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Suzuki cross-coupling was used for modification of 3-polyfluoroalkyl-1-phenylpyrazoles at the position C4. The synthesized 4-bromo- and 4-phenyl derivatives showed antitubercular effect on pyrazinamide level.

Cyclocondensation of 3-amino-5-methylpyrazole with 2-arylmethylidene-5,5-dimethylcyclohexane-1,3-diones or 9-aryl-3,3,6,6-tetramethyl-2,3,4,5,6,7,8,9-octahydro-1H-xanthene-1,8-diones, as well as with synthetic precursors of the latter (para-substituted benzaldehydes and dimedone), in dimethylformamide or methanol gives the corresponding 4-aryl-3,7,7-trimethyl-2,4,6,7,8,9-hexahydropyrazolo[3,4-b]quinolin-5-ones. The structure of 4-(4-methoxyphenyl)-3,7,7-trimethyl-2,4,6,7,8,9-hexahydropyrazolo[3,4-b]quinolin-5-one was proved by the X-ray diffraction data.

Rotational surfaces for 13C-13C coupling constants with respect to two dihedral angles at C1 and C2 in model structures of aldopyranoses, aldofuranoses, and aldoseptanoses of the D-series were calculated in terms of the self-consistent finite perturbation theory. Internal rotation of the hydroxy groups exerts an appreciable effect (within 2.5 Hz) on the 13C-13C coupling constants of all cyclic forms of monosaccharides, which provides the possibility for performing conformational analysis of carbohydrates and their metabolites containing pyranose, furanose, and septanose fragments.

Reactions of 2,6-disubstituted 1,4,3,5-octathiadiazine-4,4-dioxides with cyano-containing compounds (nitriles, thiocyanates, N,N-disubstituted cyanamides) proceeding with replacement of imine fragment in dioxide by corresponding fragment of cyanide were investigated. The limits of the reaction were revealed determined by electronic effects of substituents R1 and R2 in dioxide and R3 in cyanide. Transimination occurred in dioxides with strong electron-withdrawing substituents R1 (CCl3, CBr3, C6F5) and weak acceptor or donor substituents R2(4-NO2C6H4, 4-ClC6H4, CH3) under the action of compounds R3C≡N with cyano groups of relatively high nucleophilicity (R3 = 4-ClC6H4, C6H5, (CH3)2CHS, piperidino, morpholino, diethylamino), on the one hand, and with strong electron-withdrawing substituents R3 (CCl3) on the other hand.

Reactions of 6-allylsulfanylpyrazolo[3,4-d]pyrimidin-4(5H)-one with arenesulfenyl chlorides in chloroform gave products of addition of the latter at the exocyclic double bond, while analogous reactions in acetic acid in the presence of LiClO4 were accompanied by intramolecular electrophilic cyclization involving the N7 atom. 6-Cinnamylsulfanylpyrazolo[3,4-d]pyrimidin-4(5H)-one reacted with arenesulfenyl chlorides in acetic acid in the absence of electrolyte to produce fused pyrazolo[4′,3′: 5,6]pyrimido[2,1-b][1,3]thiazine derivatives. Introduction of a bulky phenyl group into position 1 of the pyrazolo[3,4-d]pyrimidine system reduces the yield of the corresponding intramolecular cyclization product at N7 as a result of concurrent formation of acyclic addition product. DOI

By the reaction of N-alkyl- and N-arylimidazoles with 30-bromo-3,28-diacetoxylup-20(29)-ene a series was synthesized of unsymmetrically substituted chiral imidazolium bromides with a lupane fragment.

Recyclization of 4-arylamino-2-tert-butyl-5-oxo-2,5-dihydrofuran-2-yl acetates with ethyl cyanoacetate in the presence of triethylamine afforded the corresponding ethyl 2-amino-1-aryl-5-(3,3-dimethyl-2-oxobutylidene)-4-oxo-1H-4,5-dihydropyrrole-3-carboxylates.

According to the results of ab initio quantum-chemical calculation 1-bis(dimethylamino)-4-bis(trimethylsilyl-2,3-diphosphabuta-1,3-diene exists as an E-isomer where electronic delocalization occurs involving donor dimethylamino and acceptor trimethylsilyl groups and also the multiple P = C bonds.

A preparative procedure has been proposed for the alkylation of CH acids with halo acetals and hydrolysis of the alkylation products to furan derivatives and lactones.

A procedure was developed for preparation of methyl 5(6)-(4-aminophenoxy)- and 5(6)-(2-aminophenoxy)-2-benzimidazolyl carbamates by reaction of 3,4,4`-triaminodiphenyl or 3,4,2`-triaminodiphenyl ethers respectively with methyl cyanocarbamate in water solution in the presence of 7-10 molar excess of acetic acid. The helminthicidal properties, embryotoxicity, and overall toxicity of compounds obtained were estimated.