Proteomics
SCIE-ISI SCOPUS (2001-2025)
1615-9861
1615-9853
Đức
Cơ quản chủ quản: WILEY , Wiley-VCH Verlag
Lĩnh vực:
BiochemistryMolecular Biology
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Prediction of post‐translational glycosylation and phosphorylation of proteins from the amino acid sequence
Tập 4 Số 6 - Trang 1633-1649 - 2004
AbstractPost‐translational modifications (PTMs) occur on almost all proteins
analyzed to date. The function of a modified protein is often strongly affected
by these modifications and therefore increased knowledge about the potential
PTMs of a target protein may increase our understanding of the molecular
processes in which it takes part. High‐throughput methods for the identification
of PTMs are ...
Current two‐dimensional electrophoresis technology for proteomics
Tập 4 Số 12 - Trang 3665-3685 - 2004
AbstractTwo‐dimensional gel electrophoresis (2‐DE) with immobilized pH gradients
(IPGs) combined with protein identification by mass spectrometry (MS) is
currently the workhorse for proteomics. In spite of promising alternative or
complementary technologies (e.g.multidimensional protein identification
technology, stable isotope labelling, protein or antibody arrays) that have
emerged recently, 2‐D...
The International Protein Index: An integrated database for proteomics experiments
Tập 4 Số 7 - Trang 1985-1988 - 2004
AbstractDespite the complete determination of the genome sequence of several
higher eukaryotes, their proteomes remain relatively poorly defined. Information
about proteins identified by different experimental and computational methods is
stored in different databases, meaning that no single resource offers full
coverage of known and predicted proteins. IPI (the International Protein Index)
has be...
GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis
Tập 19 Số 18 - 2019
AbstractOxygen is necessary for aerobic metabolism but can cause the harmful
oxidation of lipids and other macromolecules. Oxidation of cholesterol and
phospholipids containing polyunsaturated fatty acyl chains can lead to lipid
peroxidation, membrane damage, and cell death. Lipid hydroperoxides are key
intermediates in the process of lipid peroxidation. The lipid hydroperoxidase
glutathione perox...
PRIDE: The proteomics identifications database
Tập 5 Số 13 - Trang 3537-3545 - 2005
AbstractThe advent of high‐throughput proteomics has enabled the identification
of ever increasing numbers of proteins. Correspondingly, the number of
publications centered on these protein identifications has increased
dramatically. With the first results of the HUPO Plasma Proteome Project being
analyzed and many other large‐scale proteomics projects about to disseminate
their data, this trend i...
Metabolomics: Current technologies and future trends
Tập 6 Số 17 - Trang 4716-4723 - 2006
AbstractThe ability to sequence whole genomes has taught us that our knowledge
with respect to gene function is rather limited with typically 30–40% of open
reading frames having no known function. Thus, within the life sciences there is
a need for determination of the biological function of these so‐called orphan
genes, some of which may be molecular targets for therapeutic intervention. The
sear...
Database searching and accounting of multiplexed precursor and product ion spectra from the data independent analysis of simple and complex peptide mixtures
Tập 9 Số 6 - Trang 1696-1719 - 2009
AbstractA novel database search algorithm is presented for the qualitative
identification of proteins over a wide dynamic range, both in simple and complex
biological samples. The algorithm has been designed for the analysis of data
originating from data independent acquisitions, whereby multiple precursor ions
are fragmented simultaneously. Measurements used by the algorithm include
retention tim...
Global quantitative phosphoprotein analysis using Multiplexed Proteomics technology
Tập 3 Số 7 - Trang 1128-1144 - 2003
AbstractSystematic parallel analysis of the phosphorylation status of networks
of interacting proteins involved in the regulatory circuitry of cells and
tissues is certain to drive research in the post‐genomics era for many years to
come. Reversible protein phosphorylation plays a critical regulatory role in a
multitude of cellular processes, including alterations in signal transduction
pathways r...
Proteome analysis of human colon cancer by two‐dimensional difference gel electrophoresis and mass spectrometry
Tập 4 Số 3 - Trang 793-811 - 2004
AbstractTwo‐dimensional difference gel electrophoresis (2‐D DIGE) coupled with
mass spectrometry (MS) was used to investigate tumor‐specific changes in the
proteome of human colorectal cancers and adjacent normal mucosa. For each of six
patients with different stages of colon cancer, Cy5‐labeled proteins isolated
from tumor tissue were combined with Cy3‐labeled proteins isolated from
neighboring n...
Unimod: Protein modifications for mass spectrometry
Tập 4 Số 6 - Trang 1534-1536 - 2004
AbstractUnimod is a database of protein modifications for use in mass
spectrometry applications, especially protein identification and de novo
sequencing. It contains accurate and verifiable values, derived from elemental
compositions, for the mass differences introduced by both natural and artificial
modifications.