Yu. D. Ivanov, V. V. Danichev, Tatyana O. Pleshakova, Ivan D. Shumov, Vadim S. Ziborov, N. V. Krokhin, M. N. Zagumenniy, V. S. Ustinov, Л. П. Смирнов, A. V. Shironin, Alexander I. Archakov
Ubiquitination is a type of intracellular proteins post-translational modification (PTM) characterized by covalent attachment of ubiquitin molecules to target proteins. This includes monoubiquitination (attachment of one ubiquitin molecule), multiple monoubiquitination also known as multiubiquitination (attachment of several monomeric ubiquitin molecules to a target protein), and polyubiquitinatio...... hiện toàn bộ
V. K. Gorodetskii, A. I. Tochilkin, N. F. Belayeva, I. R. Kovelman, B. F. Korovkin
In order to create new oral vanadyl organic complexes-based drugs for the treatment of diabetes mellitus we have originally synthesized a biligand vanadyl derivative of L-malic acid (bis(L-malato)oxovanadium(IV)) and investigated its potential as a novel hypoglycemic agent using the experimental streptozotocin-induced diabetes in rats. The oral administration of bis(L-malato)oxovanadium(IV) with d...... hiện toàn bộ