Scientific Reports
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
Superoxide dismutase 2 knockdown leads to defects in locomotor activity, sensitivity to paraquat, and increased cuticle pigmentation in Tribolium castaneum
Scientific Reports - Tập 6 Số 1
AbstractInsects can rapidly adapt to environmental changes through physiological
responses. The red flour beetle Tribolium castaneum is widely used as a model
insect species. However, the stress–response system of this species remains
unclear. Superoxide dismutase 2 (SOD2) is a crucial antioxidative enzyme that is
found in mitochondria. T. castaneum SOD2 (TcSOD2) is composed of 215 amino
acids, an...
MicroRNA-mediated mRNA Translation Activation in Quiescent Cells and Oocytes Involves Recruitment of a Nuclear microRNP
Scientific Reports - Tập 2 Số 1
Three-dimensional Nitrogen-Doped Graphene Supported Molybdenum Disulfide Nanoparticles as an Advanced Catalyst for Hydrogen Evolution Reaction
Scientific Reports - Tập 5 Số 1
AbstractAn efficient three-dimensional (3D) hybrid material of nitrogen-doped
graphene sheets (N-RGO) supporting molybdenum disulfide (MoS2) nanoparticles
with high-performance electrocatalytic activity for hydrogen evolution reaction
(HER) is fabricated by using a facile hydrothermal route. Comprehensive
microscopic and spectroscopic characterizations confirm the resulting hybrid
material possess...
Flower-like PEGylated MoS2 nanoflakes for near-infrared photothermal cancer therapy
Scientific Reports - Tập 5 Số 1
AbstractPhotothermal cancer therapy has attracted considerable interest for
cancer treatment in recent years, but the effective photothermal agents remain
to be explored before this strategy can be applied clinically. In this study, we
therefore develop flower-like molybdenum disulfide (MoS2) nanoflakes and
investigate their potential for photothermal ablation of cancer cells. MoS2
nanoflakes are ...
Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis
Scientific Reports - Tập 9 Số 1
AbstractExtracellular circulating miRNAs (ECmiRNAs) play a crucial role in
cell-to-cell communication and serve as non-invasive biomarkers in a wide range
of diseases, but their abundance and functional relevance in cystic fibrosis
(CF) remain poorly understood. In this study, we employed microarray technology
to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the
functional rele...
Colorectal cancer characterization and therapeutic target prediction based on microRNA expression profile
Scientific Reports - Tập 6 Số 1
AbstractColorectal cancer (CRC) is one of the most commonly diagnosed cancers
and a major cause of cancer death. However, the molecular mechanisms underlying
CRC initiation, growth and metastasis are poorly understood. In this study,
based on our previous work for comprehensively analyzing miRNA sequencing data,
we examined a series of colorectal cancer microRNAs expression profiles data.
Results ...
The anti-tumor activities of Neferine on cell invasion and oxaliplatin sensitivity regulated by EMT via Snail signaling in hepatocellular carcinoma
Scientific Reports - Tập 7 Số 1
AbstractTumor invasion and chemotherapy resistance, which are associated with
epithelial-mesenchymal transition (EMT), remain as major challenges in
hepatocellular carcinoma (HCC) treatment. Neferine, a natural component of
Nelumbo nucifera, have been proven the antitumor efficiency in cancer, but the
effects of Neferine on HCC invasion and chemosensitivity need to be elucidated.
Applying multiple...
Polydatin inhibits mast cell-mediated allergic inflammation by targeting PI3K/Akt, MAPK, NF-κB and Nrf2/HO-1 pathways
Scientific Reports - Tập 7 Số 1
AbstractPolydatin(PD) shows anti-allergic inflammatory effect, and this study
investigated its underlying mechanisms inin vitroandin vivomodels. IgE-mediated
passive cutaneous anaphylaxis (PCA) and passive systemic anaphylaxis (PSA)
models were used to confirm PD effectin vivo. Various signaling pathway proteins
in mast cell were examined. RT-PCR, ELISA and western blotting were applied when
appro...
Hsp70-containing extracellular vesicles are capable of activating of adaptive immunity in models of mouse melanoma and colon carcinoma
Scientific Reports - Tập 11 Số 1
AbstractThe release of Hsp70 chaperone from tumor cells is found to trigger the
full-scale anti-cancer immune response. Such release and the proper immune
reaction can be induced by the delivery of recombinant Hsp70 to a tumor and we
sought to explore how the endogenous Hsp70 can be transported to extracellular
space leading to the burst of anti-cancer activity. Hsp70 transport mechanisms
were stu...
Synergistic effect of cisplatin chemotherapy combined with fractionated radiotherapy regimen in HPV-positive and HPV-negative experimental pharyngeal squamous cell carcinoma
Scientific Reports - Tập 10 Số 1
AbstractHPV infection renders oropharyngeal squamous cell carcinomas more
radiosensitive, which results in a favorable prognosis for HPV-positive patients
treated with radiation alone or with concurrent platinum-based chemotherapy. The
degree of radiosensitivity in fractionated regimens has not yet been fully
explored; therefore, in this study, the radiosensitivity of HPV-negative tumors
(FaDu) wa...
Tổng số: 2,064
- 1
- 2
- 3
- 4
- 5
- 6
- 10