Pharmaceutics

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Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment
Pharmaceutics - Tập 13 Số 2 - Trang 152
Eleen Dayana Mohamed Isa, Haslina Ahmad, Mohd Basyaruddin Abdul Rahman, Martin R. Gill
Cancer treatment and therapy have made significant leaps and bounds in these past decades. However, there are still cases where surgical removal is impossible, metastases are challenging, and chemotherapy and radiotherapy pose severe side effects. Therefore, a need to find more effective and specific treatments still exists. One way is through the utilization of drug delivery agents (DDA) ...... hiện toàn bộ
Myeloma Bone Disease: Update on Pathogenesis and Novel Treatment Strategies
Pharmaceutics - Tập 10 Số 4 - Trang 202
Sonia Vallet, Julia-Marie Filzmoser, Martin Pecherstorfer, Klaus Podar
Bone disease, including osteolytic lesions and/or osteoporosis, is a common feature of multiple myeloma (MM). The consequences of skeletal involvement are severe pain, spinal cord compressions, and bone fractures, which have a dramatic impact on patients’ quality of life and, ultimately, survival. During the past few years, several landmark studies significantly enhanced our insight into M...... hiện toàn bộ
A Review of Repurposed Cancer Drugs in Clinical Trials for Potential Treatment of COVID-19
Pharmaceutics - Tập 13 Số 6 - Trang 815
Bárbara Costa, Nuno Vale
The pandemic of the coronavirus disease 2019 (COVID-19) represents an unprecedented challenge to identify effective drugs for prevention and treatment. While the world’s attention is focused on news of COVID-19 vaccine updates, clinical management still requires improvement. Due to the similarity of cancer-induced inflammation, immune dysfunction, and coagulopathy to COVID-19, anticancer d...... hiện toàn bộ
Liposomal Formulations in Clinical Use: An Updated Review
Pharmaceutics - Tập 9 Số 2 - Trang 12
Upendra Bulbake, Sindhu Doppalapudi, Nagavendra Kommineni, Wahid Khan
Liposomes are the first nano drug delivery systems that have been successfully translated into real-time clinical applications. These closed bilayer phospholipid vesicles have witnessed many technical advances in recent years since their first development in 1965. Delivery of therapeutics by liposomes alters their biodistribution profile, which further enhances the therapeutic index of var...... hiện toàn bộ
Anti-PEG IgM Response against PEGylated Liposomes in Mice and Rats
Pharmaceutics - Tập 3 Số 1 - Trang 1-11
Masako Ichihara, Taro Shimizu, Ami Imoto, Yuki Hashiguchi, Yumi Uehara, Tatsuhiro Ishida, Hiroshi Kiwada
We have reported that PEGylated liposomes lose their long-circulating properties when they are administered repeatedly at certain intervals to the same animal. This unexpected phenomenon is referred to as the accelerated blood clearance (ABC) phenomenon. We recently showed that the ABC phenomenon is triggered via the abundant secretion of anti-PEG IgM in response to the first dose of PEGyl...... hiện toàn bộ
Surface-Tailored Zein Nanoparticles: Strategies and Applications
Pharmaceutics - Tập 13 Số 9 - Trang 1354
Ahmed Mohamed Abdelsalam, Ahmed Somaida, Abdallah M. Ayoub, Fahd M. Alsharif, Eduard Preis, Matthias Wojcik, Udo Bakowsky
Plant-derived proteins have emerged as leading candidates in several drug and food delivery applications in diverse pharmaceutical designs. Zein is considered one of the primary plant proteins obtained from maize, and is well known for its biocompatibility and safety in biomedical fields. The ability of zein to carry various pharmaceutically active substances (PAS) position it as a valuabl...... hiện toàn bộ
Zein-Based Nanoparticles as Oral Carriers for Insulin Delivery
Pharmaceutics - Tập 14 Số 1 - Trang 39
Cristian Reboredo, Carlos J. González-Navarro, Ana L. Martínez‐López, Cristina Martínez-Ohárriz, Bruno Sarmento, Juan M. Irache
Zein, the major storage protein from corn, has a GRAS (Generally Regarded as Safe) status and may be easily transformed into nanoparticles, offering significant payloads for protein materials without affecting their stability. In this work, the capability of bare zein nanoparticles (mucoadhesive) and nanoparticles coated with poly(ethylene glycol) (mucus-permeating) was evaluated as oral c...... hiện toàn bộ
Modelling Hydrocortisone Pharmacokinetics on a Subcutaneous Pulsatile Infusion Replacement Strategy in Patients with Adrenocortical Insufficiency
Pharmaceutics - Tập 13 Số 6 - Trang 769
Ioannis G. Violaris, Konstantinos Kalafatakis, Eder Zavala, Ioannis G. Tsoulos, Theodoros Lampros, Stafford L. Lightman, Markos G. Tsipouras, Νικόλαος Γιαννακέας, Alexandros T. Tzallas, Georgina Russell
In the context of glucocorticoid (GC) therapeutics, recent studies have utilised a subcutaneous hydrocortisone (HC) infusion pump programmed to deliver multiple HC pulses throughout the day, with the purpose of restoring normal circadian and ultradian GC rhythmicity. A key challenge for the advancement of novel HC replacement therapies is the calibration of infusion pumps against cortisol ...... hiện toàn bộ
Population Pharmacokinetics and Dose Optimization of Ceftazidime and Imipenem in Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease
Pharmaceutics - Tập 13 Số 4 - Trang 456 - 2021
Nguyen, Thu-Minh, Ngo, Thu-Hue, Truong, Anh-Quan, Vu, Dinh-Hoa, Le, Dinh-Chi, Vu, Ngan-Binh, Can, Tuyet-Nga, Nguyen, Hoang-Anh, Phan, Thu-Phuong, Van Bambeke, Françoise, Vidaillac, Céline, Ngo, Quy-Chau
Background: Ceftazidime and imipenem have been increasingly used to treat Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) due to their extended-spectrum covering Pseudomonas aeruginosa. This study aims to describe the population pharmacokinetic (PK) and pharmacodynamic (PD) target attainment for ceftazidime and imipenem in patients with AECOPD. Methods: We conducted a prospec...... hiện toàn bộ
Liposome Formulation of Fullerene-Based Molecular Diagnostic and Therapeutic Agents
Pharmaceutics - Tập 5 Số 4 - Trang 525-541
Zhiguo Zhou
Fullerene medicine is a new but rapidly growing research subject. Fullerene has a number of desired structural, physical and chemical properties to be adapted for biological use including antioxidants, anti-aging, anti-inflammation, photodynamic therapy, drug delivery, and magnetic resonance imaging contrast agents. Chemical functionalization of fullerenes has led to several interesting co...... hiện toàn bộ
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