Pharmaceutics
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Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment
Pharmaceutics - Tập 13 Số 2 - Trang 152
Cancer treatment and therapy have made significant leaps and bounds in these
past decades. However, there are still cases where surgical removal is
impossible, metastases are challenging, and chemotherapy and radiotherapy pose
severe side effects. Therefore, a need to find more effective and specific
treatments still exists. One way is through the utilization of drug delivery
agents (DDA) based on...
Myeloma Bone Disease: Update on Pathogenesis and Novel Treatment Strategies
Pharmaceutics - Tập 10 Số 4 - Trang 202
Bone disease, including osteolytic lesions and/or osteoporosis, is a common
feature of multiple myeloma (MM). The consequences of skeletal involvement are
severe pain, spinal cord compressions, and bone fractures, which have a dramatic
impact on patients’ quality of life and, ultimately, survival. During the past
few years, several landmark studies significantly enhanced our insight into MM
bone d...
A Review of Repurposed Cancer Drugs in Clinical Trials for Potential Treatment of COVID-19
Pharmaceutics - Tập 13 Số 6 - Trang 815
The pandemic of the coronavirus disease 2019 (COVID-19) represents an
unprecedented challenge to identify effective drugs for prevention and
treatment. While the world’s attention is focused on news of COVID-19 vaccine
updates, clinical management still requires improvement. Due to the similarity
of cancer-induced inflammation, immune dysfunction, and coagulopathy to
COVID-19, anticancer drugs, su...
Liposomal Formulations in Clinical Use: An Updated Review
Pharmaceutics - Tập 9 Số 2 - Trang 12
Liposomes are the first nano drug delivery systems that have been successfully
translated into real-time clinical applications. These closed bilayer
phospholipid vesicles have witnessed many technical advances in recent years
since their first development in 1965. Delivery of therapeutics by liposomes
alters their biodistribution profile, which further enhances the therapeutic
index of various dru...
Anti-PEG IgM Response against PEGylated Liposomes in Mice and Rats
Pharmaceutics - Tập 3 Số 1 - Trang 1-11
We have reported that PEGylated liposomes lose their long-circulating properties
when they are administered repeatedly at certain intervals to the same animal.
This unexpected phenomenon is referred to as the accelerated blood clearance
(ABC) phenomenon. We recently showed that the ABC phenomenon is triggered via
the abundant secretion of anti-PEG IgM in response to the first dose of
PEGylated lip...
Surface-Tailored Zein Nanoparticles: Strategies and Applications
Pharmaceutics - Tập 13 Số 9 - Trang 1354
Plant-derived proteins have emerged as leading candidates in several drug and
food delivery applications in diverse pharmaceutical designs. Zein is considered
one of the primary plant proteins obtained from maize, and is well known for its
biocompatibility and safety in biomedical fields. The ability of zein to carry
various pharmaceutically active substances (PAS) position it as a valuable
conten...
Zein-Based Nanoparticles as Oral Carriers for Insulin Delivery
Pharmaceutics - Tập 14 Số 1 - Trang 39
Zein, the major storage protein from corn, has a GRAS (Generally Regarded as
Safe) status and may be easily transformed into nanoparticles, offering
significant payloads for protein materials without affecting their stability. In
this work, the capability of bare zein nanoparticles (mucoadhesive) and
nanoparticles coated with poly(ethylene glycol) (mucus-permeating) was evaluated
as oral carriers ...
Modelling Hydrocortisone Pharmacokinetics on a Subcutaneous Pulsatile Infusion Replacement Strategy in Patients with Adrenocortical Insufficiency
Pharmaceutics - Tập 13 Số 6 - Trang 769
In the context of glucocorticoid (GC) therapeutics, recent studies have utilised
a subcutaneous hydrocortisone (HC) infusion pump programmed to deliver multiple
HC pulses throughout the day, with the purpose of restoring normal circadian and
ultradian GC rhythmicity. A key challenge for the advancement of novel HC
replacement therapies is the calibration of infusion pumps against cortisol
levels m...
Population Pharmacokinetics and Dose Optimization of Ceftazidime and Imipenem in Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease
Pharmaceutics - Tập 13 Số 4 - Trang 456 - 2021
Background: Ceftazidime and imipenem have been increasingly used to treat Acute
Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) due to their
extended-spectrum covering Pseudomonas aeruginosa. This study aims to describe
the population pharmacokinetic (PK) and pharmacodynamic (PD) target attainment
for ceftazidime and imipenem in patients with AECOPD. Methods: We conducted a
prospec...
Liposome Formulation of Fullerene-Based Molecular Diagnostic and Therapeutic Agents
Pharmaceutics - Tập 5 Số 4 - Trang 525-541
Fullerene medicine is a new but rapidly growing research subject. Fullerene has
a number of desired structural, physical and chemical properties to be adapted
for biological use including antioxidants, anti-aging, anti-inflammation,
photodynamic therapy, drug delivery, and magnetic resonance imaging contrast
agents. Chemical functionalization of fullerenes has led to several interesting
compounds ...
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