Proteomics

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ATR inhibition rewires cellular signaling networks induced by replication stress
Proteomics - Tập 16 Số 3 - Trang 402-416 - 2016
Sebastian Wagner, Hannah Oehler, Andrea Voigt, Denis Dalic, Anja Freiwald, Hubert Serve, Petra Beli
The slowing down or stalling of replication forks is commonly known as replication stress and arises from multiple causes such as DNA lesions, nucleotide depletion, RNA‐DNA hybrids, and oncogene activation. The ataxia telangiectasia and Rad3‐related kinase (ATR) plays an essential role in the cellular response to replication stress and inhibition of ATR has emerged as therapeutic strategy ...... hiện toàn bộ
A combination of proteomics, principal component analysis and transcriptomics is a powerful tool for the identification of biomarkers for macrophage maturation in the U937 cell line
Proteomics - Tập 4 Số 4 - Trang 1014-1028 - 2004
Kitty Verhoeckx, Sabina Bijlsma, Els M. de Groene, Renger F. Witkamp, J. van der Greef, Richard J. Rodenburg
AbstractThe monocyte‐like human histiocytic lymphoma cell line U937 can be induced by phorbol 12‐myristate 13‐acetate (PMA) to undergo differentiation into a macrophage‐like phenotype. We have used two‐dimensional gel electrophoresis (2‐DE), oligonucleotide microarrays and principal component analysis (PCA) to characterize the U937 cell line as a model system for t...... hiện toàn bộ
Bothrops jararaca venom proteome rearrangement upon neonate to adult transition
Proteomics - Tập 11 Số 21 - Trang 4218-4228 - 2011
André Zelanis, Alexandre K. Tashima, Antônio F. M. Pinto, Adriana Franco Paes Leme, Daniel Rodrigues Stuginski, Maria F. Furtado, Nicholas E. Sherman, Paulo Lee Ho, Jay W. Fox, Solange M.T. Serrano
AbstractThe pharmacological activities displayed by Bothrops jararaca venom undergo a significant ontogenetic shift. Similarly, the diet of this species changes from ectothermic prey in early life to endothermic prey in adulthood. In this study we used large and representative newborn and adult venom samples consisting of pools from 694 a...... hiện toàn bộ
A novel targeted proteomics method for identification and relative quantitation of difference in nitration degree of OGDH between healthy and diabetic mouse
Proteomics - Tập 14 Số 21-22 - Trang 2417-2426 - 2014
Qing Yu, Bin Liu, Dan‐dan Ruan, Chao Niu, Jiayi Shen, Maowei Ni, Weitao Cong, Xianghong Lu, Litai Jin
Proteomic analysis of the acid‐soluble organic matrix of the chicken calcified eggshell layer
Proteomics - Tập 6 Số 13 - Trang 3801-3810 - 2006
Karlheinz Mann, Boris Maček, Jesper V. Olsen
AbstractThe major difference between inorganic minerals and biominerals is the presence of an organic matrix consisting of proteins, glycoproteins, proteoglycans, and polysaccharides, which is synthesized by specialized cells under genetic control before or during mineralization. The organic matrix is thought to play a major role in the assembly of the biomineral a...... hiện toàn bộ
Proteome analysis of the plant pathogen Xylella fastidiosa reveals major cellular and extracellular proteins and a peculiar codon bias distribution
Proteomics - Tập 3 Số 2 - Trang 224-237 - 2003
Marcus B. Smolka, Daniel Martins‐de‐Souza, Flávia Vischi Winck, Carlos Eduardo Santoro, Rafael Ramos Castellari, Fernanda Ferrari, Itaraju Junior Baracuhy Brum, Eduardo Galembeck, Helvécio Della Coletta-Filho, Marcos Antônio Machado, Sérgio Marangoni, José C. Novello
AbstractThe bacteria Xylella fastidiosa is the causative agent of a number of economically important crop diseases, including citrus variegated chlorosis. Although its complete genome is already sequenced, X. fastidiosa is very poorly characterized by biochemical approaches at the protein level. In an initial ef...... hiện toàn bộ
Detection in human saliva of different statherin and P-B fragments and derivatives
Proteomics - Tập 6 Số 23 - Trang 6370-6379 - 2006
Rosanna Inzitari, Tiziana Cabras, Diana Valeria Rossetti, Chiara Fanali, Alberto Vitali, Mariagiuseppina Pellegrini, Gaetano Paludetti, Armando Manni, Bruno Giardina, Irene Messana, Massimo Castagnola
Different isoforms and post‐translational modifications of human salivary acidic proline‐rich proteins
Proteomics - Tập 5 Số 3 - Trang 805-815 - 2005
Rosanna Inzitari, Tiziana Cabras, Giuseppina Onnis, Chiara Olmi, Andrea Mastinu, Maria Teresa Sanna, Maria Guiseppina Pellegrini, Massimo Castagnola, Irene Messana
AbstractThe human salivary acidic proline‐rich proteins (aPRPs) complex was investigated by different chromatographic and mass spectrometric approaches and the main aPRPs, namely PRP‐1, PRP‐2 and PIF‐s (15 515 amu), Db‐s (17 632 amu) and Pa (15 462 amu) proteins, were detected. All these isoforms are phosphorylated at Ser‐8 and Ser‐22 and have a pyroglutamic moiety...... hiện toàn bộ
Computational analysis of human protein interaction networks
Proteomics - Tập 7 Số 15 - Trang 2541-2552 - 2007
Fidel Ramírez, Andreas Schlicker, Yassen Assenov, Thomas Lengauer, Mario Albrecht
AbstractLarge amounts of human protein interaction data have been produced by experiments and prediction methods. However, the experimental coverage of the human interactome is still low in contrast to predicted data. To gain insight into the value of publicly available human protein network data, we compared predicted datasets, high‐throughput results from yeast t...... hiện toàn bộ
Towards a human proteome atlas: High-throughput generation of mono-specific antibodies for tissue profiling
Proteomics - Tập 5 Số 17 - Trang 4327-4337
Peter Nilsson, Linda Paavilainen, Karin Larsson, Jenny Ödling, Mårten Sundberg, Ann‐Catrin Andersson, Caroline Kampf, Anja Persson, Cristina Al‐Khalili Szigyarto, Jenny Ottosson, Erik Björling, Sophia Hober, Henrik Wernérus, Kenneth Wester, Fredrik Pontén, Mathias Uhlén
Tổng số: 118   
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