Synthesis and hypoglycemic activity of Bis(L-malato)oxovanadium(IV)

Pleiades Publishing Ltd - Tập 5 - Trang 260-262 - 2011
V. K. Gorodetskii1, A. I. Tochilkin1, N. F. Belayeva1, I. R. Kovelman1, B. F. Korovkin1
1Institute of Biomedical Chemistry, Moscow, Russia

Tóm tắt

In order to create new oral vanadyl organic complexes-based drugs for the treatment of diabetes mellitus we have originally synthesized a biligand vanadyl derivative of L-malic acid (bis(L-malato)oxovanadium(IV)) and investigated its potential as a novel hypoglycemic agent using the experimental streptozotocin-induced diabetes in rats. The oral administration of bis(L-malato)oxovanadium(IV) with drinking water significantly reduced blood and urinary glucose concentrations and also the level of glycated proteins in the streptozotocin-diabetic rats.

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Pleiades Publishing Ltd

Tập 5

260-262

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