Proceedings of the National Academy of Sciences of the United States of America

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Nitric oxide synthase generates nitric oxide locally to regulate compartmentalized protein S-nitrosylation and protein trafficking
Proceedings of the National Academy of Sciences of the United States of America - Tập 103 Số 52 - Trang 19777-19782 - 2006
Yasuko Iwakiri, Ayano Satoh, Suvro Chatterjee, Derek Toomre, Cécile Chalouni, David Fulton, Roberto J. Groszmann, Vijay H. Shah, William C. Sessa
Nitric oxide (NO) is a highly diffusible and short-lived physiological messenger. Despite its diffusible nature, NO modifies thiol groups of specific cysteine residues in target proteins and alters protein function via S-nitrosylation. Although intracellular S-nitrosylation is a specific posttranslational modification, the defined localization of an NO source (nitric oxide syn...... hiện toàn bộ
HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator
Proceedings of the National Academy of Sciences of the United States of America - Tập 95 Số 9 - Trang 5281-5286 - 1998
Lisa K. Felzien, Clive Woffendin, Michael O. Hottiger, Ramu A. Subbramanian, Éric A. Cohen, Gary J. Nabel
The accessory protein, Vpr, is a virion-associated protein that is required for HIV-1 replication in macrophages and regulates viral gene expression in T cells. Vpr causes arrest of cell cycle progression at G 2 /M, presumably through its effect on cyclin B1⋅Cdc2 activity. Here, we show that the ability of Vpr to activate HIV transc...... hiện toàn bộ
DNA packaging and ejection forces in bacteriophage
Proceedings of the National Academy of Sciences of the United States of America - Tập 98 Số 24 - Trang 13671-13674 - 2001
James T. Kindt, Shelly Tzlil, Avinoam Ben‐Shaul, William M. Gelbart
We calculate the forces required to package (or, equivalently, acting to eject) DNA into (from) a bacteriophage capsid, as a function of the loaded (ejected) length, under conditions for which the DNA is either self-repelling or self-attracting. Through computer simulation and analytical theory, we find the loading force to increase more than 10-fold (to tens of piconewtons) during the fin...... hiện toàn bộ
Global sea level linked to global temperature
Proceedings of the National Academy of Sciences of the United States of America - Tập 106 Số 51 - Trang 21527-21532 - 2009
Martin Vermeer, Stefan Rahmstorf
We propose a simple relationship linking global sea-level variations on time scales of decades to centuries to global mean temperature. This relationship is tested on synthetic data from a global climate model for the past millennium and the next century. When applied to observed data of sea level and temperature for 1880–2000, and taking into account known anthropogenic hydrologic contrib...... hiện toàn bộ
Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample
Proceedings of the National Academy of Sciences of the United States of America - - 2011
J. Gregory Caporaso, Christian L. Lauber, William A. Walters, Donna Berg-Lyons, Catherine Lozupone, Peter J. Turnbaugh, Noah Fierer, Rob Knight
The ongoing revolution in high-throughput sequencing continues to democratize the ability of small groups of investigators to map the microbial component of the biosphere. In particular, the coevolution of new sequencing platforms and new software tools allows data acquisition and analysis on an unprecedented scale. Here we report the next stage in this coevolutionary arms race, using the ...... hiện toàn bộ
Emergent linguistic structure in artificial neural networks trained by self-supervision
Proceedings of the National Academy of Sciences of the United States of America - Tập 117 Số 48 - Trang 30046-30054 - 2020
Christopher D. Manning, Kevin Clark, John Hewitt, Urvashi Khandelwal, Omer Levy
This paper explores the knowledge of linguistic structure learned by large artificial neural networks, trained via self-supervision, whereby the model simply tries to predict a masked word in a given context. Human language communication is via sequences of words, but language understanding requires constructing rich hierarchical structures that are never observed explicitly. The mechanism...... hiện toàn bộ
Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival
Proceedings of the National Academy of Sciences of the United States of America - Tập 102 Số 10 - Trang 3738-3743 - 2005
Howard Y. Chang, Dimitry S.A. Nuyten, Julie B. Sneddon, Trevor Hastie, Robert Tibshirani, Thérese Sørlie, Hongyue Dai, Yudong D. He, Laura J. van’t Veer, Harry Bartelink, Matt van de Rijn, Patrick O. Brown, Marc J. van de Vijver
Based on the hypothesis that features of the molecular program of normal wound healing might play an important role in cancer metastasis, we previously identified consistent features in the transcriptional response of normal fibroblasts to serum, and used this “wound-response signature” to reveal links between wound healing and cancer progression in a variety of common epithelial tumors. H...... hiện toàn bộ
Gender differences in age effect on brain atrophy measured by magnetic resonance imaging.
Proceedings of the National Academy of Sciences of the United States of America - Tập 88 Số 7 - Trang 2845-2849 - 1991
Ruben C. Gur, P. David Mozley, Susan M. Resnick, Gary Gottlieb, Mark Kohn, Robert A. Zimmerman, Gábor T. Herman, Susan J. Atlas, Robert L. Grossman, Deborah A. Berretta
A prospective sample of 69 healthy adults, age range 18-80 years, was studied with magnetic resonance imaging scans (T2 weighted, 5 mm thick) of the entire cranium. Volumes were obtained by a segmentation algorithm that uses proton density and T2 pixel values to correct field inhomogeneities ("shading"). Average (+/- SD) brain volume, excluding cerebellum, was 1090.91 ml (+/- 114.30; range...... hiện toàn bộ
Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45
Proceedings of the National Academy of Sciences of the United States of America - Tập 98 Số 11 - Trang 6051-6055 - 2001
Pei Zhou, Alexey A. Lugovskoy, J S McCarty, Peng Li, Gerhard Wagner
Apoptotic DNA fragmentation is mediated by a caspase-activated DNA fragmentation factor (DFF)40. Expression and folding of DFF40 require the presence of DFF45, which also acts as a nuclease inhibitor before DFF40 activation by execution caspases. The N-terminal domains (NTDs) of both proteins are homologous, and their interaction plays a key role in the proper functioning of this two...... hiện toàn bộ
Field- and clinically derived estimates of Wolbachia -mediated blocking of dengue virus transmission potential in Aedes aegypti mosquitoes
Proceedings of the National Academy of Sciences of the United States of America - Tập 115 Số 2 - Trang 361-366 - 2018
Lauren B. Carrington, Bich Chau Nguyen Tran, Le Thanh Hoang Nhat, Tai Thi Hue Luong, Truong Thanh Nguyen, Phong Thanh Nguyen, Nguyễn Văn Vĩnh Châu, Nguyen Thi Cam Huong, Trung Vu, Long Thi Vo, Dui Thi Le, Nhu Tuyet Vu, Giang Nguyen, Hung Quoc Luu, Anh Duc Dang, Timothy P. Hurst, Scott L. O’Neill, Vi Tran, Duong Thi Hue Kien, Nguyet Minh Nguyen, Marcel Wolbers, Bridget Wills, Cameron P. Simmons
Significance In laboratory experiments, Wolbachia ( w Mel strain)-infected Aedes aegypti are refractory to disseminated arboviral infections. Yet previous characterizations of ... hiện toàn bộ
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