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Purification, Characterization and Antibacterial Properties of Peptide from Marine Ascidian Didemnum sp.
Springer Science and Business Media LLC - Tập 26 - Trang 201-208 - 2019
Marine ecosystems are unique and a largely diverse chest of natural resources which are still to be explored for new marine species. They are still unexplored for their pharmacological properties. Ascidians or sea squirts are invertebrate and fruitful candidate of a wide variety of biologically active secondary metabolites from cyclic peptides to aromatic alkaloids. In this study, we have purified......
In Silico Analysis for Determination and Validation of Human CD20 Antigen 3D Structure
Springer Science and Business Media LLC - Tập 25 - Trang 123-135 - 2017
CD20 has been known as an attractive therapeutic target for refractory diseases such as B-cell chronic lymphocytic leukemia, rheumatoid arthritis and multiple sclerosis. Determining the 3D structure of the CD20 antigen could help to achieve a better deduction of its functions and its interactions with ligands. In this regard, we have launched an in silico protein modeling strategy to unveil the pr......
Application of Antimicrobial Peptides in the Design and Production of Anticancer Agents
Springer Science and Business Media LLC -
Đánh giá các đặc tính chức năng của protein thủy phân từ mầm lúa mì và tác động của nó đến các đặc tính vật lý - hóa học của sữa chua đông lạnh Dịch bởi AI
Springer Science and Business Media LLC - Tập 28 Số 2 - Trang 1-12 - 2022
Trong nghiên cứu này, tác động của protein thủy phân từ mầm lúa mì (WGPH) lên các đặc tính vật lý - hóa học và cảm quan của sữa chua đông lạnh đã được điều tra. Để thực hiện điều này, trước tiên, WGPH được sản xuất bằng cách sử dụng hai enzyme, alcalase và flavourzyme, và các đặc tính chức năng của nó đã được xác định để tìm ra enzyme tối ưu. Sau đó, 4 loại sữa chua đông lạnh được chuẩn bị, bao gồ......
#WGPH #protein thủy phân #mầm lúa mì #sữa chua đông lạnh #đặc tính vật lý - hóa học #enzyme alcalase #cảm quan
Cytotoxicity and Antibacterial Effect of Trp-Substituted CM11 Cationic Peptide Against Drug-Resistant Isolates of Brucella melitensis Alone and in Combination with Recommended Antibiotics
Springer Science and Business Media LLC - Tập 25 - Trang 235-245 - 2018
During the recent years, antibiotic resistance of pathogenic bacteria to conventional and common antibiotics has considered as a global concern. Therefore, researchers attend to find a new class of antimicrobial agents such as antimicrobial peptides (AMP), but some limitations are on the therapeutic use of AMPs such as cytotoxicity. To overcome these limitations various strategies have been descri......
Using Immunoinformatics and Structural Approaches to Design a Novel HHV8 Vaccine
Springer Science and Business Media LLC - Tập 26 - Trang 321-331 - 2019
Kaposi’s sarcoma (KS)-associated herpesvirus (KSHV) or human herpesvirus 8 (HHV8) has caused infection in different parts of the world, especially in Africa, the Middle East, and the Mediterranean. HHV8 is a gamma-2 class herpesvirus and its genome contains 26 open reading frames. K1 is a highly variable glycoprotein and can be used as a vaccine candidate. The aim of this study was to design a new......
Antitumoral and Antimicrobial Activity of Surfactin Extracted from Bacillus subtilis KLP2015
Springer Science and Business Media LLC - Tập 26 - Trang 423-433 - 2019
Surfactin lipopeptide (SLP) from Bacillus subtilis KLP2015 (Accession number KT459335) was extracted and purified by ammonium sulphate precipitation, DEAE and size exclusion chromatography. The molecular mass of the purified Surfactin lipopeptide was determined ~ 1000 Dalton through ESI-MS and MALDI-TOF-MS/MS analysis. The purified Surfactin possessed a strong cytotoxicity towards tested mammalian......
Anti-inflammatory and Antioxidant Peptide-Conjugates: Modulation of Activity by Charged and Hydrophobic Residues
Springer Science and Business Media LLC - Tập 25 - Trang 227-234 - 2017
In the present study, antioxidant and anti-inflammatory activities of a series of quinazolinone-conjugated-peptides were investigated. Substitution of second position of the peptide template ‘GXGVP’ by different amino acids of varying hydrophobicity, charge and polarity has been studied. Quinazolinone-peptides with Trp residue emerged out as the highly potential antioxidant whereas the conjugate w......
PepEngine: A Manually Curated Structural Database of Peptides Containing α, β- Dehydrophenylalanine (ΔPhe) and α-Amino Isobutyric Acid (Aib)
Springer Science and Business Media LLC - Tập 28 - Trang 1-11 - 2022
Protein design is the systematic and rational design of protein/peptide molecules for various purposes such as improved activity, novel function, understanding structure–activity relationships (SARs) etc. A common approach to protein design involves methodical and sequential linking of various independently stable structural motifs to arrive at the desired global architecture. Non-standard amino a......
Solid Phase Synthesis of Dual Labeled Peptides: Development of Cell Permeable Calpain Specific Substrates
Springer Science and Business Media LLC - Tập 13 - Trang 83-91 - 2006
A step-by-step evaluation of dual-labeled FRET substrates for the protease calpain is reported. The study led to cell permeable selections, with optimized specificity and effectiveness for the target enzyme, and improved stability to non-specific degrading enzymes.
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