Proceedings of the National Academy of Sciences of the United States of America

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Superoxide dismutase is dispensable for normal animal lifespan
Proceedings of the National Academy of Sciences of the United States of America - Tập 109 Số 15 - Trang 5785-5790 - 2012
Jeremy M. Van Raamsdonk, Siegfried Hekimi
Reactive oxygen species (ROS) are toxic oxygen-containing molecules that can damage multiple components of the cell and have been proposed to be the primary cause of aging. The antioxidant enzyme superoxide dismutase (SOD) is the only eukaryotic enzyme capable of detoxifying superoxide, one type of ROS. The fact that SOD is present in all aerobic organisms raises the question ...... hiện toàn bộ
Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America - Tập 93 Số 18 - Trang 9782-9787 - 1996
Russell M. Lebovitz, Henggui Zhang, Hannes Vogel, Joiner Cartwright, Louise A. Dionne, Ning Lü, Shixia Huang, Martin M. Matzuk
Manganese superoxide dismutase (SOD2) converts superoxide to oxygen plus hydrogen peroxide and serves as the primary defense against mitochondrial superoxide. Impaired SOD2 activity in humans has been associated with several chronic diseases, including ovarian cancer and type I diabetes, and SOD2 overexpression appears to suppress malignancy in cultured cells. We have produced a line of SO...... hiện toàn bộ
Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity.
Proceedings of the National Academy of Sciences of the United States of America - Tập 86 Số 8 - Trang 2761-2765 - 1989
J. P. Phillips, Shelagh D. Campbell, Dominique Michaud, Michel Charbonneau, Arthur J. Hilliker
The role of copper/zinc-containing superoxide dismutase (cSOD; superoxide:superoxide oxidoreductase, EC 1.15.1.1) in metabolic defense against O2 toxicity in Drosophila is examined through the properties of a mutant strain carrying a cSOD-null mutation, cSODn108. Homozygotes are viable as larvae, which indicates that cSOD is not essential for cell viability per se. cSODn108 confers recessi...... hiện toàn bộ
RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stress
Proceedings of the National Academy of Sciences of the United States of America - Tập 99 Số 25 - Trang 16162-16167 - 2002
Kim Kirby, Jianguo Hu, Arthur J. Hilliker, J. P. Phillips
Oxidative stress has been widely implicated as an important factor in the aging process. Because mitochondrial respiration is the principal source of reactive oxygen within cells, the mitochondrially localized superoxide dismutase (SOD) 2 is thought to play an important front-line defensive role against aging-related oxidative stress. Although genetic studies with mutants defi...... hiện toàn bộ
Overexpression of Cu-Zn superoxide dismutase in Drosophila does not affect life-span.
Proceedings of the National Academy of Sciences of the United States of America - Tập 87 Số 11 - Trang 4270-4274 - 1990
Nina O.L. Seto, Shizu Hayashi, G. M. Tener
Aging and disease processes may be due to deleterious and irreversible changes produced by free radical reactions. The enzyme copper-zinc superoxide dismutase (Cu-Zn SOD; superoxide:superoxide oxidoreductase, EC 1.15.1.1) performs a protective function by scavenging superoxide radicals. The Cu-Zn SOD gene (Sod) cloned from Drosophila melanogaster was introduced via P element-mediated trans...... hiện toàn bộ
Targeted disruption of gene function in Drosophila by RNA interference (RNA-i): A role for nautilus in embryonic somatic muscle formation
Proceedings of the National Academy of Sciences of the United States of America - Tập 96 Số 4 - Trang 1451-1456 - 1999
Leonie Misquitta, Bruce M. Paterson
The expression of the MyoD gene homolog, nautilus (nau), in the Drosophila embryo defines a subset of mesodermal cells known as the muscle “pioneer” or “founder” cells. These cells are thought to establish the future muscle pattern in each hemisegment. Founders appear to re...... hiện toàn bộ
Global warming has increased global economic inequality
Proceedings of the National Academy of Sciences of the United States of America - Tập 116 Số 20 - Trang 9808-9813 - 2019
Noah S. Diffenbaugh, Marshall Burke
Significance We find that global warming has very likely exacerbated global economic inequality, including ∼25% increase in population-weighted between-country inequality over the past half century. This increase results from the impact of warming on annual economic growth, which over the course of decades has accumulated robust and substantial declines i...... hiện toàn bộ
Antisense inhibition of the p65 subunit of NF-kappa B blocks tumorigenicity and causes tumor regression.
Proceedings of the National Academy of Sciences of the United States of America - Tập 90 Số 21 - Trang 9901-9905 - 1993
Kimberly A. Higgins, José R. Perez, T A Coleman, Kenneth Dorshkind, Warren McComas, U M Sarmiento, C A Rosen, Ramaswamy Narayanan
The NF-kappa B transcription factor, composed of two proteins, p50 and p65, is a pleiotropic activator that participates in the induction of a wide variety of cellular genes. Various cell adhesion molecules have NF-kappa B binding sites and may play an important role in inflammatory response, tumorigenicity, and metastasis. In an earlier study, we demonstrated that adhesion of diverse tran...... hiện toàn bộ
Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
Proceedings of the National Academy of Sciences of the United States of America - Tập 99 Số 24 - Trang 15524-15529 - 2002
George A. Călin, Calin Dan Dumitru, Masayoshi Shimizu, Roberta Bichi, Simona Zupo, Evan Noch, Hansjuerg Aldler, Sashi Rattan, Michael J. Keating, R. Kanti, Laura Z. Rassenti, Thomas Enzler, Massimo Negrini, Florencia Bullrich, Carlo M. Croce
Micro-RNAs ( miR genes) are a large family of highly conserved noncoding genes thought to be involved in temporal and tissue-specific gene regulation. MiRs are transcribed as short hairpin precursors (≈70 nt) and are processed into active 21- to 22-nt RNAs by Dicer, a ribonuclease that recognizes target mRNAs via base-pairing ...... hiện toàn bộ
A sensory neuron-specific, proton-gated ion channel
Proceedings of the National Academy of Sciences of the United States of America - Tập 95 Số 17 - Trang 10240-10245 - 1998
Chih‐Cheng Chen, Steven England, Armen N. Akopian, John N. Wood
Proton-gated channels expressed by sensory neurons are of particular interest because low pH causes pain. Two proton-gated channels, acid-sensing ionic channel (ASIC) and dorsal root ASIC (DRASIC), that are members of the amiloride-sensitive ENaC/Degenerin family are known to be expressed by sensory neurons. Here, we describe the cloning and characterization of an ASIC splice variant, ASIC...... hiện toàn bộ
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