Transcriptome assembly strategies for precision medicine

Quantitative Biology - 2017
Lu Wang1, Lipi Acharya2, Changxin Bai1, Dongxiao Zhu1
1Wayne State University
2DOW AgroSciences

Tóm tắt

BackgroundPrecision medicine approach holds great promise to tailored diagnosis, treatment and prevention. Individuals can be vastly different in their genomic information and genetic mechanisms hence having unique transcriptomic signatures. The development of precision medicine has demanded moving beyond DNA sequencing (DNA‐Seq) to much more pointed RNA‐sequencing (RNA‐Seq) [ Cell, 2017, 168: 584–599].ResultsHere we conduct a brief survey on the recent methodology development of transcriptome assembly approach using RNA‐Seq.ConclusionsSince transcriptomes in human disease are highly complex, dynamic and diverse, transcriptome assembly is playing an increasingly important role in precision medicine research to dissect the molecular mechanisms of the human diseases.

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Quantitative Biology

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