Scientific Reports

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
Superoxide dismutase 2 knockdown leads to defects in locomotor activity, sensitivity to paraquat, and increased cuticle pigmentation in Tribolium castaneum
Scientific Reports - Tập 6 Số 1
Hiroko Tabunoki, Maureen J. Gorman, Neal T. Dittmer, Michael R. Kanost
AbstractInsects can rapidly adapt to environmental changes through physiological responses. The red flour beetle Tribolium castaneum is widely used as a model insect species. However, the stress–response system of this species remains unclear. Superoxide dismutase 2 (SOD2) is a crucial antioxidative enzyme that is found in mitochondria. <...... hiện toàn bộ
MicroRNA-mediated mRNA Translation Activation in Quiescent Cells and Oocytes Involves Recruitment of a Nuclear microRNP
Scientific Reports - Tập 2 Số 1
Samuel S. Truesdell, Richard D. Mortensen, Mihwa Seo, Joshua Schroeder, J. H. Lee, Olivier Letonqueze, Shobha Vasudevan
Three-dimensional Nitrogen-Doped Graphene Supported Molybdenum Disulfide Nanoparticles as an Advanced Catalyst for Hydrogen Evolution Reaction
Scientific Reports - Tập 5 Số 1
Haifeng Dong, Conghui Liu, Haitao Ye, Linping Hu, Bunshi Fugetsu, Wenhao Dai, Yu Cao, Xueqiang Qi, Huiting Lu, Xueji Zhang
AbstractAn efficient three-dimensional (3D) hybrid material of nitrogen-doped graphene sheets (N-RGO) supporting molybdenum disulfide (MoS2) nanoparticles with high-performance electrocatalytic activity for hydrogen evolution reaction (HER) is fabricated by using a facile hydrothermal route. Comprehensive microscopic and spectroscopic character...... hiện toàn bộ
Flower-like PEGylated MoS2 nanoflakes for near-infrared photothermal cancer therapy
Scientific Reports - Tập 5 Số 1
Wei Feng, Liang Chen, Ming Qin, Xiaojun Zhou, Qianqian Zhang, Yingke Miao, Kexin Qiu, Yanzhong Zhang, Chuanglong He
AbstractPhotothermal cancer therapy has attracted considerable interest for cancer treatment in recent years, but the effective photothermal agents remain to be explored before this strategy can be applied clinically. In this study, we therefore develop flower-like molybdenum disulfide (MoS2) nanoflakes and investigate their potential for photo...... hiện toàn bộ
Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis
Scientific Reports - Tập 9 Số 1
Justin E. Ideozu, Xi Zhang, Vittobai Rashika Rangaraj, Susanna A. McColley, Hara Levy
AbstractExtracellular circulating miRNAs (ECmiRNAs) play a crucial role in cell-to-cell communication and serve as non-invasive biomarkers in a wide range of diseases, but their abundance and functional relevance in cystic fibrosis (CF) remain poorly understood. In this study, we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF ...... hiện toàn bộ
Colorectal cancer characterization and therapeutic target prediction based on microRNA expression profile
Scientific Reports - Tập 6 Số 1
Peng Xu, Yanliang Zhu, Bo Sun, Zhongdang Xiao
AbstractColorectal cancer (CRC) is one of the most commonly diagnosed cancers and a major cause of cancer death. However, the molecular mechanisms underlying CRC initiation, growth and metastasis are poorly understood. In this study, based on our previous work for comprehensively analyzing miRNA sequencing data, we examined a series of colorectal cancer microRNAs e...... hiện toàn bộ
The anti-tumor activities of Neferine on cell invasion and oxaliplatin sensitivity regulated by EMT via Snail signaling in hepatocellular carcinoma
Scientific Reports - Tập 7 Số 1
Geng Deng, Shan Zeng, Junli Ma, Yan Zhang, Yanling Qu, Ying Han, Ling Yin, Changjing Cai, Cao Guo, Hong Shen
AbstractTumor invasion and chemotherapy resistance, which are associated with epithelial-mesenchymal transition (EMT), remain as major challenges in hepatocellular carcinoma (HCC) treatment. Neferine, a natural component of Nelumbo nucifera, have been proven the antitumor efficiency in cancer, but the effects of Neferine on HCC invasion and chemosensitivity need to...... hiện toàn bộ
Polydatin inhibits mast cell-mediated allergic inflammation by targeting PI3K/Akt, MAPK, NF-κB and Nrf2/HO-1 pathways
Scientific Reports - Tập 7 Số 1
Jing Ye, Hongmei Piao, Jingzhi Jiang, Guangyu Jin, Mingyu Zheng, Jinshi Yang, Xiang Jin, Tianyi Sun, Yun Ho Choi, Liangchang Li, Guanghai Yan
AbstractPolydatin(PD) shows anti-allergic inflammatory effect, and this study investigated its underlying mechanisms inin vitroandin vivomodels. IgE-mediated passive cutaneous anaphylaxis (PCA) and passive systemic anaphylaxis (PSA) models were used to confirm PD effectin vivo. Various...... hiện toàn bộ
Hsp70-containing extracellular vesicles are capable of activating of adaptive immunity in models of mouse melanoma and colon carcinoma
Scientific Reports - Tập 11 Số 1
Elena Y. Komarova, Роман В. Суезов, Alina D. Nikotina, Nikolay Aksenov, Luiza Garaeva, Tatiana Shtam, A. Zhakhov, Marina G. Martynova, А. В. Добродумов, Maria Istomina, A. Ischenko, Boris A. Margulis, Irina V. Guzhova
AbstractThe release of Hsp70 chaperone from tumor cells is found to trigger the full-scale anti-cancer immune response. Such release and the proper immune reaction can be induced by the delivery of recombinant Hsp70 to a tumor and we sought to explore how the endogenous Hsp70 can be transported to extracellular space leading to the burst of anti-cancer activity. Hs...... hiện toàn bộ
Synergistic effect of cisplatin chemotherapy combined with fractionated radiotherapy regimen in HPV-positive and HPV-negative experimental pharyngeal squamous cell carcinoma
Scientific Reports - Tập 10 Số 1
Simona Kranjc, Ajda Prevc, Martina Nikšić Žakelj, Andreja Brožič, Maja Čemažar, Primož Strojan, Gregor Serša
AbstractHPV infection renders oropharyngeal squamous cell carcinomas more radiosensitive, which results in a favorable prognosis for HPV-positive patients treated with radiation alone or with concurrent platinum-based chemotherapy. The degree of radiosensitivity in fractionated regimens has not yet been fully explored; therefore, in this study, the radiosensitivity...... hiện toàn bộ
Tổng số: 2,064   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 10