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From Venom to AChE Inhibitor: Design, Molecular Modeling, and Synthesis of a Peptidic Inhibitor of AChE
Springer Science and Business Media LLC - Tập 27 - Trang 463-474 - 2020
Dara Dastan, Kiana Fasihi, Ahmad Ebadi
Alzheimer’s disease (AD) is an irreversible and progressive brain disorder that slowly destroys memory and cognitive skills. The current treatment of AD mainly focused on the restoring of ACh levels through acetylcholinesterase (AChE) inhibition. Peptides are a unique class of pharmaceutical compounds that have privilege over small molecules, especially in the realm of protein–protein interactions... hiện toàn bộ
Improvement of the Antioxidant Activity of Fenugreek Protein Isolates by Lactococcus lactis Fermentation
Springer Science and Business Media LLC - Tập 24 - Trang 499-509 - 2017
Khaoula Setti, Faten Kachouri, Moktar Hamdi
This study investigated the antioxidant capacity of fenugreek protein isolate and its improvement by Lc. lactis fermentation through bioactive peptides production and the effect of molecular weight variation on fenugreek fractions antioxidant activity. Fenugreek protein isolate showed a significant increase of antioxidant and radical scavenging activity after 24 h of fermentation, by about 23.7, 4... hiện toàn bộ
Purification, Characterization and Antibacterial Properties of Peptide from Marine Ascidian Didemnum sp.
Springer Science and Business Media LLC - Tập 26 - Trang 201-208 - 2019
Velusamy Arumugam, Manigandan Venkatesan, Karthik Ramachandran, Saravanan Ramachandran, Satheesh Kumar Palanisamy, Umamaheswari Sundaresan
Marine ecosystems are unique and a largely diverse chest of natural resources which are still to be explored for new marine species. They are still unexplored for their pharmacological properties. Ascidians or sea squirts are invertebrate and fruitful candidate of a wide variety of biologically active secondary metabolites from cyclic peptides to aromatic alkaloids. In this study, we have purified... hiện toàn bộ
In Silico Analysis for Determination and Validation of Human CD20 Antigen 3D Structure
Springer Science and Business Media LLC - Tập 25 - Trang 123-135 - 2017
Zahra Payandeh, Masoumeh Rajabibazl, Yousef Mortazavi, Azam Rahimpour
CD20 has been known as an attractive therapeutic target for refractory diseases such as B-cell chronic lymphocytic leukemia, rheumatoid arthritis and multiple sclerosis. Determining the 3D structure of the CD20 antigen could help to achieve a better deduction of its functions and its interactions with ligands. In this regard, we have launched an in silico protein modeling strategy to unveil the pr... hiện toàn bộ
Application of Antimicrobial Peptides in the Design and Production of Anticancer Agents
Springer Science and Business Media LLC -
Bahareh Vakili, Ali Jahanian-Najafabadi
Solid Phase Synthesis of a Hydroxypyrrolidine Derivative and its Use in Solid Phase Peptide Synthesis as Constrained Statine Mimic
Springer Science and Business Media LLC - Tập 13 - Trang 337-343 - 2007
Pascal Verdié, Gilles Subra, Pierre Chevallet, Muriel Amblard, Jean Martinez
As part of our efforts to design constrained peptide mimics and introduce them in peptide sequences, we set up the synthesis of racemic N-Fmoc protected hydroxypyrrolidine by reduction of the corresponding oxopyrroline. Hydroxypyrrolidines are synthesized using amino acid building block and β-ketoester via a 4-steps solid supported route on Wang resin beads. The hydroxypyrrolidine template can be ... hiện toàn bộ
Đánh giá các đặc tính chức năng của protein thủy phân từ mầm lúa mì và tác động của nó đến các đặc tính vật lý - hóa học của sữa chua đông lạnh Dịch bởi AI
Springer Science and Business Media LLC - Tập 28 Số 2 - Trang 1-12 - 2022
Ghelich, Sekineh, Ariaii, Peiman, Ahmadi, Mohammad
Trong nghiên cứu này, tác động của protein thủy phân từ mầm lúa mì (WGPH) lên các đặc tính vật lý - hóa học và cảm quan của sữa chua đông lạnh đã được điều tra. Để thực hiện điều này, trước tiên, WGPH được sản xuất bằng cách sử dụng hai enzyme, alcalase và flavourzyme, và các đặc tính chức năng của nó đã được xác định để tìm ra enzyme tối ưu. Sau đó, 4 loại sữa chua đông lạnh được chuẩn bị, bao gồ... hiện toàn bộ
#WGPH #protein thủy phân #mầm lúa mì #sữa chua đông lạnh #đặc tính vật lý - hóa học #enzyme alcalase #cảm quan
A 12-Crown-4 Ether Containing Dipeptide Boc-12-Crown-4-l-DOPA-Gly-OMe Induces Cell Cycle Arrest and Apoptosis in Rat Eggs Cultured In Vitro
Springer Science and Business Media LLC - Tập 22 - Trang 57-66 - 2015
Garima Tripathi, Anima Tripathi, Gurunath Ramanathan, Shail K. Chaube
The study was designed to investigate whether crown ether containing dipeptide Boc-12-crown-4-l-DOPA-Gly-OMe has potential to induce meiotic cell cycle arrest and apoptosis in rat eggs cultured in vitro. The immature female rats were subjected to superovulation induction protocol and ovulated eggs were collected from ampulla of the fallopian tube. Ovulated eggs arrested at metaphase-II (M-II) stag... hiện toàn bộ
Variants of Lipopeptides Produced by Bacillus licheniformis HSN221 in Different Medium Components Evaluated by a Rapid Method ESI-MS
Springer Science and Business Media LLC - Tập 14 - Trang 229-235 - 2008
Yi-Ming Li, Namir I. A. Haddad, Shi-Zhong Yang, Bo-Zhong Mu
A lipopeptide producing strain was isolated from an oil field and identified as Bacillus licheniformis HSN221. Nine different substrates were used to cultivate the strain under the same incubation conditions. Using a rapid method, Electrospray Ionization Mass Spectrometry (ESI-MS) combined with Thin Layer Chromatography (TLC), nine different lipopeptide homologues were found and identified. The st... hiện toàn bộ
Synthetic peptides induce antibodies in sheep againstTaenia ovis
Springer Science and Business Media LLC - - 1999
Davina Dadley-Moore, Marshall W. Lightowlers, Charles G. Gauci, J.S. Rothel, David C. Jackson
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