A cytotoxic Petiveria alliacea dry extract induces ATP depletion and decreases β-F1-ATPase expression in breast cancer cells and promotes survival in tumor-bearing mice

Acebo, 2009, Cancer abolishes the tissue type-specific differences in the phenotype of energetic metabolism, Transl. Oncol., 2, 138, 10.1593/tlo.09106 Chen, 2012, Bezielle selectively targets mitochondria of cancer cells to inhibit glycolysis and OXPHOS, PLoS ONE, 7, e30300, 10.1371/journal.pone.0030300 Chirinos, 1992 Ciavardelli, 2014, Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment, Cell Death Dis., 5, e1336, 10.1038/cddis.2014.285 Cifuentes, 2009, A fraction from Petiveria alliacea induces apoptosis via a mitochondria dependent pathway and regulates Hsp70 expression, Universitas Sci., 14, 125, 10.11144/javeriana.SC14-2-3.affp Correa, 1998 Cuezva, 2002, The bioenergetic signature of cancer: a marker of tumor progression, Cancer Res., 62, 6674 Cuezva, 2009, The tumor suppressor function of mitochondria: translation into the clinics, Biochim. Biophys. Acta, 1792, 1145, 10.1016/j.bbadis.2009.01.006 Fantin, 2006, Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance, Cancer Cell, 9, 425, 10.1016/j.ccr.2006.04.023 Formentini, 2010, The mitochondrial bioenergetic capacity of carcinomas, IUBMB Life, 62, 554, 10.1002/iub.352 Garcia-Barriga, 1974 Gledhill, 2007, Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols, PNAS, 104, 13632, 10.1073/pnas.0706290104 Gong, 2013, Beclin 1 and autophagy are required for the tumorigenicity of breast cancer stem-like/progenitor cells, Oncogene, 32, 2261, 10.1038/onc.2012.252 Govindarajan, 2007, Overexpression of Akt converts radial growth melanoma to vertical growth melanoma, J. Clin. Invest., 117, 719, 10.1172/JCI30102 Gupta, 1995 Hernandez, 2014, A Petiveria alliacea standardized fraction induces breast adenocarcinoma cell death by modulating glycolytic metabolism, J. Ethnopharmacol., 153, 641, 10.1016/j.jep.2014.03.013 Jose, 2013, Rationale for mitochondria-targeting strategies in cancer bioenergetic therapies, Int. J. Biochem. Cell Biol., 45, 123, 10.1016/j.biocel.2012.07.005 Koukourakis, 2008, Serum and tissue LDH levels in patients with breast/gynaecological cancer and benign diseases, Gynecol. Obstet. Invest., 67, 162, 10.1159/000183250 Leist, 1997, Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis, J. Exp. Med., 185, 1481, 10.1084/jem.185.8.1481 Morales, 2001, Preliminary screening of five ethnomedicinal plants of Guatemala, Farmaco, 56, 523, 10.1016/S0014-827X(01)01107-7 Nanni, 1983, TS/A: a new metastasizing cell line from a BALB/c spontaneous mammary adenocarcinoma, Clin. Exp. Metastasis, 1, 373, 10.1007/BF00121199 Pampaloni, 2007, The third dimension bridges the gap between cell culture and live tissue, Nat. Rev. Mol. Cell Biol., 8, 839, 10.1038/nrm2236 Papandreou, 2011, Anticancer drugs that target metabolism: is dichloroacetate the new paradigm?, Int. J. Cancer, 128, 1001, 10.1002/ijc.25728 Rossi, 1990, Antiproliferative effects of Petiveria alliacea on several tumoral lines, Pharmacol. Res., 22, 434, 10.1016/S1043-6618(09)80443-X Rossi, 1993, Effects of Petiveria alliacea L. on cell immunity, Pharmacol. Res., 27, 111, 10.1006/phrs.1993.1090 Stock, 1999, Molecular architecture of the rotary motor in ATP synthase, Science, 286, 1700, 10.1126/science.286.5445.1700 Suolinna, 1975, The effect of flavonoids on aerobic glycolysis and growth of tumor cells, Cancer Res., 35, 1865 Urueña, 2008, Petiveria alliacea extracts uses multiple mechanisms to inhibit growth of human and mouse tumoral cells, BMC Complement. Altern. Med., 8, 10.1186/1472-6882-8-60 Urueña, 2013, Gallotannin-rich Caesalpinia spinosa fraction decreases the primary tumor and factors associated with poor prognosis in a murine breast cancer model, BMC Complement. Altern. Med., 13, 10.1186/1472-6882-13-74 Willers, 2011, Post-transcriptional regulation of the mitochondrial H+ATP synthase: a key regulator of the metabolic phenotype in cancer, Biochim. Biophys. Acta, 1807, 543, 10.1016/j.bbabio.2010.10.016 Zhang, 2014, Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments, Nat. Commun., 5 Zheng, 2000, Inhibition of mitochondrial proton F0F1-ATPase/ATP synthase by polyphenolic phytochemicals, Br. J. Pharmacol., 130, 1115, 10.1038/sj.bjp.0703397 Zhou, 2010, Warburg effect in chemosensitivity: targeting lactate dehydrogenase-A re-sensitizes taxol-resistant cancer cells to taxol, Mol. Cancer, 9, 10.1186/1476-4598-9-33