Quantitative Biology
ESCI-ISI SCOPUS (2013-2023)
2095-4697
2095-4689
Cơ quản chủ quản: Higher Education Press
Lĩnh vực:
Modeling and SimulationComputer Science ApplicationsBiochemistry, Genetics and Molecular Biology (miscellaneous)Applied Mathematics
Các bài báo tiêu biểu
Analysis of alternative cleavage and polyadenylation in mature and differentiating neurons using RNA‐seq dataBackground Most eukaryotic protein‐coding genes exhibit alternative cleavage and polyadenylation (APA), resulting in mRNA isoforms with different 3′ untranslated regions (3′ UTRs). Studies have shown that brain cells tend to express long 3′ UTR isoforms using distal cleavage and polyadenylation sites (PASs). Methods...
- 2018
Computational methodology for ChIP‐seq analysisChromatin immunoprecipitation coupled with massive parallel sequencing (ChIP‐seq) is a powerful technology to identify the genome‐wide locations of DNA binding proteins such as transcription factors or modified histones. As more and more experimental laboratories are adopting ChIP‐seq to unravel the transcriptional and epigenetic regulatory mechanisms, computational analyses of ChIP‐seq al... ...
Tập 1 Số 1 - Trang 54-70 - 2013
Synthetic biology: a new approach to study biological pattern formation
Tập 1 - Trang 246-252 - 2014
The principles and molecular mechanisms underlying biological pattern formation are difficult to elucidate in most cases due to the overwhelming physiologic complexity associated with the natural context. The understanding of a particular mechanism, not to speak of underlying universal principles, is difficult due to the diversity and uncertainty of the biological systems. Although current genetic......
Cistrome Data Browser and Toolkit: analyzing human and mouse genomic data using compendia of ChIP‐seq and chromatin accessibility dataThe Cistrome Data Browser (DB) at the website (cistrome.org/db ) provides about 56,000 published human and mouse ChIP‐seq, DNase‐seq, and ATAC‐seq chromatin profiles, which we have processed using uniform analysis and quality control pipelines. The Cistrome DB Toolkit at the website ( hiện toàn bộ
Tập 8 Số 3 - Trang 267-276 - 2020
Identifying miRNA‐disease association based on integrating miRNA topological similarity and functional similarityBackground MicroRNAs (miRNAs) are a significant type of non‐coding RNAs, which usually were encoded by endogenous genes with about ~22 nt nucleotides. Accumulating biological experiments have shown that miRNAs have close associations with various human diseases. Although traditional experimental methods achieve great successes in miRNA‐disease interaction ...
Tập 7 Số 3 - Trang 202-209 - 2019
Perspective on the q‐bio Summer School and Conference: 2007 – 2014 and beyond
Tập 2 Số 1 - Trang 54-58 - 2014
A resistant method for landmark‐based analysis of individual asymmetry in two dimensionsBackground Symmetry of biological structures can be thought as the repetition of their parts in different positions and orientations. Asymmetry analyses, therefore, focuses on identifying and measuring the location and extent of symmetry departures in such structures. In the context of geometric morphometrics, a key step when studying morphological variati...
- 2016
Transcriptome assembly strategies for precision medicineBackground Precision medicine approach holds great promise to tailored diagnosis, treatment and prevention. Individuals can be vastly different in their genomic information and genetic mechanisms hence having unique transcriptomic signatures. The development of precision medicine has
demanded moving beyond DNA sequencing (DNA‐Seq) to much more pointed RNA‐...
- 2017
TACO: Taxonomic prediction of unknown OTUs through OTU co‐abundance networksBackground A main goal of metagenomics is taxonomic characterization of microbial communities. Although sequence comparison has been the main method for the taxonomic classification, there is not a clear agreement on similarity calculation and similarity thresholds, especially at higher taxonomic levels such as phylum and class. Thus taxonomic classificati...
- 2016