Scientific Reports

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Superoxide dismutase 2 knockdown leads to defects in locomotor activity, sensitivity to paraquat, and increased cuticle pigmentation in Tribolium castaneum
Scientific Reports - Tập 6 Số 1
Hiroko Tabunoki, Maureen J. Gorman, Neal T. Dittmer, Michael R. Kanost
AbstractInsects can rapidly adapt to environmental changes through physiological responses. The red flour beetle Tribolium castaneum is widely used as a model insect species. However, the stress–response system of this species remains unclear. Superoxide dismutase 2 (SOD2) is a crucial antioxidative enzyme that is found in mitochondria. <...... hiện toàn bộ
MicroRNA-mediated mRNA Translation Activation in Quiescent Cells and Oocytes Involves Recruitment of a Nuclear microRNP
Scientific Reports - Tập 2 Số 1
Samuel S. Truesdell, Richard D. Mortensen, Mihwa Seo, Joshua Schroeder, J. H. Lee, Olivier Letonqueze, Shobha Vasudevan
Three-dimensional Nitrogen-Doped Graphene Supported Molybdenum Disulfide Nanoparticles as an Advanced Catalyst for Hydrogen Evolution Reaction
Scientific Reports - Tập 5 Số 1
Haifeng Dong, Conghui Liu, Haitao Ye, Linping Hu, Bunshi Fugetsu, Wenhao Dai, Yu Cao, Xueqiang Qi, Huiting Lu, Xueji Zhang
AbstractAn efficient three-dimensional (3D) hybrid material of nitrogen-doped graphene sheets (N-RGO) supporting molybdenum disulfide (MoS2) nanoparticles with high-performance electrocatalytic activity for hydrogen evolution reaction (HER) is fabricated by using a facile hydrothermal route. Comprehensive microscopic and spectroscopic character...... hiện toàn bộ
Flower-like PEGylated MoS2 nanoflakes for near-infrared photothermal cancer therapy
Scientific Reports - Tập 5 Số 1
Wei Feng, Liang Chen, Ming Qin, Xiaojun Zhou, Qianqian Zhang, Yingke Miao, Kexin Qiu, Yanzhong Zhang, Chuanglong He
AbstractPhotothermal cancer therapy has attracted considerable interest for cancer treatment in recent years, but the effective photothermal agents remain to be explored before this strategy can be applied clinically. In this study, we therefore develop flower-like molybdenum disulfide (MoS2) nanoflakes and investigate their potential for photo...... hiện toàn bộ
Colorectal cancer characterization and therapeutic target prediction based on microRNA expression profile
Scientific Reports - Tập 6 Số 1
Peng Xu, Yanliang Zhu, Bo Sun, Zhongdang Xiao
AbstractColorectal cancer (CRC) is one of the most commonly diagnosed cancers and a major cause of cancer death. However, the molecular mechanisms underlying CRC initiation, growth and metastasis are poorly understood. In this study, based on our previous work for comprehensively analyzing miRNA sequencing data, we examined a series of colorectal cancer microRNAs e...... hiện toàn bộ
Polydatin inhibits mast cell-mediated allergic inflammation by targeting PI3K/Akt, MAPK, NF-κB and Nrf2/HO-1 pathways
Scientific Reports - Tập 7 Số 1
Jing Ye, Hongmei Piao, Jingzhi Jiang, Guangyu Jin, Mingyu Zheng, Jinshi Yang, Xiang Jin, Tianyi Sun, Yun Ho Choi, Liangchang Li, Guanghai Yan
AbstractPolydatin(PD) shows anti-allergic inflammatory effect, and this study investigated its underlying mechanisms inin vitroandin vivomodels. IgE-mediated passive cutaneous anaphylaxis (PCA) and passive systemic anaphylaxis (PSA) models were used to confirm PD effectin vivo. Various...... hiện toàn bộ
Hsp70-containing extracellular vesicles are capable of activating of adaptive immunity in models of mouse melanoma and colon carcinoma
Scientific Reports - Tập 11 Số 1
Elena Y. Komarova, Роман В. Суезов, Alina D. Nikotina, Nikolay Aksenov, Luiza Garaeva, Tatiana Shtam, A. Zhakhov, Marina G. Martynova, А. В. Добродумов, Maria Istomina, A. Ischenko, Boris A. Margulis, Irina V. Guzhova
AbstractThe release of Hsp70 chaperone from tumor cells is found to trigger the full-scale anti-cancer immune response. Such release and the proper immune reaction can be induced by the delivery of recombinant Hsp70 to a tumor and we sought to explore how the endogenous Hsp70 can be transported to extracellular space leading to the burst of anti-cancer activity. Hs...... hiện toàn bộ
Cancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and finding synergistic drug combinations
Scientific Reports - Tập 8 Số 1
Julia A. Yaglom, Yongmei Wang, Amy Li, Zhenghu Li, Stefano Monti, Ilya Alexandrov, Xiongbin Lu, Michael Y. Sherman
AbstractHsp70 is a promising anti-cancer target. Our JG-98 series of Hsp70 inhibitors show anti-cancer activities affecting both cancer cells and tumor-associated macrophages. They disrupt Hsp70 interaction with a co-chaperone Bag3 and affect signaling pathways important for cancer development. Due to a prior report that depletion of Hsp70 causes similar responses ...... hiện toàn bộ
Numerical study of bio-convection flow of magneto-cross nanofluid containing gyrotactic microorganisms with activation energy
Scientific Reports - Tập 11 Số 1
Qiu‐Hong Shi, Aamir Hamid, M. Ijaz Khan, R. Naveen Kumar, R. J. Punith Gowda, B. C. Prasannakumara, Nehad Ali Shah, Sami Ullah Khan, Jae Dong Chung
AbstractIn this study, a mathematical model is developed to scrutinize the transient magnetic flow of Cross nanoliquid past a stretching sheet with thermal radiation effects. Binary chemical reactions and heat source/sink effects along with convective boundary condition are also taken into the consideration. Appropriate similarity transformations are utilized to tr...... hiện toàn bộ
A rapid-screening approach to detect and quantify microplastics based on fluorescent tagging with Nile Red
Scientific Reports - Tập 7 Số 1
Thomas Maes, Rebecca Jessop, Nikolaus Wellner, Karsten Haupt, Andrew G. Mayes
AbstractA new approach is presented for analysis of microplastics in environmental samples, based on selective fluorescent staining using Nile Red (NR), followed by density-based extraction and filtration. The dye adsorbs onto plastic surfaces and renders them fluorescent when irradiated with blue light. Fluorescence emission is detected using simple photography th...... hiện toàn bộ
Tổng số: 2,064   
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