The airway epithelium: Structural and functional properties in health and disease Tập 8 Số 4 - Trang 432-446 - 2003
Darryl A. Knight, Stephen T. Holgate
Abstract: The major function of the respiratory epithelium was once thought to be that of a physical barrier. However, it constitutes the interface between the internal milieu and the external environment as well as being a primary target for inhaled respiratory drugs. It also responds to changes in the external environment by secreting a large number of molecules a...... hiện toàn bộ Diagnostic yield of transbronchial cryobiopsy in interstitial lung disease: A randomized trial Tập 19 Số 6 - Trang 900-906 - 2014
Virginia Pajares, Carmen Puzo, Diego Castillo, Enrique Lerma, M. Angeles Montero, David Ramos‐Barbón, Óscar Amor-Carro, Angels Gil de Bernabé, Tomás Franquet, Vicente Plaza, Jürgen Hetzel, J. Sanchís, Alfons Torrego
AbstractBackground and objectiveTransbronchial lung biopsy (TBLB) is required for evaluation in selected patients with interstitial lung disease (ILD). The diagnostic yield of histopathologic assessment is va...... hiện toàn bộ Women and tobacco Tập 8 Số 2 - Trang 123-130 - 2003
Judith Mackay, Amanda Amos
Abstract: Smoking prevalence is lower among women than men in most countries, yet there are about 200 million women in the world who smoke, and in addition, there are millions more who chew tobacco. Approximately 22% of women in developed countries and 9% of women in developing countries smoke, but because most women live in developing countries, there are numerical...... hiện toàn bộ Silica‐associated lung disease: An old‐world exposure in modern industries Tập 24 Số 12 - Trang 1165-1175 - 2019
Hayley Barnes, Nicole Goh, Tracy L. Leong, Ryan Hoy
ABSTRACTDespite silica dust exposure being one of the earliest recognized causes of lung disease, Australia, USA, Israel, Turkey and other countries around the world have recently experienced significant outbreaks of silicosis. These outbreaks have occurred in modern industries such as denim jean production, domestic benchtop fabrication and jewellery polishing, wh...... hiện toàn bộ Obesity and craniofacial structure as risk factors for obstructive sleep apnoea: Impact of ethnicity Tập 17 Số 2 - Trang 213-222 - 2012
Kate Sutherland, Richard W. W. Lee, Peter A. Cistulli
ABSTRACTOSA is the result of structural and functional abnormalities that promote the repetitive collapse of the upper airway during sleep. This common disorder is estimated to occur in approximately 4% of men and 2% of women, with prevalence studies from North America, Australia, Europe and Asia indicating that occurrence is relatively similar across the globe. An...... hiện toàn bộ The immunology of tuberculosis: From bench to bedside Tập 15 Số 3 - Trang 433-450 - 2010
Keertan Dheda, Stephan Schwander, Bingdong Zhu, Richard N. van Zyl-Smit, Ying Zhang
ABSTRACTTuberculosis (TB) is an international public health priority and kills almost two million people annually. TB is out of control in Africa due to increasing poverty and HIV coinfection, and drug‐resistant TB threatens to destabilize TB control efforts in several regions of the world. Existing diagnostic tools and therapeutic interventions for TB are suboptim...... hiện toàn bộ Pollen proteolytic enzymes degrade tight junctions Tập 12 Số 6 - Trang 834-842 - 2007
Sarah K. Runswick, Thomas K. Mitchell, Paul Davies, C. Robinson, David R. Garrod
Background and objective: Asthma and allergic rhinitis are significant, increasing causes of morbidity worldwide. Pollen, a major cause of seasonal rhinitis/conjunctivitis, carries proteolytic enzymes on its surface. We showed previously that peptidase allergens from house dust mites compromise epithelial barrier function by degrading the extracellular domains of th...... hiện toàn bộ Obesity, obstructive sleep apnoea and metabolic syndrome Tập 17 Số 2 - Trang 223-236 - 2012
Jamie C.M. Lam, Jcw Mak, Msm Ip
ABSTRACTOSA is increasingly recognized as a major health problem in developed countries. Obesity is the most common risk factor in OSA and hence, the prevalence of OSA is undoubtedly rising given the epidemic of obesity. Recent data also suggest that OSA is highly associated with the metabolic syndrome, and it is postulated that OSA contributes to cardiometabolic d...... hiện toàn bộ The role of acute and chronic respiratory colonization and infections in the pathogenesis of COPD Tập 22 Số 4 - Trang 634-650 - 2017
Janice M. Leung, Pei Yee Tiew, Micheál Mac Aogáin, Kurtis F. Budden, V. Wee Yong, Sajan Thomas, Kévin Pethe, Philip M. Hansbro, Sanjay H. Chotirmall
ABSTRACT
COPD is a major global concern, increasingly so in the context of ageing populations. The role of infections in disease pathogenesis and progression is known to be important, yet the mechanisms involved remain to be fully elucidated. While COPD... hiện toàn bộ