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In Silico Analysis for Determination and Validation of Human CD20 Antigen 3D Structure
Springer Science and Business Media LLC - Tập 25 - Trang 123-135 - 2017
Zahra Payandeh, Masoumeh Rajabibazl, Yousef Mortazavi, Azam Rahimpour
CD20 has been known as an attractive therapeutic target for refractory diseases such as B-cell chronic lymphocytic leukemia, rheumatoid arthritis and multiple sclerosis. Determining the 3D structure of the CD20 antigen could help to achieve a better deduction of its functions and its interactions with ligands. In this regard, we have launched an in silico protein modeling strategy to unveil the pr...... hiện toàn bộ
Application of Antimicrobial Peptides in the Design and Production of Anticancer Agents
Springer Science and Business Media LLC -
Bahareh Vakili, Ali Jahanian-Najafabadi
Đánh giá các đặc tính chức năng của protein thủy phân từ mầm lúa mì và tác động của nó đến các đặc tính vật lý - hóa học của sữa chua đông lạnh Dịch bởi AI
Springer Science and Business Media LLC - Tập 28 Số 2 - Trang 1-12 - 2022
Ghelich, Sekineh, Ariaii, Peiman, Ahmadi, Mohammad
Trong nghiên cứu này, tác động của protein thủy phân từ mầm lúa mì (WGPH) lên các đặc tính vật lý - hóa học và cảm quan của sữa chua đông lạnh đã được điều tra. Để thực hiện điều này, trước tiên, WGPH được sản xuất bằng cách sử dụng hai enzyme, alcalase và flavourzyme, và các đặc tính chức năng của nó đã được xác định để tìm ra enzyme tối ưu. Sau đó, 4 loại sữa chua đông lạnh được chuẩn bị, bao gồ...... hiện toàn bộ
#WGPH #protein thủy phân #mầm lúa mì #sữa chua đông lạnh #đặc tính vật lý - hóa học #enzyme alcalase #cảm quan
Using Immunoinformatics and Structural Approaches to Design a Novel HHV8 Vaccine
Springer Science and Business Media LLC - Tập 26 - Trang 321-331 - 2019
Behzad Dehghani, Tayebeh Hashempour, Zahra Hasanshahi
Kaposi’s sarcoma (KS)-associated herpesvirus (KSHV) or human herpesvirus 8 (HHV8) has caused infection in different parts of the world, especially in Africa, the Middle East, and the Mediterranean. HHV8 is a gamma-2 class herpesvirus and its genome contains 26 open reading frames. K1 is a highly variable glycoprotein and can be used as a vaccine candidate. The aim of this study was to design a new...... hiện toàn bộ
Anti-inflammatory and Antioxidant Peptide-Conjugates: Modulation of Activity by Charged and Hydrophobic Residues
Springer Science and Business Media LLC - Tập 25 - Trang 227-234 - 2017
K. P. Rakesh, R. Suhas, D. Channe Gowda
In the present study, antioxidant and anti-inflammatory activities of a series of quinazolinone-conjugated-peptides were investigated. Substitution of second position of the peptide template ‘GXGVP’ by different amino acids of varying hydrophobicity, charge and polarity has been studied. Quinazolinone-peptides with Trp residue emerged out as the highly potential antioxidant whereas the conjugate w...... hiện toàn bộ
Solid Phase Synthesis of Dual Labeled Peptides: Development of Cell Permeable Calpain Specific Substrates
Springer Science and Business Media LLC - Tập 13 - Trang 83-91 - 2006
Brian M. Polster, Rafael Arze, Matthew H. Lyttle, David G. Nicholls, Derek Hudson
A step-by-step evaluation of dual-labeled FRET substrates for the protease calpain is reported. The study led to cell permeable selections, with optimized specificity and effectiveness for the target enzyme, and improved stability to non-specific degrading enzymes.
Structural Characteristics, Prokaryotic Expression and Activity Analysis of Antimicrobial Peptide ALFPm10 from Penaeus monodon
Springer Science and Business Media LLC - - 2022
Guoqiang Li, Jiawen Chen, Junfeng Li, Chenjing Shang, Chaogang Wang
Heterologous Prime Boost Regimes with N-terminal Peptides of Ag85B Induces Better Protection than Ag85B and BCG in Murine Model of Tuberculosis
Springer Science and Business Media LLC - - 2015
Aliabbas A. Husain, Hatim F. Daginawala, Shubhangi R. Warke, Dewanand R. Kalorey, Nitin V. Kurkure, Amit R. Nayak, Hemant J. Purohit, Girdhar M. Taori, Rajpal S. Kashyap
Limited experimental evidences are available on the use of peptides as vaccines to boost BCG induced immunity for protection against tuberculosis. The present study therefore evaluated protective efficacy of booster dose of N-terminal peptides of Ag85B, using prime boost approaches in murine model of tuberculosis. Using earlier established subcutaneous murine model of TB in our laboratory, we comp...... hiện toàn bộ
Investigation of the Feasibility of an Amide-based Prodrug Under Physiological Conditions
Springer Science and Business Media LLC - Tập 14 - Trang 393-393 - 2008
Arnab De, Richard D. DiMarchi
Modulating the Antimicrobial Activity of Temporin L Through Introduction of Fluorinated Phenylalanine
Springer Science and Business Media LLC - Tập 23 - Trang 213-225 - 2016
Subbaiah Chennam Setty, Soyar Horam, Mukesh Pasupuleti, Wahajul Haq
Antimicrobial peptides (AMPs) are the promising future therapeutic candidates because of their multifunctional roles and unique mode of action against microbes. Despite several advantages, developing AMPs into therapeutic antibiotics is often associated with limitations, such as thermal and enzymatic stability, moderate antimicrobial activity and higher toxicity. We here report the synthesis of 2-...... hiện toàn bộ
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