Pharmaceutics

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Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment
Pharmaceutics - Tập 13 Số 2 - Trang 152
Eleen Dayana Mohamed Isa, Haslina Ahmad, Mohd Basyaruddin Abdul Rahman, Martin R. Gill
Cancer treatment and therapy have made significant leaps and bounds in these past decades. However, there are still cases where surgical removal is impossible, metastases are challenging, and chemotherapy and radiotherapy pose severe side effects. Therefore, a need to find more effective and specific treatments still exists. One way is through the utilization of drug delivery agents (DDA) ...... hiện toàn bộ
A Review of Repurposed Cancer Drugs in Clinical Trials for Potential Treatment of COVID-19
Pharmaceutics - Tập 13 Số 6 - Trang 815
Bárbara Costa, Nuno Vale
The pandemic of the coronavirus disease 2019 (COVID-19) represents an unprecedented challenge to identify effective drugs for prevention and treatment. While the world’s attention is focused on news of COVID-19 vaccine updates, clinical management still requires improvement. Due to the similarity of cancer-induced inflammation, immune dysfunction, and coagulopathy to COVID-19, anticancer d...... hiện toàn bộ
Zein-Based Nanoparticles as Oral Carriers for Insulin Delivery
Pharmaceutics - Tập 14 Số 1 - Trang 39
Cristian Reboredo, Carlos J. González-Navarro, Ana L. Martínez‐López, Cristina Martínez-Ohárriz, Bruno Sarmento, Juan M. Irache
Zein, the major storage protein from corn, has a GRAS (Generally Regarded as Safe) status and may be easily transformed into nanoparticles, offering significant payloads for protein materials without affecting their stability. In this work, the capability of bare zein nanoparticles (mucoadhesive) and nanoparticles coated with poly(ethylene glycol) (mucus-permeating) was evaluated as oral c...... hiện toàn bộ
Modelling Hydrocortisone Pharmacokinetics on a Subcutaneous Pulsatile Infusion Replacement Strategy in Patients with Adrenocortical Insufficiency
Pharmaceutics - Tập 13 Số 6 - Trang 769
Ioannis G. Violaris, Konstantinos Kalafatakis, Eder Zavala, Ioannis G. Tsoulos, Theodoros Lampros, Stafford L. Lightman, Markos G. Tsipouras, Νικόλαος Γιαννακέας, Alexandros T. Tzallas, Georgina Russell
In the context of glucocorticoid (GC) therapeutics, recent studies have utilised a subcutaneous hydrocortisone (HC) infusion pump programmed to deliver multiple HC pulses throughout the day, with the purpose of restoring normal circadian and ultradian GC rhythmicity. A key challenge for the advancement of novel HC replacement therapies is the calibration of infusion pumps against cortisol ...... hiện toàn bộ
Population Pharmacokinetics and Dose Optimization of Ceftazidime and Imipenem in Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease
Pharmaceutics - Tập 13 Số 4 - Trang 456 - 2021
Nguyen, Thu-Minh, Ngo, Thu-Hue, Truong, Anh-Quan, Vu, Dinh-Hoa, Le, Dinh-Chi, Vu, Ngan-Binh, Can, Tuyet-Nga, Nguyen, Hoang-Anh, Phan, Thu-Phuong, Van Bambeke, Françoise, Vidaillac, Céline, Ngo, Quy-Chau
Background: Ceftazidime and imipenem have been increasingly used to treat Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) due to their extended-spectrum covering Pseudomonas aeruginosa. This study aims to describe the population pharmacokinetic (PK) and pharmacodynamic (PD) target attainment for ceftazidime and imipenem in patients with AECOPD. Methods: We conducted a prospec...... hiện toàn bộ
Liposome Formulation of Fullerene-Based Molecular Diagnostic and Therapeutic Agents
Pharmaceutics - Tập 5 Số 4 - Trang 525-541
Zhiguo Zhou
Fullerene medicine is a new but rapidly growing research subject. Fullerene has a number of desired structural, physical and chemical properties to be adapted for biological use including antioxidants, anti-aging, anti-inflammation, photodynamic therapy, drug delivery, and magnetic resonance imaging contrast agents. Chemical functionalization of fullerenes has led to several interesting co...... hiện toàn bộ
The Physicochemical, Biopharmaceutical, and In Vitro Efficacy Properties of Freeze-Dried Dexamethasone-Loaded Lipomers
Pharmaceutics - Tập 13 Số 8 - Trang 1322
Eloy Pena-Rodríguez, Aida Mata-Ventosa, Laura García‐Vega, Sandra Pérez‐Torras, Francisco Fernández-Campos
Dexamethasone-loaded polymer hybrid nanoparticles were developed as a potential tool to treat alopecia areata due to their follicular targeting ability. Freeze drying (FD) is a common technique used to improve nanoparticle stability; however, there are few studies focused on its effect on ethyl cellulose lipid-core nanoparticles. Nanoparticles were lyophilized with different cryoprotectant...... hiện toàn bộ
Delivery of Insulin via Skin Route for the Management of Diabetes Mellitus: Approaches for Breaching the Obstacles
Pharmaceutics - Tập 13 Số 1 - Trang 100
Abdul Ahad, Mohammad Raish, Yousef A. Bin Jardan, Abdullah M. Al‐Mohizea, Fahad I. Al‐Jenoobi
Insulin is used for the treatment of diabetes mellitus, which is characterized by hyperglycemia. Subcutaneous injections are the standard mode of delivery for insulin therapy; however, this procedure is very often invasive, which hinders patient compliance, particularly for individuals requiring insulin doses four times a day. Furthermore, cases have been reported of sudden hypoglycemia oc...... hiện toàn bộ
Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals
Pharmaceutics - Tập 11 Số 3 - Trang 129
Bahman Homayun, Xueting Lin, Hyo‐Jick Choi
Routes of drug administration and the corresponding physicochemical characteristics of a given route play significant roles in therapeutic efficacy and short term/long term biological effects. Each delivery method has favorable aspects and limitations, each requiring a specific delivery vehicles design. Among various routes, oral delivery has been recognized as the most attractive method, ...... hiện toàn bộ
The Digital Pharmacies Era: How 3D Printing Technology Using Fused Deposition Modeling Can Become a Reality
Pharmaceutics - Tập 11 Số 3 - Trang 128
Maisa R. P. Araújo, Lívia L. Sá‐Barreto, Taís Gratieri, Guilherme M. Gelfuso, Marcílio Cunha‐Filho
The pharmaceutical industry is set to join the fourth industrial revolution with the 3D printing of medicines. The application of 3D printers in compounding pharmacies will turn them into digital pharmacies, wrapping up the telemedicine care cycle and definitively modifying the pharmacotherapeutic treatment of patients. Fused deposition modeling 3D printing technology melts extruded drug-l...... hiện toàn bộ
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