Urotropin synthesis of 3,5-di-tert-butylsalicylic acid derivatives
Tóm tắt
The stability of 3,5-di-tert-butylsalicylic aldehyde against oxidation is due to autoinhibiting of the chain process. However its oxidation into 3,5-di-tert-butylsalicylic acid was performed at the use of acetyl protection of the hydroxy group. In reaction of 6-bromo-2,4-di-tert-butylphenol with urotropin the formation was discovered of 3,5-di-tert-butylsalicylic acid, its nitrile and amide.
Tài liệu tham khảo
Belostotskaya, I.S., Komicsarova, N.L., Prokof’eva, T.I., Kurkovskaya, L.N., and Vol’eva, V.B., Zh. Org. Khim., 2005, vol. 41, p. 718.
Turney, T.A., Oxidation Mechanisms, Washington: Butterworths, 1965.
Scheurer, A., Mosset, P., and Bauer, W., Eur. J. Org. Chem., 2001, vol. 16, p. 3067.
Tashiro, M., Joshiya, H., and Fukata, G., J. Chem. Soc., Chem. Commun., 1980, p. 495.
Belostotskaya, I.S., Vol’eva, V.B., Komissarova, N.L., Dekaprilevich, M.O., Khrustalev, V.N., Karmilov, A.Yu., and Ershov, V.V., Izv. Akad. Nauk, Ser. Khim., 1997, p. 1328.