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Assessment of the Effect of Age, Renal Function Status, and M-Cholinoblocker Biperidene Intake on Free Plasma Choline Concentrations
Pleiades Publishing Ltd - - 2024
E. I. Savelieva, M. A. Leninsky, N. V. Goncharov
The use of high-performance liquid chromatography in combination with tandem mass spectrometry (HPLC-MS/MS) provides a selective determination of free choline in blood plasma. The instability of the measurement results is due to the residual activity of phospholipases that promote the hydrolysis of phosphatidylcholine ex vivo. The use of EDTA as an anticoagulant and compliance with the cold regime...... hiện toàn bộ
The effect of myosin ATPase inhibition on metabolic and functional recovery of isolated rat heart after global ischemia
Pleiades Publishing Ltd - Tập 3 - Trang 289-294 - 2009
O. I. Pisarenko, V. S. Shulzhenko, I. M. Studneva
The effect of myosin ATPase inhibitor, 2,3-butanedione monoxime (BDM) used in the range of concentrations 1.25–10.0 mM), on recovery of functions of isolated rat heart subjected to normothermic (37 °C) total ischemia for 35 min has been investigated. BDM perfusion was performed at a flow rate of 4 ml/min during 5 min before ischemia (BDM-I) or before 25-min reperfusion (BDM-R). Control hearts were...... hiện toàn bộ
Apoptotic endonuclease EndoG regulates alternative splicing of human telomerase catalytic subunit hTERT
Pleiades Publishing Ltd - - 2017
D. D. Zhdanov, D. A. Vasina, E. V. Orlova, V. S. Orlova, M. V. Pokrovskaya, S. S. Aleksandrova, N. N. Sokolov
Human telomerase catalytic subunit hTERT is subjected to alternative splicing results in loss of its function and leads to decrease of telomerase activity. However, very little is known about the mechanism of hTERT pre-mRNA alternative splicing. Apoptotic endonuclease EndoG is known to participate this process. The aim of this study was to determine the role of EndoG in regulation of hTERT alterna...... hiện toàn bộ
Antibodies against modified low-density lipoproteins and their complexes in blood of patients with various manifestations of atherosclerosis
Pleiades Publishing Ltd - - 2016
Ia V Belik, A. A. Ivantsova, Z. E. Mamedova, A. D. Denisenko
Biochemical markers predicting response to radiation- and radiochemo-therapy in cancer patients
Pleiades Publishing Ltd - Tập 7 - Trang 212-221 - 2013
S. D. Ivanov
Ongoing studies carried out worldwide using banks of tumor and non-tumor samples give evidence that perspective markers predicting response of individual patients to intended radiation therapy may be found among some apoptotic indexes, spectrum of specialized proteins, and DNA-based microarray molecular profiling analysis as well determination of single nucleotide polymorphisms in genome of the pa...... hiện toàn bộ
Myeloperoxidase Exocytosis from Activated Neutrophils in the Presence of Heparin
Pleiades Publishing Ltd - Tập 12 - Trang 136-142 - 2018
D. V. Grigorieva, I. V. Gorudko, V. A. Kostevich, V. B. Vasilyev, S. N. Cherenkevich, O. M. Panasenko, A. V. Sokolov
Exocytosis of myeloperoxidase (MPO) from activated neutrophils has been investigated in the presence of the anionic polysaccharide heparin. The optimal concentration of heparin (0.1 U/mL), which did not cause additional activation of cells (lack of augmentation of lysozyme exocytosis from specific and azurophilic granules), was determined. After preincubation of cells with heparin (0.1 U/mL) MPO e...... hiện toàn bộ
Hepatotoxic effects of acetaminophen. Protective properties of tryptophan derivatives
Pleiades Publishing Ltd - Tập 4 - Trang 264-268 - 2010
I. K. Dremza, V. T. Cheshchevik, S. V. Zabrodskaya, Yu. Z. Maksimchik, E. Yu. Sudnikovich, E. A. Lapshina, I. B. Zavodnik
Rat intoxication with acetaminophen (APAP) (500–1500 mg/kg body weight, intragastrically) caused a considerable dose-dependent decrease in reduced glutathione (GSH) level in both liver cell cytoplasm and mitochondria (at the dose 1500 mg/kg body weight by 60% and 33%, respectively). The decrease in cytoplasmic GSH level was more pronounced than in mitochondria. Despite of significant mitochondrial...... hiện toàn bộ
Mechanisms of attenuation of ischemic heart injury by means of a modified reperfusion
Pleiades Publishing Ltd - Tập 1 Số 4 - Trang 313-318 - 2007
О. И. Писаренко, И. М. Студнева, V. S. Shulzhenko, А. А. Тимошин
Application of PEG-chitosan copolymers for regulation of catalytic properties of enzymes for medical application using recombinant Erwinia carotovora L-asparaginase as an example
Pleiades Publishing Ltd - Tập 8 - Trang 252-259 - 2014
E. V. Kudryashova, K. V. Sukhoverkov, N. N. Sokolov
A new approach to the regulation of catalytic properties of medically relevant enzymes has been proposed using the novel recombinant preparation of L-asparaginase from Erwinia carotovora (EwA), a promising antitumor agent. New branched co-polymers of different composition based on chitosan modified with polyethylene glycol (PEG) molecules, designated as PEG-chitosan, have been synthesized. PEG-chi...... hiện toàn bộ
Quantitative Proteomics of Human Blood Exosomes
Pleiades Publishing Ltd - Tập 13 - Trang 132-139 - 2019
N. A. Shushkova, N. E. Vavilov, S. E. Novikova, T. E. Farafonova, O. V. Tikhonova, P.-C. Liao, V. G. Zgoda
Exosomes are extracellular membrane vesicles secreted by cells into biological fluids. The membrane of exosomes protects their contents from degradation and contains markers of the cells producing them. Almost all cells of the body produce exosomes, however, tumor cells secrete them more intensively. However, initial stages of the study of exosome functions and identification of tumor protein biom...... hiện toàn bộ
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