Proteomics
SCIE-ISI SCOPUS (2001-2023)
1615-9861
1615-9853
Đức
Cơ quản chủ quản: WILEY , Wiley-VCH Verlag
Lĩnh vực:
BiochemistryMolecular Biology
Các bài báo tiêu biểu
Prediction of post‐translational glycosylation and phosphorylation of proteins from the amino acid sequenceAbstract Post‐translational modifications (PTMs) occur on almost all proteins analyzed to date. The function of a modified protein is often strongly affected by these modifications and therefore increased knowledge about the potential PTMs of a target protein may increase our understanding of the molecular processes in which it takes part. High‐throughput methods fo... ... hiện toàn bộ
Tập 4 Số 6 - Trang 1633-1649 - 2004
Current two‐dimensional electrophoresis technology for proteomicsAbstract Two‐dimensional gel electrophoresis (2‐DE) with immobilized pH gradients (IPGs) combined with protein identification by mass spectrometry (MS) is currently the workhorse for proteomics. In spite of promising alternative or complementary technologies (e.g. multidimensional protein identification technology, stable isotope labelling,... ... hiện toàn bộ
Tập 4 Số 12 - Trang 3665-3685 - 2004
The International Protein Index: An integrated database for proteomics experimentsAbstract Despite the complete determination of the genome sequence of several higher eukaryotes, their proteomes remain relatively poorly defined. Information about proteins identified by different experimental and computational methods is stored in different databases, meaning that no single resource offers full coverage of known and predicted proteins. IPI (the In... ... hiện toàn bộ
Tập 4 Số 7 - Trang 1985-1988 - 2004
GPX4 at the Crossroads of Lipid Homeostasis and FerroptosisAbstract Oxygen is necessary for aerobic metabolism but can cause the harmful oxidation of lipids and other macromolecules. Oxidation of cholesterol and phospholipids containing polyunsaturated fatty acyl chains can lead to lipid peroxidation, membrane damage, and cell death. Lipid hydroperoxides are key intermediates in the process of lipid peroxidation. The lipid ... ... hiện toàn bộ
Tập 19 Số 18 - 2019
PRIDE: The proteomics identifications databaseAbstract The advent of high‐throughput proteomics has enabled the identification of ever increasing numbers of proteins. Correspondingly, the number of publications centered on these protein identifications has increased dramatically. With the first results of the HUPO Plasma Proteome Project being analyzed and many other large‐scale proteomics projects about to dis... ... hiện toàn bộ
Tập 5 Số 13 - Trang 3537-3545 - 2005
Metabolomics: Current technologies and future trendsAbstract The ability to sequence whole genomes has taught us that our knowledge with respect to gene function is rather limited with typically 30–40% of open reading frames having no known function. Thus, within the life sciences there is a need for determination of the biological function of these so‐called orphan genes, some of which may be molecular targets for t... ... hiện toàn bộ
Tập 6 Số 17 - Trang 4716-4723 - 2006
Database searching and accounting of multiplexed precursor and product ion spectra from the data independent analysis of simple and complex peptide mixturesAbstract A novel database search algorithm is presented for the qualitative identification of proteins over a wide dynamic range, both in simple and complex biological samples. The algorithm has been designed for the analysis of data originating from data independent acquisitions, whereby multiple precursor ions are fragmented simultaneously. Measurements used by th... ... hiện toàn bộ
Tập 9 Số 6 - Trang 1696-1719 - 2009
Global quantitative phosphoprotein analysis using Multiplexed Proteomics technologyAbstract Systematic parallel analysis of the phosphorylation status of networks of interacting proteins involved in the regulatory circuitry of cells and tissues is certain to drive research in the post‐genomics era for many years to come. Reversible protein phosphorylation plays a critical regulatory role in a multitude of cellular processes, including alterations ... ... hiện toàn bộ
Tập 3 Số 7 - Trang 1128-1144 - 2003
Proteome analysis of human colon cancer by two‐dimensional difference gel electrophoresis and mass spectrometryAbstract Two‐dimensional difference gel electrophoresis (2‐D DIGE) coupled with mass spectrometry (MS) was used to investigate tumor‐specific changes in the proteome of human colorectal cancers and adjacent normal mucosa. For each of six patients with different stages of colon cancer, Cy5‐labeled proteins isolated from tumor tissue were combined with Cy3‐labeled pro... ... hiện toàn bộ
Tập 4 Số 3 - Trang 793-811 - 2004
Unimod: Protein modifications for mass spectrometryAbstract Unimod is a database of protein modifications for use in mass spectrometry applications, especially protein identification and de novo sequencing. It contains accurate and verifiable values, derived from elemental compositions, for the mass differences introduced by both natural and artificial modifications.
Tập 4 Số 6 - Trang 1534-1536 - 2004