Respirology

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Obesity, obstructive sleep apnoea and metabolic syndrome
Respirology - Tập 17 Số 2 - Trang 223-236 - 2012
Jamie C.M. Lam, Jcw Mak, Msm Ip
ABSTRACTOSA is increasingly recognized as a major health problem in developed countries. Obesity is the most common risk factor in OSA and hence, the prevalence of OSA is undoubtedly rising given the epidemic of obesity. Recent data also suggest that OSA is highly associated with the metabolic syndrome, and it is postulated that OSA contributes to cardiometabolic dysfunction, and subsequently vasc... hiện toàn bộ
The immunology of tuberculosis: From bench to bedside
Respirology - Tập 15 Số 3 - Trang 433-450 - 2010
Keertan Dheda, Stephan Schwander, Bingdong Zhu, Richard N. van Zyl-Smit, Ying Zhang
ABSTRACTTuberculosis (TB) is an international public health priority and kills almost two million people annually. TB is out of control in Africa due to increasing poverty and HIV coinfection, and drug‐resistant TB threatens to destabilize TB control efforts in several regions of the world. Existing diagnostic tools and therapeutic interventions for TB are suboptimal. Thus, new vaccines, immunothe... hiện toàn bộ
Correlates of erectile dysfunction in moderate‐to‐severe chronic obstructive pulmonary disease patients
Respirology - Tập 12 Số 2 - Trang 248-253 - 2007
Fisun Karadağ, H. Nursun Özcan, Aslıhan Karul, Emel Ceylan, Orhan Çildağ
Objective and background:  Erectile dysfunction (ED) has important negative effects on male quality of life and self‐esteem. The aim of this study was to acquire an insight into the sexual status of COPD patients.Methods:  Ninety‐five male patients aged 48–75 years, with moderate‐to‐severe stable COPD, and 30 age‐matched subjects with normal pulmonary function were included. After clinical evaluat... hiện toàn bộ
Stopping tuberculosis in the 21st century: Goals and strategies
Respirology - Tập 15 Số 1 - Trang 32-43 - 2010
Irwin Law, Mario Raviǵlione
ABSTRACTThe Stop TB Strategy and the Global Plan to Stop TB were launched in 2006 to achieve the tuberculosis (TB)‐related Millennium Development Goals and the Stop TB Partnership targets, and to address new challenges such as that of HIV‐associated TB and multi‐drug‐resistant TB. This paper reviews the historical and recent progress in TB control to show what has changed since the introduction of... hiện toàn bộ
Electronic cigarettes: ‘Vaping’ has unproven benefits and potential harm
Respirology - Tập 19 Số 7 - Trang 945-947 - 2014
David Lam, Arth Nana, Peter R. Eastwood
Pollen proteolytic enzymes degrade tight junctions
Respirology - Tập 12 Số 6 - Trang 834-842 - 2007
Sarah K. Runswick, Thomas K. Mitchell, Paul Davies, C. Robinson, David R. Garrod
Background and objective:  Asthma and allergic rhinitis are significant, increasing causes of morbidity worldwide. Pollen, a major cause of seasonal rhinitis/conjunctivitis, carries proteolytic enzymes on its surface. We showed previously that peptidase allergens from house dust mites compromise epithelial barrier function by degrading the extracellular domains of the tight junction proteins, occl... hiện toàn bộ
The relative survival of COPD patients on long‐term oxygen therapy in Australia: A comparative study
Respirology - Tập 9 Số 2 - Trang 237-242 - 2004
Josephine M Cranston, Anh Minh Nguyen, Alan Crockett
Objective:  The survival of patients with COPD on long‐term oxygen therapy (LTOT) has been studied using both univariate and multivariate procedures. There has been only one previous report of relative survival. Relative survival takes into account the risk of death due to increasing age. The objective of this study was to determine the relative survival of a group of South Australian patients pre... hiện toàn bộ
Exhaled nitric oxide continues to reflect airway hyperresponsiveness and disease activity in inhaled corticosteroid‐treated adult asthmatic patients
Respirology - Tập 8 Số 4 - Trang 479-486 - 2003
David W. Reid, DP Johns, Bryce Feltis, Chris Ward, E. Haydn Walters
Objective:  Exhaled nitric oxide (eNO) has been used as a surrogate of airway inflammation in mild asthma. However, whether eNO levels reflect disease activity in symptomatic asthmatics receiving moderate doses of inhaled corticosteroid (ICS) is more uncertain.Methodology:  To examine the relationship between eNO levels, sputum and blood eosinophils (SpE and PbE), PD20 methacholine as a marker of ... hiện toàn bộ
Update on tuberculosis biomarkers: From correlates of risk, to correlates of active disease and of cure from disease
Respirology - Tập 23 Số 5 - Trang 455-466 - 2018
Delia Goletti, Meng‐Rui Lee, Jann‐Yuan Wang, Nicholas D. Walter, Tom H. M. Ottenhoff
ABSTRACTTuberculosis (TB) remains a devastating disease, yet despite its enormous toll on global health, tools to control TB are insufficient and often outdated. TB Biomarkers (TB‐BM) would constitute extremely useful tools to measure infection status and predict outcome of infection, vaccination or therapy. There are several types of TB‐BM: Correlate of Infection; Correlate of TB Disease; Correla... hiện toàn bộ
Interferon‐γ responses after isoniazid chemotherapy for latent tuberculosis
Respirology - Tập 13 Số 3 - Trang 468-472 - 2008
Kazue Higuchi, Nobuyuki Harada, Toru Mori
Background and objective:  Chemotherapy for Mycobacterium tuberculosis infection may decrease interferon (IFN)‐γ responses to early secretory antigenic target 6 and culture filtrate protein (CFP)‐10; a reaction that could be useful to monitor the success of treatment. We investigated IFN‐γ responses in subjects with latent TB infection before and after isoniazid (INH) chemotherapy.Methods:  A tota... hiện toàn bộ
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