Interferon‐γ responses after isoniazid chemotherapy for latent tuberculosis

Respirology - Tập 13 Số 3 - Trang 468-472 - 2008
Kazue Higuchi1, Nobuyuki Harada2, Toru Mori3
1Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan
2Research Institute of Tuberculosis, Japan Anti‐Tuberculosis Association, and
3Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan

Tóm tắt

Background and objective:  Chemotherapy for Mycobacterium tuberculosis infection may decrease interferon (IFN)‐γ responses to early secretory antigenic target 6 and culture filtrate protein (CFP)‐10; a reaction that could be useful to monitor the success of treatment. We investigated IFN‐γ responses in subjects with latent TB infection before and after isoniazid (INH) chemotherapy.Methods:  A total of 48 patients who had contact with a TB patient in a psychiatric hospital were suspected to have latent TB infection on the basis of a positive QuantiFERON‐TB Gold (QFT‐G) test and were offered INH treatment for 6 months. After INH chemotherapy, IFN‐γ responses were again quantified and compared with initial measurements.Results:  Thirty‐four patients completed 6 months of therapy and 28 were retested. Seven (25%) had a negative test and the other patients showed an overall decline. Geometric mean for early secretory antigenic target 6 decreased from 1.398 to 0.362 (P < 0.001), and that for CFP‐10 from 0.312 to 0.120 (P < 0.001). A subsequent QFT‐G test carried out 18 months after chemotherapy showed no further decline of IFN‐γ responses.Conclusions:  If the success of chemotherapy is defined as negative conversion in the QFT‐G test, these results suggest that although the waning of QFT‐G responses as a result of chemotherapy is an important characteristic of IFN‐γ responses, the extent of waning would not be sufficient to allow effective monitoring of the success of chemotherapy because a majority of contacts still showed positive responses in the QFT‐G test even after chemotherapy.

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Respirology

Tập 13 Số 3

468-472

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