Science in China Series B: Chemistry
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Study on the drug resistance and the binding mode of HIV-1 integrase with LCA inhibitor
Science in China Series B: Chemistry - Tập 50 - Trang 665-674 - 2007
Human immunodeficiency virus type 1 (HIV-1) integrase (IN) is an essential enzyme in the lifecycle of this virus and also an important target for the study of anti-HIV drugs. The binding mode of the wild type IN core domain and its G140S mutant with L-Chicoric acid (LCA) inhibitor were investigated by using multiple conformation molecular docking and molecular dynamics (MD) simulation. Based on th...... hiện toàn bộ
High-generation organometallic rotaxane dendrimer
Science in China Series B: Chemistry - Tập 58 - Trang 1089-1089 - 2015
Morphology and modulus evolution of graphite anode in lithium ion battery: An in situ AFM investigation
Science in China Series B: Chemistry - Tập 57 Số 1 - Trang 178-183 - 2014
Synthesis and characterization of a pH-sensitive shielding system for polycation gene carriers
Science in China Series B: Chemistry - Tập 53 - Trang 502-507 - 2010
To increase the in vivo stability of polycation gene carriers, a pH-sensitive shielding system, γ-benzyl l-glutamate-co-glutamate acid polymer (PGA(60) (60 refers to the molar ratio of glutamate acid in the polymer)), was synthesized and characterized. PGA(60) showed pH sensitivity at about pH 6.0. PGA(60) shielded the positive charge of DNA/PEI (1:1) complexes. Gel retardation assay showed that n...... hiện toàn bộ
Engineering molecular self-assembly of theranostic nanoprobes for dual-modal imaging-guided precise chemotherapy
Science in China Series B: Chemistry - Tập 64 - Trang 2045-2052 - 2021
Uniting dual-modality of fluorescence and photoacoustic (PA) imaging into theranostic nanoprobes is imperative for spatio-temporally tracking of drug delivery, distribution, and release. Herein, we present a rational design strategy of molecularly precise amphiphilic prodrugs BPn-Cy-S-CPT (n=0, 5, and 20, refers to the degree of polyethylene glycol (PEG) polymerization; CPT=camptothecin) to tune t...... hiện toàn bộ
Preorganization boosts the artificial esterase activity of a self-assembling peptide
Science in China Series B: Chemistry - Tập 64 - Trang 1554-1559 - 2021
The creation of artificial enzymes to mimic natural enzymes remains a great challenge owing to the complexity of the structural arrangement of the essential amino acids in catalytic centers. In this study, we used the phosphatase-based enzyme-instructed self-assembly (EISA) to supervise artificial esterases’ final structures and catalytic activities. We reported that peptide precursors containing ...... hiện toàn bộ
A microchip to analyze single crystal growth and size-controllability
Science in China Series B: Chemistry - Tập 52 - Trang 1014-1020 - 2009
A microfluidic device to control single crystallization on the micron scale has been developed. The salt solution was stored in the nano-volume gaps between the arrays of protrudent circular plots in the microchip. The mixed organic solvent was injected into the chip as the counter diffusion phase for crystallization forming. This device provides a liquid-liquid interface through which only one ph...... hiện toàn bộ
Asymmetric catalytic 1,3-dipolar cycloaddition of α-diazoesters for synthesis of 1-pyrazoline-based spirochromanones and beyond
Science in China Series B: Chemistry - Tập 64 - Trang 1355-1360 - 2021
A highly enantioselective 1,3-dipolar cycloaddition of α-substituted diazoesters with exocyclic enones was achieved with chiral scandium(III)/N,N’-dioxide complex as the catalyst. This protocol provided a facile and efficient route to optically active 1-pyrazoline-based spirochromanones and others with good outcomes (up to 97% yield, 98% ee with >95:5 dr). Moreover, enantioenriched 2-pyrazoline-ba...... hiện toàn bộ
Divalent anion intercalation and etching-hydrolysis strategies to construct ultra-stable electrodes for seawater splitting
Science in China Series B: Chemistry - - Trang 1-9 - 2023
Developing stable electrodes for seawater splitting remains a great challenge due to the detachment of catalysts at a large operating current and severe anode corrosion caused by chlorine. Herein, divalent anion intercalation and etching-hydrolysis strategies are deployed to synthesize the ultra-stable anode, dendritic Fe(OH)3 grown on Ni(SO4)0.3(OH)1.4-Ni(OH)2. Experimental results reveal that th...... hiện toàn bộ
Analysis of receptor-ligand binding by photoaffinity cross-linking
Science in China Series B: Chemistry - Tập 57 Số 2 - Trang 232-242 - 2014
Tổng số: 3,565
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