Yu. D. Ivanov, V. V. Danichev, Tatyana O. Pleshakova, Ivan D. Shumov, Vadim S. Ziborov, N. V. Krokhin, M. N. Zagumenniy, V. S. Ustinov, Л. П. Смирнов, A. V. Shironin, Alexander I. Archakov
Ubiquitination is a type of intracellular proteins post-translational
modification (PTM) characterized by covalent attachment of ubiquitin molecules
to target proteins. This includes monoubiquitination (attachment of one
ubiquitin molecule), multiple monoubiquitination also known as
multiubiquitination (attachment of several monomeric ubiquitin molecules to a
target protein), and polyubiquitinatio... hiện toàn bộ
V. K. Gorodetskii, A. I. Tochilkin, N. F. Belayeva, I. R. Kovelman, B. F. Korovkin
In order to create new oral vanadyl organic complexes-based drugs for the
treatment of diabetes mellitus we have originally synthesized a biligand vanadyl
derivative of L-malic acid (bis(L-malato)oxovanadium(IV)) and investigated its
potential as a novel hypoglycemic agent using the experimental
streptozotocin-induced diabetes in rats. The oral administration of
bis(L-malato)oxovanadium(IV) with d... hiện toàn bộ