Pigment Cell and Melanoma Research

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The exocyst is required for melanin exocytosis from melanocytes and transfer to keratinocytes
Pigment Cell and Melanoma Research - Tập 33 Số 2 - Trang 366-371 - 2020
Hugo Moreiras, Francisco J.C. Pereira, Matilde V. Neto, Liliana Bento‐Lopes, Tiago C. Festas, Miguel C. Seabra, Duarte C. Barral
AbstractSkin pigmentation involves the production of the pigment melanin by melanocytes, in melanosomes and subsequent transfer to keratinocytes. Within keratinocytes, melanin polarizes to the apical perinuclear region to form a protective cap, shielding the DNA from ultraviolet radiation‐induced damage. Previously, we found evidence to support the exocytosis by melanocytes of the melanin core, te... hiện toàn bộ
Nghiên cứu liên kết toàn bộ bộ gen xác định CDH13 là một gen dễ bị mắc bệnh bạch biến gây ra bởi rhododendrol Dịch bởi AI
Pigment Cell and Melanoma Research - Tập 33 Số 6 - Trang 826-833 - 2020
Ken Okamura, Yuko Abe, Izumi Naka, Jun Ohashi, Akiko Yagami, Kayoko Matsunaga, Yuri Kobayashi, Kazuyoshi Fukai, Atsushi Tanemura, Ichiro Katayama, Yukiko Masui, Akiko Ito, Toshiharu Yamashita, Hiroshi Nagai, Chikako Nishigori, Naoki Oiso, Yumi Aoyama, Yuta Araki, T. Saito, Masahiro Hayashi, Yasukazu Hozumi, Tamio Suzuki
Tóm tắtRS‐4‐(4‐hydroxyphenyl)‐2‐butanol dạng racemic (rhododendrol; tên thương mại: Rhododenol [RD]), được sử dụng trong mỹ phẩm làm trắng da, đã gây bất ngờ ở Nhật Bản khi báo cáo gây ra bạch biến hoặc bệnh bạch tạng gọi là bạch biến do rhododendrol (RIL) sau khi sử dụng nhiều lần. Theo hiểu biết của chúng tôi, chưa có nghiên cứu nào điều tra cơ chế gây bệnh bạch biến do hóa chất trên quy mô toàn... hiện toàn bộ
#GWAS #RIL #CDH13 #bạch biến #rhododendrol #tyrosinase #hóa cảm #T-cadherin #tự hủy
Use of permanent hair dyes and risk of vitiligo in women
Pigment Cell and Melanoma Research - Tập 28 Số 6 - Trang 744-746 - 2015
Shaowei Wu, Wenqing Li, Eunyoung Cho, John E. Harris, Frank E. Speizer, Abrar A. Qureshi
Revised classification/nomenclature of vitiligo and related issues: the Vitiligo Global Issues Consensus Conference
Pigment Cell and Melanoma Research - Tập 25 Số 3 - 2012
Khaled Ezzedine, Henry W. Lim, Tamio Suzuki, Ichiro Katayama, Iltefat Hamzavi, C. Lan, Boon Kee Goh, Tag S. Anbar, Carla Castro, Azalea Lee, Davinder Parsad, Nanja van Geel, I. Caroline Le Poole, Naoki Oiso, Laïla Benzekri, Richard A. Spritz, Yvon Gauthier, Seung Kyung Hann, Mauro Picardo, Alain Taı̈eb
SummaryDuring the 2011 International Pigment Cell Conference (IPCC), the Vitiligo European Taskforce (VETF) convened a consensus conference on issues of global importance for vitiligo clinical research. As suggested by an international panel of experts, the conference focused on four topics: classification and nomenclature; definition of stable disease; definition of Koebner’s phenomenon (KP); and... hiện toàn bộ
Novel MITF targets identified using a two‐step DNA microarray strategy
Pigment Cell and Melanoma Research - Tập 21 Số 6 - Trang 665-676 - 2008
Keith S. Hoek, Natalie C. Schlegel, Ossia M. Eichhoff, Daniel Widmer, Christian Praetorius, Steingrimur O. Einarsson, Sigrídur Valgeirsdóttir, Kristín Bergsteinsdóttir, Alexander Schepsky, Reinhard Dummer, Eirı́kur Steingrı́msson
SummaryMalignant melanoma is a chemotherapy‐resistant cancer with high mortality. Recent advances in our understanding of the disease at the molecular level have indicated that it shares many characteristics with developmental precursors to melanocytes, the mature pigment‐producing cells of the skin and hair follicles. The development of melanocytes absolutely depends on the action of the micropht... hiện toàn bộ
Re‐evaluation of insect melanogenesis research: Views from the dark side
Pigment Cell and Melanoma Research - Tập 30 Số 4 - Trang 386-401 - 2017
Miranda M. A. Whitten, Christopher J. Coates
SummaryMelanins (eumelanin and pheomelanin) are synthesized in insects for several purposes including cuticle sclerotization and color patterning, clot formation, organogenesis, and innate immunity. Traditional views of insect immunity detail the storage of pro‐phenoloxidases inside specialized blood cells (hemocytes) and their release upon recognition of foreign bodies. Activated phenoloxidases c... hiện toàn bộ
Identification of unique sensitizing targets for anti‐inflammatory CDDO‐Me in metastatic melanoma by a large‐scale synthetic lethal RNAi screening
Pigment Cell and Melanoma Research - Tập 26 Số 1 - Trang 97-112 - 2013
Yong Qin, Wuguo Deng, Sühendan Ekmekçioğlu, Elizabeth A. Grimm
SummaryCDDO‐Me has been shown to exert potent anti‐inflammatory activity for chronic kidney disease and antitumor activity for several tumors, including melanoma, in early clinical trials. To improve CDDO‐Me response in melanoma, we utilized a large‐scale synthetic lethal RNAi screen targeting 6000 human druggable genes to identify targets that would sensitize melanoma cells to CDDO‐Me. Based on s... hiện toàn bộ
Sex‐linked barring in chickens is controlled by the CDKN2A /B tumour suppressor locus
Pigment Cell and Melanoma Research - Tập 23 Số 4 - Trang 521-530 - 2010
Anders R. Hellström, Elisabeth Sundström, Ulrika Gunnarsson, Bertrand Bed’Hom, Michele Tixier‐Boichard, Christa F. Honaker, Anna‐Stina Sahlqvist, Per Jensen, Olle Kämpe, Paul B. Siegel, Susanne Kerje, Leif Andersson
SummarySex‐linked barring, a common plumage colour found in chickens, is characterized by black and white barred feathers. Previous studies have indicated that the white bands are caused by an absence of melanocytes in the feather follicle during the growth of this region. Here, we show that Sex‐linked barring is controlled by the CDKN2A/B locus, which encodes the INK4b and ARF transcripts. We ide... hiện toàn bộ
Identification of differentially expressed genes in spontaneously regressing melanoma using the MeLiM Swine Model
Pigment Cell and Melanoma Research - Tập 21 Số 2 - Trang 147-161 - 2008
Florian Rambow, Olaf Malek, Claudine Geffrotin, Jean Jacques Leplat, Stéphan Bouet, Guillaume Piton, Karine Hugot, Claudia Bevilacqua, Vratislav Horák, Vincent Coustham
SummaryPartial and some few cases of complete spontaneous regression have been observed in cutaneous melanoma patients but little is known about the molecular mechanisms involved. The Melanoblastoma‐bearing Libechov Minipig (MeLiM) is a suitable animal model to study the phenomenon of spontaneous regression because MeLiM pigs exhibit naturally occurring melanomas which regress completely 6 months ... hiện toàn bộ
Genomic and signalling pathway characterization of the NZM panel of melanoma cell lines: A valuable model for studying the impact of genetic diversity in melanoma
Pigment Cell and Melanoma Research - Tập 34 Số 1 - Trang 136-143 - 2021
Khanh Bao Tran, Grégory Gimenez, Peter Tsai, Sharada Kolekar, Euan J. Rodger, Aniruddha Chatterjee, Anower Jabed, Jen‐Hsing Shih, Wayne R. Joseph, Elaine S. Marshall, Qian Wang, Cristin G. Print, Michael R. Eccles, Bruce C. Baguley, Peter R. Shepherd
AbstractMelanoma is a disease associated with a very high mutation burden and thus the possibility of a diverse range of oncogenic mechanisms that allow it to evade therapeutic interventions and the immune system. Here, we describe the characterization of a panel of 102 cell lines from metastatic melanomas (the NZM lines), including using whole‐exome and RNA sequencing to analyse genetic variants ... hiện toàn bộ
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