Pharmaceutics

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Liposome Formulation of Fullerene-Based Molecular Diagnostic and Therapeutic Agents
Pharmaceutics - Tập 5 Số 4 - Trang 525-541
Zhiguo Zhou
Fullerene medicine is a new but rapidly growing research subject. Fullerene has a number of desired structural, physical and chemical properties to be adapted for biological use including antioxidants, anti-aging, anti-inflammation, photodynamic therapy, drug delivery, and magnetic resonance imaging contrast agents. Chemical functionalization of fullerenes has led to several interesting co...... hiện toàn bộ
The Physicochemical, Biopharmaceutical, and In Vitro Efficacy Properties of Freeze-Dried Dexamethasone-Loaded Lipomers
Pharmaceutics - Tập 13 Số 8 - Trang 1322
Eloy Pena-Rodríguez, Aida Mata-Ventosa, Laura García‐Vega, Sandra Pérez‐Torras, Francisco Fernández-Campos
Dexamethasone-loaded polymer hybrid nanoparticles were developed as a potential tool to treat alopecia areata due to their follicular targeting ability. Freeze drying (FD) is a common technique used to improve nanoparticle stability; however, there are few studies focused on its effect on ethyl cellulose lipid-core nanoparticles. Nanoparticles were lyophilized with different cryoprotectant...... hiện toàn bộ
Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals
Pharmaceutics - Tập 11 Số 3 - Trang 129
Bahman Homayun, Xueting Lin, Hyo‐Jick Choi
Routes of drug administration and the corresponding physicochemical characteristics of a given route play significant roles in therapeutic efficacy and short term/long term biological effects. Each delivery method has favorable aspects and limitations, each requiring a specific delivery vehicles design. Among various routes, oral delivery has been recognized as the most attractive method, ...... hiện toàn bộ
Customized Novel Design of 3D Printed Pregabalin Tablets for Intra-Gastric Floating and Controlled Release Using Fused Deposition Modeling
Pharmaceutics - Tập 11 Số 11 - Trang 564
Shrawani Lamichhane, Jun-Bom Park, Dong Hwan Sohn, Sang Kil Lee
Three-dimensional (3D) printing has been recently employed in the design and formulation of various dosage forms with the aim of on-demand manufacturing and personalized medicine. In this study, we formulated a floating sustained release system using fused deposition modeling (FDM). Filaments were prepared using hypromellose acetate succinate (HPMCAS), polyethylene glycol (PEG 400) and pre...... hiện toàn bộ
Towards Printed Pediatric Medicines in Hospital Pharmacies: Comparison of 2D and 3D-Printed Orodispersible Warfarin Films with Conventional Oral Powders in Unit Dose Sachets
Pharmaceutics - Tập 11 Số 7 - Trang 334
Heidi Öblom, Erica Sjöholm, Maria Rautamo, Niklas Sandler
To date, the lack of age-appropriate medicines for many indications results in dose manipulation of commercially available dosage forms, commonly resulting in inaccurate doses. Various printing technologies have recently been explored in the pharmaceutical field due to the flexible and precise nature of the techniques. The aim of this study was, therefore, to compare the currently used met...... hiện toàn bộ
An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery
Pharmaceutics - Tập 9 Số 4 - Trang 53
M. Mohammed, Jaweria Syeda, Kishor M. Wasan, Ellen K. Wasan
The focus of this review is to provide an overview of the chitosan based nanoparticles for various non-parenteral applications and also to put a spotlight on current research including sustained release and mucoadhesive chitosan dosage forms. Chitosan is a biodegradable, biocompatible polymer regarded as safe for human dietary use and approved for wound dressing applications. Chitosan has ...... hiện toàn bộ
Peptide-Based Strategies for Targeted Tumor Treatment and Imaging
Pharmaceutics - Tập 13 Số 4 - Trang 481
Abiodun Ayo, Pirjo Laakkonen
Cancer is one of the leading causes of death worldwide. The development of cancer-specific diagnostic agents and anticancer toxins would improve patient survival. The current and standard types of medical care for cancer patients, including surgery, radiotherapy, and chemotherapy, are not able to treat all cancers. A new treatment strategy utilizing tumor targeting peptides to selectively ...... hiện toàn bộ
A Role for Nanoparticles in Treating Traumatic Brain Injury
Pharmaceutics - Tập 11 Số 9 - Trang 473
Badrul Alam Bony, Forrest M. Kievit
Traumatic brain injury (TBI) is one of the main causes of disability in children and young adults, as well as a significant concern for elderly individuals. Depending on the severity, TBI can have a long-term impact on the quality of life for survivors of all ages. The primary brain injury can result in severe disability or fatality, and secondary brain damage can increase the complexities...... hiện toàn bộ
Protein-Based Nanoparticles as Drug Delivery Systems
Pharmaceutics - Tập 12 Số 7 - Trang 604
Seyoung Hong, Dong Wook Choi, Hong Nam Kim, Chun Gwon Park, Wonhwa Lee, Hee Ho Park
Nanoparticles have been extensively used as carriers for the delivery of chemicals and biomolecular drugs, such as anticancer drugs and therapeutic proteins. Natural biomolecules, such as proteins, are an attractive alternative to synthetic polymers commonly used in nanoparticle formulation because of their safety. In general, protein nanoparticles offer many advantages, such as biocompati...... hiện toàn bộ
Natural Diatom Biosilica as Microshuttles in Drug Delivery Systems
Pharmaceutics - Tập 11 Số 10 - Trang 537
Joachim Delasoie, Fabio Zobi
Unicellular diatom microalgae are a promising natural resource of porous biosilica. These microorganisms produce around their membrane a highly porous and extremely structured silica shell called frustule. Once harvested from living algae or from fossil sediments of diatomaceous earth, this biocompatible and non-toxic material offers an exceptional potential in the field of micro/nano-devi...... hiện toàn bộ
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