Revista Brasileira de Farmacognosia
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Growth inhibition of human breast cancer cells and down-regulation of ODC1 and ADA genes by Nepeta binaloudensis
Revista Brasileira de Farmacognosia - Tập 27 - Trang 84-90 - 2016
Nepeta binaloudensis Jamzad, Lamiaceae, is a rare medicinal plant endemic to Iran. In spite of many studies about the chemical constituents and antibacterial effects of this species, no report has been provided about its cytotoxic and anticancer activities. In this study we have evaluated the effects of EtOH 70%, hexane and aqueous extracts of N. binaloudensis on the cell proliferation and n-hexan......
Cardiac glycosides from Cascabela thevetioides by HPLC-MS analysis
Revista Brasileira de Farmacognosia - Tập 29 - Trang 441-444 - 2019
The present work investigates the chemical composition of seeds of Cascabela thevetioides (Kunth) Lip-pold, an ornamental shrub of México. Six thevetia cardiac glycosides or thevetosides (thevetin A, B, and C, acetylthevetin A, B and C) were identified from the methanol extract of seeds of C. thevetioides by High-Performance Liquid Chromatography-Mass Spectrometry and by comparison of mass spectra......
Dehydroandrographolide Improvement of Acetaminophen-Induced Acute Liver Failure
Revista Brasileira de Farmacognosia - Tập 33 - Trang 523-533 - 2023
Acetaminophen-induced drug-induced acute liver injury is a liver disease which is one of the most serious human health diseases. Dehydroandrographolide is a natural product found in Andrographis paniculata (Burm.f.) Wall., Acanthaceae, with therapeutical uses such as analgesic and hepatoprotective. The present study was designed to analyze the effect of dehydroandrographolide on acetaminophen-indu......
Inhibitory Effects and Related Molecular Mechanisms of Huanglian-Ganjiang Combination Against H1N1 Influenza Virus
Revista Brasileira de Farmacognosia - Tập 33 - Trang 514-522 - 2023
Influenza is an infectious acute respiratory disease with complications and a high mortality rate; the effective medicines for influenza therapy are limited. “Huanglian” or Coptidis Rhizoma, Coptis chinensis Franch., Ranunculaceae, and “ganjiang” or Zingiberis Rhizoma, Zingiber officinale Roscoe, Zingiberaceae, combination is clinically used for treating respiratory diseases. HPLC was applied for ......
Comparative Dose- and Time-Dependent Manner of Resveratrol on Human Epithelial Cell Types
Revista Brasileira de Farmacognosia - Tập 32 - Trang 466-471 - 2022
Resveratrol is a conventional nutraceutical compound that has been extensively studied for therapeutic applications, especially cancer therapy; however, its positive therapeutical proprieties are balanced by its negative effects. Presently, the therapeutic functionalities of resveratrol for nasopharyngeal carcinoma, osteosarcoma, and human embryonic cell lines, in terms of optimum dose and time pr......
Validation of Anti-pyretic-Derived Natural Products and Their Potentials for Drug Discovery
Revista Brasileira de Farmacognosia - Tập 33 - Trang 696-712 - 2023
Fever is a complicated process
that occurs in response to infection and inflammatory diseases, stimulating the immune system that may cause severe biological changes in the human body. Hence, anti-pyretic agents are prescribed to reduce elevated body temperature in order to maintain thermal homeostasis and protect the brain from damage. Additionally, there is always a growing need for safe and eff......
Aspidosperma subincanum II. Usefulness of uleine and ribonucleic fragments in the treatment of AIDS patients
Revista Brasileira de Farmacognosia - Tập 25 - Trang 42-46 - 2015
Aids patients were treated during a year with three different food supplements commercially avail-able: para-pau-aspido (Aspidospermasubincanum Mart. ex A. DC, Apocynaceae); 2Leid (nucleic acids and cytokines); and Para Immuno (propolis, pollen and royal jelly). All foods, given either alone or in com-bination, proved useful to all AIDS patients who received the supplements, be these under trither......
Sesquiterpene Coumarins from Ferula narthex 15-LOX, α-Glucosidase Inhibition and Molecular Docking Studies
Revista Brasileira de Farmacognosia - Tập 30 - Trang 12-17 - 2020
Ferula narthex Boiss., Apiaceae, is commonly used in Pakistan and India as spice and it is associated with diverse biological activities including antidiabetic and anti-inflammatory. Research has suggested that the genus Ferula is rich in sesquiterpene coumarins. During this project, both in vitro and in silico models were adopted to investigate its traditional use. Based on structural diversity, ......
Diosmetin Alleviates Ovalbumin-Induced Nasal Inflammation by Regulating the SIRT1/NF-κB Signaling in Mouse Models of Allergic Rhinitis
Revista Brasileira de Farmacognosia - Tập 33 - Trang 1232-1242 - 2023
Diosmetin is a flavonoid compound with various pharmacological activities, which plays a vital role in alleviating the development of asthma and atopic dermatitis. However, the role of diosmetin in allergic rhinitis is unclear. Our study aimed to investigate the effects of diosmetin on AR progression and the underlying molecular mechanisms. The allergic rhinitis murine model was established via ov......
Leaf venation pattern to recognize austral South American medicinal species of “cow's hoof” ( Bauhinia L., Fabaceae)
Revista Brasileira de Farmacognosia - Tập 27 - Trang 158-161 - 2017
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