Flower-like PEGylated MoS2 nanoflakes for near-infrared photothermal cancer therapyScientific Reports - Tập 5 Số 1
Wei Feng, Liang Chen, Ming Qin, Xiaojun Zhou, Qianqian Zhang, Yingke Miao, Kexin Qiu, Yanzhong Zhang, Chuanglong He
AbstractPhotothermal cancer therapy has attracted considerable interest for cancer treatment in recent years, but the effective photothermal agents remain to be explored before this strategy can be applied clinically. In this study, we therefore develop flower-like molybdenum disulfide (MoS2) nanoflakes and investigate their potential for photo...... hiện toàn bộ
Cancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and finding synergistic drug combinationsScientific Reports - Tập 8 Số 1
Julia A. Yaglom, Yongmei Wang, Amy Li, Zhenghu Li, Stefano Monti, Ilya Alexandrov, Xiongbin Lu, Michael Y. Sherman
AbstractHsp70 is a promising anti-cancer target. Our JG-98 series of Hsp70 inhibitors show anti-cancer activities affecting both cancer cells and tumor-associated macrophages. They disrupt Hsp70 interaction with a co-chaperone Bag3 and affect signaling pathways important for cancer development. Due to a prior report that depletion of Hsp70 causes similar responses ...... hiện toàn bộ
Numerical study of bio-convection flow of magneto-cross nanofluid containing gyrotactic microorganisms with activation energyScientific Reports - Tập 11 Số 1
Qiu‐Hong Shi, Aamir Hamid, M. Ijaz Khan, R. Naveen Kumar, R. J. Punith Gowda, B. C. Prasannakumara, Nehad Ali Shah, Sami Ullah Khan, Jae Dong Chung
AbstractIn this study, a mathematical model is developed to scrutinize the transient magnetic flow of Cross nanoliquid past a stretching sheet with thermal radiation effects. Binary chemical reactions and heat source/sink effects along with convective boundary condition are also taken into the consideration. Appropriate similarity transformations are utilized to tr...... hiện toàn bộ
A rapid-screening approach to detect and quantify microplastics based on fluorescent tagging with Nile RedScientific Reports - Tập 7 Số 1
Thomas Maes, Rebecca Jessop, Nikolaus Wellner, Karsten Haupt, Andrew G. Mayes
AbstractA new approach is presented for analysis of microplastics in environmental samples, based on selective fluorescent staining using Nile Red (NR), followed by density-based extraction and filtration. The dye adsorbs onto plastic surfaces and renders them fluorescent when irradiated with blue light. Fluorescence emission is detected using simple photography th...... hiện toàn bộ
Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in miceScientific Reports - Tập 7 Số 1
Wenliang Zhang, Wei Zhong, Qian Sun, Xinguo Sun, Zhanxiang Zhou
AbstractChronic alcohol feeding causes lipid accumulation and apoptosis in the liver. This study investigated the role of bioactive lipid metabolites in alcohol-induced liver damage and tested the potential of targeting arachidonate 15-lipoxygenase (ALOX15) in treating alcoholic liver disease (ALD). Results showed that chronic alcohol exposure induced hepatocyte ap...... hiện toàn bộ
HIV-1 proteins dysregulate motivational processes and dopamine circuitryScientific Reports - Tập 8 Số 1
Sarah J. Bertrand, Charles F. Mactutus, Steven B. Harrod, Landhing M. Moran, Rosemarie M. Booze
AbstractMotivational alterations, such as apathy, in HIV-1+ individuals are associated with decreased performance on tasks involving frontal-subcortical circuitry. We used the HIV-1 transgenic (Tg) rat to assess effect of long-term HIV-1 protein exposure on motivated behavior using sucrose (1–30%, w/v) and cocaine (0.01–1.0 mg/kg/infusion) maintained responding wit...... hiện toàn bộ