Proceedings of the National Academy of Sciences of the United States of America

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Targeted disruption of gene function in Drosophila by RNA interference (RNA-i): A role for nautilus in embryonic somatic muscle formation
Proceedings of the National Academy of Sciences of the United States of America - Tập 96 Số 4 - Trang 1451-1456 - 1999
Leonie Misquitta, Bruce M. Paterson
The expression of the MyoD gene homolog, nautilus (nau), in the Drosophila embryo defines a subset of mesodermal cells known as the muscle “pioneer” or “founder” cells. These cells are thought to establish the future muscle pattern in each hemisegment. Founders appear to re...... hiện toàn bộ
Diffusive reaction dynamics on invariant free energy profiles
Proceedings of the National Academy of Sciences of the United States of America - Tập 105 Số 37 - Trang 13841-13846 - 2008
Sergei V. Krivov, Martin Karplus
A fundamental problem in the analysis of protein folding and other complex reactions in which the entropy plays an important role is the determination of the activation free energy from experimental measurements or computer simulations. This article shows how to combine minimum-cut-based free energy profiles ( F C...... hiện toàn bộ
Spontaneous formation of the unlocked state of the ribosome is a multistep process
Proceedings of the National Academy of Sciences of the United States of America - Tập 107 Số 2 - Trang 709-714 - 2010
James B. Munro, Russ B. Altman, Chang‐Shung Tung, Jamie H. D. Cate, Karissa Y. Sanbonmatsu, Scott C. Blanchard
The mechanism of substrate translocation through the ribosome is central to the rapid and faithful translation of mRNA into proteins. The rate-limiting step in translocation is an unlocking process that includes the formation of an “unlocked” intermediate state, which requires the convergence of large-scale conformational events within the ribosome including tRNA hybrid states formation, c...... hiện toàn bộ
Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis
Proceedings of the National Academy of Sciences of the United States of America - Tập 107 Số 34 - Trang 15163-15168 - 2010
Jr-Shiuan Yang, Thomas Maurin, Nicolas Robine, K Rasmussen, Kate L. Jeffrey, Rohit Chandwani, Eirini P. Papapetrou, Michel Sadelain, Dónal O’Carroll, Eric C. Lai
Canonical animal microRNAs (miRNAs) are generated by sequential cleavage of precursor substrates by the Drosha and Dicer RNase III enzymes. Several variant pathways exploit other RNA metabolic activities to generate functional miRNAs. However, all of these pathways culminate in Dicer cleavage, suggesting that this is a unifying feature of miRNA biogenesis. Here, we show that m...... hiện toàn bộ
Dynamic reorganization of the functionally active ribosome explored by normal mode analysis and cryo-electron microscopy
Proceedings of the National Academy of Sciences of the United States of America - Tập 100 Số 16 - Trang 9319-9323 - 2003
Florence Tama, Mikel Valle, Joachim Frank, Charles L. Brooks
Combining structural data for the ribosome from x-ray crystallography and cryo-electron microscopy with dynamic models based on elastic network normal mode analysis, an atomically detailed picture of functionally important structural rearrangements that occur during translocation is elucidated. The dynamic model provides a near-atomic description of the ratchet-like rearrangement of t...... hiện toàn bộ
Refolding dynamics of stretched biopolymers upon force quench
Proceedings of the National Academy of Sciences of the United States of America - Tập 106 Số 48 - Trang 20288-20293 - 2009
Changbong Hyeon, Greg Morrison, David L. Pincus, D. Thirumalai
Single-molecule force spectroscopy methods can be used to generate folding trajectories of biopolymers from arbitrary regions of the folding landscape. We illustrate the complexity of the folding kinetics and generic aspects of the collapse of RNA and proteins upon force quench by using simulations of an RNA hairpin and theory based on the de Gennes model for homopolymer colla...... hiện toàn bộ
Checkpoints in the progression of autoimmune disease: lessons from diabetes models.
Proceedings of the National Academy of Sciences of the United States of America - Tập 93 Số 6 - Trang 2260-2263 - 1996
Isabelle André‐Schmutz, Antonio González, Bin Wang, Jonathan D. Katz, Christophe Benoist, Diane Mathis
In the last few years, data from experiments employing transgenic models of autoimmune disease have strengthened a particular concept of autoimmunity: disease results not so much from cracks in tolerance induction systems, leading to the generation of anti-self repertoire, as from the breakdown of secondary systems that keep these cells in check. T cells with anti-self specificities are re...... hiện toàn bộ
High sensitivity and interindividual variability in the response of the human circadian system to evening light
Proceedings of the National Academy of Sciences of the United States of America - Tập 116 Số 24 - Trang 12019-12024 - 2019
Andrew J. K. Phillips, Parisa Vidafar, A Burns, Elise M. McGlashan, Clare Anderson, Shantha M. W. Rajaratnam, Steven W. Lockley, Sean W. Cain
Significance Electric lighting has fundamentally altered how the human circadian clock synchronizes to the day/night cycle. Exposure to light after dusk is pervasive in the modern world. We examined group-level sensitivity of the circadian system to evening light and the degree to which sensitivity varies between individuals. We found that, on average, hu...... hiện toàn bộ
Genomewide SNP variation reveals relationships among landraces and modern varieties of rice
Proceedings of the National Academy of Sciences of the United States of America - Tập 106 Số 30 - Trang 12273-12278 - 2009
Millicent D. Alexandrov Sanciangco, Kevin L. Childs, Regina Bohnert, Rebecca M. Davidson, Keyan Zhao, Victor Jun Ulat, Georg Zeller, Richard M. Clark, Douglas Hoen, Thomas E. Bureau, Renee Stokowski, Dennis G. Ballinger, Kelly A. Frazer, David R. Cox, Badri Padhukasahasram, Carlos D. Bustamante, Detlef Weigel, D. J. Mackill, Richard Bruskiewich, Gunnar Rätsch, C. Robin Buell, Hei Leung, Jan E. Leach
Rice, the primary source of dietary calories for half of humanity, is the first crop plant for which a high-quality reference genome sequence from a single variety was produced. We used resequencing microarrays to interrogate 100 Mb of the unique fraction of the reference genome for 20 diverse varieties and landraces that capture the impressive genotypic and phenotypic diversity of domesti...... hiện toàn bộ
Diversity enhances agricultural productivity via rhizosphere phosphorus facilitation on phosphorus-deficient soils
Proceedings of the National Academy of Sciences of the United States of America - Tập 104 Số 27 - Trang 11192-11196 - 2007
Long Li, Shumin Li, Jianhao Sun, Lili Zhou, Xing‐Guo Bao, Honggang Zhang, Fusuo Zhang
Intercropping, which grows at least two crop species on the same pieces of land at the same time, can increase grain yields greatly. Legume–grass intercrops are known to overyield because of legume nitrogen fixation. However, many agricultural soils are deficient in phosphorus. Here we show that a new mechanism of overyielding, in which phosphorus mobilized by one crop species...... hiện toàn bộ
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