Proceedings of the National Academy of Sciences of the United States of America

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Superoxide dismutase is dispensable for normal animal lifespan
Proceedings of the National Academy of Sciences of the United States of America - Tập 109 Số 15 - Trang 5785-5790 - 2012
Jeremy M. Van Raamsdonk, Siegfried Hekimi
Reactive oxygen species (ROS) are toxic oxygen-containing molecules that can damage multiple components of the cell and have been proposed to be the primary cause of aging. The antioxidant enzyme superoxide dismutase (SOD) is the only eukaryotic enzyme capable of detoxifying superoxide, one type of ROS. The fact that SOD is present in all aerobic organisms raises the question ...... hiện toàn bộ
Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America - Tập 93 Số 18 - Trang 9782-9787 - 1996
Russell M. Lebovitz, Henggui Zhang, Hannes Vogel, Joiner Cartwright, Louise A. Dionne, Ning Lü, Shixia Huang, Martin M. Matzuk
Manganese superoxide dismutase (SOD2) converts superoxide to oxygen plus hydrogen peroxide and serves as the primary defense against mitochondrial superoxide. Impaired SOD2 activity in humans has been associated with several chronic diseases, including ovarian cancer and type I diabetes, and SOD2 overexpression appears to suppress malignancy in cultured cells. We have produced a line of SO...... hiện toàn bộ
Targeted disruption of gene function in Drosophila by RNA interference (RNA-i): A role for nautilus in embryonic somatic muscle formation
Proceedings of the National Academy of Sciences of the United States of America - Tập 96 Số 4 - Trang 1451-1456 - 1999
Leonie Misquitta, Bruce M. Paterson
The expression of the MyoD gene homolog, nautilus (nau), in the Drosophila embryo defines a subset of mesodermal cells known as the muscle “pioneer” or “founder” cells. These cells are thought to establish the future muscle pattern in each hemisegment. Founders appear to re...... hiện toàn bộ
A unique mechanism regulating gene expression: translational inhibition by a complementary RNA transcript (micRNA).
Proceedings of the National Academy of Sciences of the United States of America - Tập 81 Số 7 - Trang 1966-1970 - 1984
Takeshi Mizuno, Ming-Yi Chou, Masayori Inouye
The expression of the genes for the major outer membrane proteins OmpF and OmpC are osmoregulated. The ompC locus was found to be transcribed bidirectionally under conditions of high osmolarity and a 174-base transcript encoded upstream of ompC was found to inhibit the OmpF production and to substantially reduce the amount of the ompF mRNA. This RNA [mRNA-interfering complementary RNA (mic...... hiện toàn bộ
Diffusive reaction dynamics on invariant free energy profiles
Proceedings of the National Academy of Sciences of the United States of America - Tập 105 Số 37 - Trang 13841-13846 - 2008
Sergei V. Krivov, Martin Karplus
A fundamental problem in the analysis of protein folding and other complex reactions in which the entropy plays an important role is the determination of the activation free energy from experimental measurements or computer simulations. This article shows how to combine minimum-cut-based free energy profiles ( F C...... hiện toàn bộ
Transition paths, diffusive processes, and preequilibria of protein folding
Proceedings of the National Academy of Sciences of the United States of America - Tập 109 Số 51 - Trang 20919-20924 - 2012
Zhuqing Zhang, Hue Sun Chan
Fundamental relationships between the thermodynamics and kinetics of protein folding were investigated using chain models of natural proteins with diverse folding rates by extensive comparisons between the distribution of conformations in thermodynamic equilibrium and the distribution of conformations sampled along folding trajectories. Consistent with theory and single-molecule experiment...... hiện toàn bộ
Spontaneous formation of the unlocked state of the ribosome is a multistep process
Proceedings of the National Academy of Sciences of the United States of America - Tập 107 Số 2 - Trang 709-714 - 2010
James B. Munro, Russ B. Altman, Chang‐Shung Tung, Jamie H. D. Cate, Karissa Y. Sanbonmatsu, Scott C. Blanchard
The mechanism of substrate translocation through the ribosome is central to the rapid and faithful translation of mRNA into proteins. The rate-limiting step in translocation is an unlocking process that includes the formation of an “unlocked” intermediate state, which requires the convergence of large-scale conformational events within the ribosome including tRNA hybrid states formation, c...... hiện toàn bộ
Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis
Proceedings of the National Academy of Sciences of the United States of America - Tập 107 Số 34 - Trang 15163-15168 - 2010
Jr-Shiuan Yang, Thomas Maurin, Nicolas Robine, K Rasmussen, Kate L. Jeffrey, Rohit Chandwani, Eirini P. Papapetrou, Michel Sadelain, Dónal O’Carroll, Eric C. Lai
Canonical animal microRNAs (miRNAs) are generated by sequential cleavage of precursor substrates by the Drosha and Dicer RNase III enzymes. Several variant pathways exploit other RNA metabolic activities to generate functional miRNAs. However, all of these pathways culminate in Dicer cleavage, suggesting that this is a unifying feature of miRNA biogenesis. Here, we show that m...... hiện toàn bộ
Dynamic reorganization of the functionally active ribosome explored by normal mode analysis and cryo-electron microscopy
Proceedings of the National Academy of Sciences of the United States of America - Tập 100 Số 16 - Trang 9319-9323 - 2003
Florence Tama, Mikel Valle, Joachim Frank, Charles L. Brooks
Combining structural data for the ribosome from x-ray crystallography and cryo-electron microscopy with dynamic models based on elastic network normal mode analysis, an atomically detailed picture of functionally important structural rearrangements that occur during translocation is elucidated. The dynamic model provides a near-atomic description of the ratchet-like rearrangement of t...... hiện toàn bộ
Refolding dynamics of stretched biopolymers upon force quench
Proceedings of the National Academy of Sciences of the United States of America - Tập 106 Số 48 - Trang 20288-20293 - 2009
Changbong Hyeon, Greg Morrison, David L. Pincus, D. Thirumalai
Single-molecule force spectroscopy methods can be used to generate folding trajectories of biopolymers from arbitrary regions of the folding landscape. We illustrate the complexity of the folding kinetics and generic aspects of the collapse of RNA and proteins upon force quench by using simulations of an RNA hairpin and theory based on the de Gennes model for homopolymer colla...... hiện toàn bộ
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