Biological effects of clinically relevant wear particles from metal-on-metal hip prostheses

Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine - Tập 220 Số 2 - Trang 355-369 - 2006
C. E. Brown1, John Fisher2, Eileen Ingham2
1Institute of Medical and Biological Engineering, School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, UK. [email protected]
2Institute of Medical and Biological Engineering, University of Leeds, Leeds, UK

Tóm tắt

The problems of osteolysis and late aseptic loosening associated with ultra-high molecular weight polyethylene (UHMWPE) particles has lead to a renewed interest in metal-on-metal prostheses. Wear particles generated by modern Co-Cr-on-Co-Cr prostheses are nanometre in size (range: 10-120 nm; mean: about 40 nm), an order of magnitude smaller than the size of UHMWPE known to be critical for activation of osteolytic cytokines by macrophages. Co-Cr wear particles will induce osteolytic cytokine production by human macrophages, but only at high volumetric concentrations. Unlike UHMWPE, Co-Cr particles are not inert. Co-Cr particles have the potential to release metal ions; they may be toxic to cells, induce deoxyribonucleic acid damage or cause host hypersensitivity. The nanometre size range of Co-Cr wear particles means that they may be disseminated widely in the body. The potential for metal-on-metal bearings to induce adverse effects clinically will be dependent upon the rate of wear. What constitutes a safe wear rate for modern metal-on-metal bearings is unknown. However, the wear of metal-on-metal prostheses is critically dependent upon the design and, in particular, the carbon content of the alloy, the radial clearance, and the head diameter. Thus, the potential for adverse biological reactions associated with metal-on-metal bearings can be reduced by selection of appropriately designed implants.

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Tài liệu tham khảo

10.1097/00003086-199608001-00006

10.1097/00003086-199608001-00027

Fisher J., 2000, Metasul: A Metal-on-metal Bearing, 121

10.1097/00003086-199608001-00003

10.1520/STP12836S

Müller M. E., 1995, Clin. Orthop. Rel. Res., 311, 54

10.1016/j.biomaterials.2004.04.035

10.1243/0954411001535219

10.2106/00004623-199072040-00008

10.1243/0954411971534304

10.1023/A:1008901302646

Bell J., 2002, Biomed. Mater. Engng, 12, 189

10.1002/1097-4636(200009)53:5<490::AID-JBM7>3.0.CO;2-7

10.1002/1097-4636(200011)52:2<296::AID-JBM8>3.0.CO;2-9

10.1016/S0142-9612(98)00140-9

10.1016/S0142-9612(00)00089-2

10.1097/00003086-199608001-00004

10.1302/0301-620X.81B1.9047

10.1243/0954411001535381

10.1002/1097-4636(20010605)55:3<320::AID-JBM1020>3.0.CO;2-3

10.1002/1097-4636(20010605)55:3<330::AID-JBM1021>3.0.CO;2-Y

10.1302/0301-620X.74B3.1587882

10.1302/0301-620X.76B5.8083255

10.1097/00003086-199608001-00016

10.1097/00003086-199608001-00017

10.1097/00003086-199705000-00029

10.1097/00003086-199608001-00018

10.1002/(SICI)1097-4636(199810)42:1<103::AID-JBM13>3.0.CO;2-M

Firkins P.J., 2001, Biomed. Mater. Engng, 11, 143

Brown C., Tipper J. L., Fisher J., Ingham E. Use of high resolution microscopy to characterise wear debris produced by metal-on-metal hip simulation. In 50th Annual Meeting, Orthopaedic Research Society, San Francisco, California, 7–10 March 2004, paper 1512.

10.1002/jbm.b.30132

10.1002/(SICI)1097-4636(19991215)47:4<543::AID-JBM11>3.0.CO;2-G

10.1302/0301-620X.85B5.13729

10.1302/0301-620X.57B4.444

10.1038/icb.1983.34

10.1016/0142-9612(94)90170-8

Mostardi R. A., Meerbaum S. O., Kovacik M. W., Gradisar I. A. Cell culture response of synovial fibroblasts to prosthetic metal particles. In Proceedings of the Fifth World Biomaterials Congress, Toronto, Canada, 28 May-2 June 1996, p. 855.

10.1002/(SICI)1097-4636(199606)31:2<183::AID-JBM4>3.0.CO;2-J

10.1016/S0142-9612(02)00360-5

Hu X. Q., 2004, Biomed. Mater. Engng, 14, 145

Jin Z. M., Medley J. B., Dowson D. Fluid film lubrication in artificial hip joints. In Proceedings of the 29th Leeds-Lyon Symposium on Tribology, Leeds, 3–6 September 2003, pp. 237–256 (Elsevier, Amsterdam).

10.1097/00003086-199608001-00005

10.1097/00003086-200105000-00020

10.1016/j.arth.2004.02.039

10.1016/S0883-5403(08)80093-9

Campbell P. A., 2001, World Tribology Forum in Arthroplasty, 167

10.1016/S0142-9612(02)00351-4

Bendall S. P., Radfar A. J., Jinnah R. H., Hungerford D. S. Metallic wear debris from periprosthetic tissue of failed arthroplasty induces TNF-α and IL-lα release from synoviocytes. In Proceedings of the Fifth World Biomaterials Congress, Toronto, Canada, 28 May-2 June 1996, p. 546.

10.1002/(SICI)1097-4636(19980905)41:3<468::AID-JBM17>3.0.CO;2-E

10.1016/S0142-9612(00)00181-2

10.1016/S0161-5890(99)00127-3

Jacobs J. J., 2003, Clin. Orthop. Rel. Res., 417, 139, 10.1097/01.blo.0000096810.78689.62

Jacobs J. J., 1995, Clin. Orthop. Rel. Res., 319, 94

10.1097/00003086-199605000-00009

10.4049/jimmunol.172.3.1926

10.2106/00004623-200103000-00017

10.1002/(SICI)1097-4636(20000305)49:3<353::AID-JBM8>3.0.CO;2-T

10.1136/bmj.4.5993.374

10.1034/j.1600-0536.2003.480108_4.x

10.1046/j.1365-2133.2003.05404.x

10.1016/S0736-0266(03)00186-4

Willert H.G., Buchhorn G. H., Fayyazi A. Hypersensitivity around metal/metal hips? In Proceedings of the Second International Conference on Metal-Metal Hip Prostheses: Past Performance and Future Directions, Montreal, Canada, 2003.

10.2106/00004623-200501000-00006

10.2106/00004623-200501000-00005

10.1136/oem.58.10.619

10.1007/BFb0111319

10.1080/02772248709357191

10.1023/A:1015975218920

Singh J., 1998, Oncol. Rep., 5, 1307

10.1093/toxsci/55.1.60

10.1002/1098-2744(200006)28:2<111::AID-MC7>3.0.CO;2-Y

10.1023/A:1017958028256

10.1093/carcin/21.11.2027

10.1093/carcin/21.4.533

10.1302/0301-620X.70B4.3403594

10.1097/00003086-199608001-00025

10.1097/00003086-199608001-00024

10.2106/00004623-200004000-00002

10.1302/0301-620X.83B7.10102

10.1002/jbm.b.10070

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Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine

Tập 220 Số 2

355-369

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