin on acute myocardial infarction in rats, Genet. Mol. Res., 15, 15017117
Jing, 2016, Protective Effect of Quercetin on Posttraumatic Cardiac Injury, Sci. Rep., 6, 30812, 10.1038/srep30812
Mehta, 2017, Quercetin prevents chronic unpredictable stress induced behavioral dysfunction in mice by alleviating hippocampal oxidative and inflammatory stress, Physiol. Behav., 171, 69, 10.1016/j.physbeh.2017.01.006
Holzmann, 2015, Antidepressant-like effect of quercetin in bulbectomized mice and involvement of the antioxidant defenses, and the glutamatergic and oxidonitrergic pathways, Pharmacol. Biochem. Behav., 136, 55, 10.1016/j.pbb.2015.07.003
Sherif, 2018, Uroprotective mechanism of quercetin against cyclophosphamide-induced urotoxicity: Effect on oxidative stress and inflammatory markers, J. Cell. Biochem., 119, 7441, 10.1002/jcb.27053
Maksymchuk, 2017, Quercetin prevents type 1 diabetic liver damage through inhibition of CYP2E1, Pharmacol. Rep., 69, 1386, 10.1016/j.pharep.2017.05.020
Adedara, 2017, Chemoprotective role of quercetin in manganese-induced toxicity along the brain-pituitary-testicular axis in rats, Chem. Biol. Interact., 263, 88, 10.1016/j.cbi.2016.12.019
Taslidere, 2016, Quercetin protection against ciprofloxacin induced liver damage in rats, Biotech. Histochem., 91, 116, 10.3109/10520295.2015.1085093
Wang, 2015, Quercetin ameliorates liver injury induced with Tripterygium glycosides by reducing oxidative stress and inflammation, Can. J. Physiol. Pharmacol., 93, 427, 10.1139/cjpp-2015-0038
Unsal, 2015, Role of quercetin in cadmium-induced oxidative stress, neuronal damage, and apoptosis in rats, Toxicol. Ind. Health, 31, 1106, 10.1177/0748233713486960
Olayinka, 2015, Quercetin, a Flavonoid Antioxidant, Ameliorated Procarbazine-Induced Oxidative Damage to Murine Tissues, Antioxidants, 4, 304, 10.3390/antiox4020304
Jahan, 2015, Alleviative effect of quercetin on rat testis against arsenic: A histological and biochemical study, Syst. Biol. Reprod. Med., 61, 89, 10.3109/19396368.2014.998350
Huang, 2015, Quercetin protects against lipopolysaccharide-induced acute lung injury in rats through suppression of inflammation and oxidative stress, Arch. Med. Sci., 11, 427, 10.5114/aoms.2015.50975
Almaghrabi, 2015, Molecular and biochemical investigations on the effect of quercetin on oxidative stress induced by cisplatin in rat kidney, Saudi J. Biol. Sci., 22, 227, 10.1016/j.sjbs.2014.12.008
Yazici, 2018, Protective Effects of Quercetin on Necrotizing Enterocolitis in a Neonatal Rat Model, Am. J. Perinatol., 35, 434, 10.1055/s-0037-1608660
Yao, Z., Gu, Y., Zhang, Q., Liu, L., Meng, G., Wu, H., Xia, Y., Bao, X., Shi, H., and Sun, S. (2018). Estimated daily quercetin intake and association with the prevalence of type 2 diabetes mellitus in Chinese adults. Eur. J. Nutr.
Veith, 2017, The disturbed redox-balance in pulmonary fibrosis is modulated by the plant flavonoid quercetin, Toxicol. Appl. Pharmacol., 336, 40, 10.1016/j.taap.2017.10.001
Farrag, 2018, Preparation of starch nanoparticles loaded with quercetin using nanoprecipitation technique, Int. J. Biol. Macromol., 114, 426, 10.1016/j.ijbiomac.2018.03.134
Han, 2018, Quercetin nanoparticles with enhanced bioavailability as multifunctional agents toward amyloid induced neurotoxicity, J. Mater. Chem. B, 6, 1387, 10.1039/C7TB03053C
Aghapour, 2018, Quercetin conjugated with silica nanoparticles inhibits tumor growth in MCF-7 breast cancer cell lines, Biochem. Biophys. Res. Commun., 500, 860, 10.1016/j.bbrc.2018.04.174
Vijayakumar, 2017, Quercetin-Loaded Solid Lipid Nanoparticle Dispersion with Improved Physicochemical Properties and Cellular Uptake, AAPS PharmSciTech, 18, 875, 10.1208/s12249-016-0573-4
Patra, 2018, Formulation and evaluation of mixed polymeric micelles of quercetin for treatment of breast, ovarian, and multidrug resistant cancers, Int. J. Nanomed., 13, 2869, 10.2147/IJN.S153094
Ahmad, 2018, Intranasal delivery of quercetin-loaded mucoadhesive nanoemulsion for treatment of cerebral ischaemia, Artif. Cells Nanomed. Biotechnol., 46, 717, 10.1080/21691401.2017.1337024
Ramadon, 2017, In vitro Penetration and Bioavailability of Novel Transdermal Quercetin-loaded Ethosomal Gel, Indian J. Pharm. Sci., 79, 948, 10.4172/pharmaceutical-sciences.1000312
Khor, 2017, Preparation and characterization of quercetin/dietary fiber nanoformulations, Carbohydr. Polym., 161, 109, 10.1016/j.carbpol.2016.12.059