Correlates of erectile dysfunction in moderate‐to‐severe chronic obstructive pulmonary disease patients

Respirology - Tập 12 Số 2 - Trang 248-253 - 2007
Fisun Karadağ1, H. Nursun Özcan2, Aslıhan Karul3, Emel Ceylan2, Orhan Çildağ2
1Department of Chest Diseases, School of Medicine, Adnan Menderes University, Aydin, Turkey
2Departments of Chest Diseases and
3Biochemistry, School of Medicine, Adnan Menderes University, Aydin-Turkey;

Tóm tắt

Objective and background:  Erectile dysfunction (ED) has important negative effects on male quality of life and self‐esteem. The aim of this study was to acquire an insight into the sexual status of COPD patients.Methods:  Ninety‐five male patients aged 48–75 years, with moderate‐to‐severe stable COPD, and 30 age‐matched subjects with normal pulmonary function were included. After clinical evaluation and measurement of serum sex hormones and TNF‐α concentration, subjects were asked to answer the International Index of Erectile Function (IIEF) questionnaire as a method to diagnose and classify ED.Results:  Varying degrees of ED were detected in 87% of COPD patients and 83% of controls. Although the total percentages of subjects with various severities of ED seemed similar, moderate and severe ED was 57% in COPD group and 20% in control subjects, suggesting a more severe course of ED in COPD patients. ED score of COPD patients was not correlated with age, smoking burden, duration of COPD, FEV1%, PaO2, PaCO2, serum dehydroepiandrosterone‐sulphate, testosterone or estradiol levels. When patients were subgrouped according to severity of ED, serum TNF‐α concentration, used as a marker of systemic inflammatory status in COPD, was significantly higher in patients with moderate‐to‐severe ED compared with mild‐moderate ED.Conclusion:  The present study showed that ED is frequent and more severe in COPD patients than age‐matched controls. Chronic systemic inflammation is likely to play a role in ED in COPD; the role of TNF‐α should be evaluated further. Patients with COPD need comprehensive management including a detailed sexual evaluation.

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Respirology

Tập 12 Số 2

248-253

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