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Synthesis of Unsymmetrically Substituted Succinic Acid Diamides Containing a Pharmacophoric 2-Aminopyrimidine Fragment as Potential Protein Kinase Inhibitors
Pleiades Publishing Ltd - Tập 59 - Trang 2167-2175 - 2024
E. V. Koroleva, Zh. V. Ignatovich, A. L. Ermolinskaya, J. V. Siniutsich, O. V. Panibrat
Succinic acid diamides containing two pharmacophoric fragments, one of which is 2amino­pyrimidine, and the other, N-methylpiperazine, 2-aminopyrimidine, or substituted aniline moiety, were synthesized in two steps. The synthetic scheme included acylation of substituted (pyrimidin-2-ylamino)aniline or pyrimidin-2-amine with succinic anhydride and the subsequent acylation of another heterocyclic or ...... hiện toàn bộ
Reactions of Indole and Its Derivatives with Cotarnine. Rearrangement of 5-(1-Indolyl)-4-methoxy-6-methyl- 5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolines
Pleiades Publishing Ltd - Tập 38 - Trang 430-436 - 2002
K. A. Krasnov, V. G. Kartsev
A synthetic route to compounds of the indolyltetrahydroisoquinoline series was developed on the basis of the reaction of cotarnine with indole derivatives. Aminoalkylation of indole and its derivatives with cotarnine occurs regioselectively at the nitrogen atom of the indole fragment to give the corresponding 5-(1-indolyl)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolines. The ...... hiện toàn bộ
4-Alkyl-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octanes in the Synthesis of Lipids
Pleiades Publishing Ltd - Tập 40 - Trang 1064-1064 - 2004
G. A. Savin, O. M. Kutsemako
Synthesis and properties of [4-(triphenylmethyl)phenoxy]acetic and 3-[4-(triphenylmethyl)phenoxy]propionic acids and their condensation with phthalimide leading to meso-substituted tetrabenzoporphyrins
Pleiades Publishing Ltd - Tập 45 - Trang 1024-1030 - 2009
N. E. Galanin, L. A. Yakubov, G. P. Shaposhnikov
Condensation of 4-(triphenylmethyl)phenol with monochloroacetic and 3-bromopropionic acids gave, respectively, [4-(triphenylmethyl)phenoxy]acetic and 3-[4-(triphenylmethyl)phenoxy]propionic acids which reacted with phthalimide in the presence of zinc acetate to produce meso-substituted zinc tetrabenzoporphyrins having bulky triphenylmethyl groups in the substituent. The corresponding free ligands ...... hiện toàn bộ
Approaches to Epothilone Carboanalogs Starting from Δ3-Carene
Pleiades Publishing Ltd - Tập 39 - Trang 75-81 - 2003
F. A. Akbutina, I. F. Sadretdinov, O. M. Kuznetsov, E. V. Vasil'eva, M. S. Miftakhov
Starting from (+)-Δ3-carene, synthetic equivalents of the C10-C16 fragment of epothilone carbo- analogs were obtained.
Kinetics and mechanism of reaction between polyfluorinated alcohols and thionyl chloride
Pleiades Publishing Ltd - Tập 40 - Trang 1579-1582 - 2004
A. I. Rakhimov, Yu. V. Popov, V. M. Volchkov, O. V. Vostrikova, E. A. Zauer
Complexing of polyfluorinated alcohols with triethylamine was studied by means of microcalorimetry, IR and NMR spectroscopy. The reaction kinetics of these polar complexes with thionyl chloride was investigated using calorimetry of heat fluxes applying mathematical simulation procedure. The second order of nucleophilic substitution reaction of chlorine by polyfluoroalkoxy group was established.
Thermal, acid-catalyzed, and photolytic transformations of spirocyclic 3H-pyrazoles formed by reactions of methyl, phenyl, and p-tolyl phenylethynyl sulfones with 9-diazofluorene
Pleiades Publishing Ltd - Tập 50 - Trang 1323-1334 - 2014
V. A. Vasin, Yu. Yu. Masterova, V. V. Razin, N. V. Somov
Methyl, phenyl, and p-tolyl phenylethynyl sulfones react with 9-diazofluorene in diethyl ether at 20°C to give 1,3-dipolar cycloaddition products according to von Auwers’ rule, the corresponding spirocyclic 3H-pyrazoles. The spiro adducts undergo isomerization into 5-R-sulfonyl-3-phenylpyrazolo[1,5-f]phenanthridines on heating in boiling toluene for 2 h; heating of the same pyrazoles in boiling be...... hiện toàn bộ
New method of synthesis of 2-arylindoles and naphtho[1,2-d]imidazoles
Pleiades Publishing Ltd - Tập 49 Số 8 - Trang 1244-1245 - 2013
A. S. Lyakhovnenko, Т. С. Редько, И. В. Аксенова, Nicolai A. Aksenov, А. В. Аксенов
Synthesis of ethyl (±)-(13,15-dideoxy)-16-methyl-9-oxoprosta-13(E,Z),15(E)-dienoate
Pleiades Publishing Ltd - Tập 46 - Trang 1301-1304 - 2010
N. S. Vostrikov, V. V. Loza, N. A. Ivanova, M. S. Miftakhov
The condensation of ethyl 7-(2-oxo-5-formulcyclopentyl)heptanoate by Wittig reaction with the ylide prepared from [(2E)-3-methylhept-2-en-1-yl]triphenylphosphonium bromide afforded ethyl (±)-(13,15-dideoxy)-16-methyl-9-oxoprosta-13(E,Z),15(E)-dienoate as a mixture of two isomers, 2:1.
Structure of indoline spiropyrans containing a fused coumarin fragment: Quantum-chemical investigation
Pleiades Publishing Ltd - Tập 47 - Trang 1742-1745 - 2011
A. D. Dubonosov, O. G. Nikolaeva, A. V. Tsukanov, A. G. Starikov, V. A. Bren’, V. I. Minkin
In order to examine the way of fusion of the coumarin fragment to the 2H-pyran part of indoline spiropyrans the relative stability was estimated of the cyclic and merocyanine forms by means of calculations in the framework of DFT in B3LYP/6-31G(d,p) approximation. In agreement with the experimental data the relative stabilization of the spirocyclic isomer correlates with the length of the bond whe...... hiện toàn bộ
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