Biological reactions to wear debris in total joint replacement Tập 214 Số 1 - Trang 21-37 - 2000
Eileen Ingham, John Fisher
The vast majority of total hip prostheses currently implanted consist of a hard
metal or ceramic femoral head articulating against an ultra-high molecular
weight polyethylene (UHMWPE) acetabular cup. Over the last 10 years, evidence
has accumulated to show that these prostheses are prone to failure due to late
aseptic loosening and few survive beyond 25 years. With an increasing need to
implant hi... hiện toàn bộ
Bone grafting, orthopaedic biomaterials, and the clinical need for bone engineering Tập 224 Số 12 - Trang 1329-1343 - 2010
A S Brydone, Dominic Meek, Sarah Elizabeth Maclaine
As the population ages, the number of operations performed on bone is expected
to increase. Diseases such as arthritis, tumours, and trauma can lead to defects
in the skeleton requiring an operation to replace or restore the lost bone.
Surgeons can use autografts, allografts, and/or bone graft substitutes to
restore areas of bone loss. Surgical implants are also used in addition or in
isolation to... hiện toàn bộ
Knee joint forces: prediction, measurement, and significance Tập 226 Số 2 - Trang 95-102 - 2012
Darryl D. D’Lima, Benjamin J. Fregly, Shantanu Patil, Nikolai Steklov, Clifford W. Colwell
Knee forces are highly significant in osteoarthritis and in the survival and
function of knee arthroplasty. A large number of studies have attempted to
estimate forces around the knee during various activities. Several approaches
have been used to relate knee kinematics and external forces to internal joint
contact forces, the most popular being inverse dynamics, forward dynamics, and
static body ... hiện toàn bộ
The Role of the Quadriceps in Controlling Impulsive Forces around Heel Strike Tập 204 Số 1 - Trang 21-28 - 1990
R J Jefferson, James J. Collins, Michael W. Whittle, Eric L. Radin, John O’Connor
The damaging effect of transient loads on joints has been observed in vitro and
in vivo, and may be an aetiological factor in osteoarthrosis. The events around
heel strike, when the velocity of the foot is brought rapidly to zero, may be a
source of such loads in normal activity. By modifying the rate at which the limb
descends to the ground, quadriceps action influences the magnitude of the heel
... hiện toàn bộ
Biological effects of clinically relevant wear particles from metal-on-metal hip prostheses Tập 220 Số 2 - Trang 355-369 - 2006
C. E. Brown, John Fisher, Eileen Ingham
The problems of osteolysis and late aseptic loosening associated with ultra-high
molecular weight polyethylene (UHMWPE) particles has lead to a renewed interest
in metal-on-metal prostheses. Wear particles generated by modern Co-Cr-on-Co-Cr
prostheses are nanometre in size (range: 10-120 nm; mean: about 40 nm), an order
of magnitude smaller than the size of UHMWPE known to be critical for activati... hiện toàn bộ
Comparison of different methods for estimating muscle forces in human movement Tập 226 Số 2 - Trang 103-112 - 2012
Yi‐Chung Lin, Tim W. Dorn, Anthony G. Schache, Marcus G. Pandy
The aim of this study was to compare muscle-force estimates derived for human
locomotion using three different methods commonly reported in the literature:
static optimisation (SO), computed muscle control (CMC) and neuromusculoskeletal
tracking (NMT). In contrast with SO, CMC and NMT calculate muscle forces
dynamically by including muscle activation dynamics. Furthermore, NMT utilises a
time-depe... hiện toàn bộ
Mass–spring–damper modelling of the human body to study running and hopping – an overview Tập 225 Số 12 - Trang 1121-1135 - 2011
Ali Asadi Nikooyan, Amir A. Zadpoor
Several mass–spring–damper models have been developed to study the response of
the human body to the collision with the ground during hopping, trotting, or
running. The mass, spring, and damper elements represent the masses, stiffness
properties, and damping properties of hard and soft tissues. The masses that
models are composed of are connected to each other via springs and dampers. The
present ... hiện toàn bộ
Strain distribution in the proximal human femoral metaphysis Tập 223 Số 3 - Trang 273-288 - 2009
Luca Cristofolini, Mateusz Juszczyk, Fulvia Taddei, Marco Viceconti
There is significant interest in the stress—strain state in the proximal femoral
metaphysis, because of its relevance for hip fractures and prosthetic
replacements. The scope of this work was to provide a better understanding of
the strain distribution, and of its correlation with the different directions of
loading, and with bone quality. A total of 12 pairs of human femurs were
instrumented with... hiện toàn bộ
Metal-on-metal hip simulator study of increased wear particle surface area due to ‘severe’ patient activity Tập 220 Số 2 - Trang 279-287 - 2006
John G. Bowsher, A. Hussain, Paul A. Williams, Julia C. Shelton
This study investigated changes in metal-on-metal (MOM) hip wear and wear
particle characteristics arising from a more aggressive patient activity level
compared with normal walking. The test hypothesis was that ‘severe’-gait
conditions will change wear, wear particle sizes, and morphology owing to a
decline in joint lubrication. Four carbon MOM hip bearings 40 mm high were
subjected to normal-wal... hiện toàn bộ
Wear and biological activity of highly crosslinked polyethylene in the hip under low serum protein concentrations Tập 221 Số 1 - Trang 1-10 - 2007
Alison L. Galvin, Joanne L. Tipper, Louise M. Jennings, M H Stone, Zhongmin Jin, Eileen Ingham, J. Fisher
Crosslinked ultra-high molecular weight polyethylene (UHMWPE) has been developed
and introduced into clinical practice in order to reduce wear in the hip. Zero
wear of highly crosslinked UHMWPE in vitro has been reported by some groups
using lubricants with high concentrations of serum proteins in hip simulators.
In contrast, some clinical studies have reported finite wear rates. The aim of
this s... hiện toàn bộ